IL104699A0 - Ester cleavage process for use with beta-lactams - Google Patents

Ester cleavage process for use with beta-lactams

Info

Publication number
IL104699A0
IL104699A0 IL104699A IL10469993A IL104699A0 IL 104699 A0 IL104699 A0 IL 104699A0 IL 104699 A IL104699 A IL 104699A IL 10469993 A IL10469993 A IL 10469993A IL 104699 A0 IL104699 A0 IL 104699A0
Authority
IL
Israel
Prior art keywords
lactams
beta
ester cleavage
cleavage process
ester
Prior art date
Application number
IL104699A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL104699A0 publication Critical patent/IL104699A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/02—Preparation
    • C07D463/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
IL104699A 1992-02-18 1993-02-11 Ester cleavage process for use with beta-lactams IL104699A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/836,640 US5302711A (en) 1992-02-18 1992-02-18 Ester cleavage process for use with β-lactams

Publications (1)

Publication Number Publication Date
IL104699A0 true IL104699A0 (en) 1993-06-10

Family

ID=25272395

Family Applications (1)

Application Number Title Priority Date Filing Date
IL104699A IL104699A0 (en) 1992-02-18 1993-02-11 Ester cleavage process for use with beta-lactams

Country Status (10)

Country Link
US (1) US5302711A (xx)
EP (1) EP0557035A3 (xx)
JP (1) JPH05286971A (xx)
KR (1) KR930017907A (xx)
BR (1) BR9300542A (xx)
CA (1) CA2089540A1 (xx)
HU (1) HUT64351A (xx)
IL (1) IL104699A0 (xx)
MX (1) MX9300761A (xx)
TW (1) TW232694B (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE277930T1 (de) 1999-07-30 2004-10-15 Eisai Co Ltd Verfahren zur herstellung basischer additionssalze eines antibiotikums mit einer anorganischen säure und oxalat-zwischenprodukte
CN103588790A (zh) * 2013-11-29 2014-02-19 中国科学院长春应用化学研究所 7-氨基-3-氯-3-头孢-4-羧酸-对硝基苄基酯的制备方法
CN106866704B (zh) * 2017-02-08 2019-06-14 河北科技大学 催化氢化脱除对硝基苄酯以制备7-acca的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1546757A (en) * 1975-04-10 1979-05-31 Lilly Industries Ltd Crystalline cephalosporin salts
JPS52106891A (en) * 1976-03-03 1977-09-07 Shionogi & Co Ltd Removal of carboxyl protecting group
DE2725519A1 (de) * 1977-06-06 1978-12-21 Shionogi & Co Verfahren zur herstellung freier carbonsaeuren durch esterspaltung
IL72412A (en) * 1983-07-22 1988-05-31 Lilly Co Eli Deesterification of beta-lactam antibiotic esters
EP0263901A1 (en) * 1986-10-08 1988-04-20 The Upjohn Company Conversion of cephalosporin hydrohalide salt to alkali metal salt
WO1987001117A2 (en) * 1985-08-12 1987-02-26 The Upjohn Company Conversion of cephalosporin hydrohalide salt to alkali metal salt
DK0395219T3 (da) * 1989-03-30 1999-02-15 Pfizer Cephalosporiner og deres homologer, fremgangsmåde til deres fremstilling og farmaceutiske præparater
US5043439A (en) * 1990-03-08 1991-08-27 Bristol-Myers Squibb Company Process for production of cephalosporins
US5095107A (en) * 1990-11-05 1992-03-10 Eli Lilly And Company Process for cleavage of esters during the production of cephalosporins

Also Published As

Publication number Publication date
BR9300542A (pt) 1993-08-24
HU9300384D0 (en) 1993-04-28
TW232694B (xx) 1994-10-21
EP0557035A3 (en) 1993-12-01
EP0557035A2 (en) 1993-08-25
CA2089540A1 (en) 1993-08-19
US5302711A (en) 1994-04-12
MX9300761A (es) 1993-09-01
KR930017907A (ko) 1993-09-20
HUT64351A (en) 1993-12-28
JPH05286971A (ja) 1993-11-02

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