JPH052180B2 - - Google Patents

Info

Publication number
JPH052180B2
JPH052180B2 JP60202471A JP20247185A JPH052180B2 JP H052180 B2 JPH052180 B2 JP H052180B2 JP 60202471 A JP60202471 A JP 60202471A JP 20247185 A JP20247185 A JP 20247185A JP H052180 B2 JPH052180 B2 JP H052180B2
Authority
JP
Japan
Prior art keywords
fluorescence intensity
analyte
sample
fractionation
fluorescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP60202471A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6183938A (ja
Inventor
Buritsugusu Jonasan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of JPS6183938A publication Critical patent/JPS6183938A/ja
Publication of JPH052180B2 publication Critical patent/JPH052180B2/ja
Granted legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measurement Of Radiation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)
JP60202471A 1984-09-12 1985-09-11 高度粒子検出能のフラクチユエーシヨン分析法 Granted JPS6183938A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/650,320 US4676640A (en) 1984-09-12 1984-09-12 Fluctuation analysis for enhanced particle detection
US650320 1984-09-12

Publications (2)

Publication Number Publication Date
JPS6183938A JPS6183938A (ja) 1986-04-28
JPH052180B2 true JPH052180B2 (enExample) 1993-01-11

Family

ID=24608399

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60202471A Granted JPS6183938A (ja) 1984-09-12 1985-09-11 高度粒子検出能のフラクチユエーシヨン分析法

Country Status (7)

Country Link
US (1) US4676640A (enExample)
EP (1) EP0175545B1 (enExample)
JP (1) JPS6183938A (enExample)
AT (1) ATE78586T1 (enExample)
AU (1) AU584351B2 (enExample)
CA (1) CA1277505C (enExample)
DE (1) DE3586380T2 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4739171A (en) * 1982-07-12 1988-04-19 Syntex (U.S.A.) Inc. Limited volume method and apparatus for particle counting
US5040889A (en) * 1986-05-30 1991-08-20 Pacific Scientific Company Spectrometer with combined visible and ultraviolet sample illumination
US5013150A (en) * 1988-04-01 1991-05-07 Syntex (U.S.A.) Inc. Method for detection of fluorescence or light scatter
US4934811A (en) * 1988-04-01 1990-06-19 Syntex (U.S.A.) Inc. Apparatus and method for detection of fluorescence or light scatter
US5026159A (en) * 1989-05-19 1991-06-25 Acrogen, Inc. Area-modulated luminescence (AML)
US5304492A (en) * 1991-11-26 1994-04-19 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Spectrophotometer for chemical analyses of fluids
DE4429239A1 (de) * 1994-08-18 1996-02-22 Basf Ag Verfahren zur Fluoreszenz-Korrelations-Spektroskopie und Vorrichtung zu dessen Durchführung
FI98765C (fi) * 1995-01-16 1997-08-11 Erkki Soini Virtaussytometrinen menetelmä ja laite
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US5736330A (en) * 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
EP0852004B1 (en) 1995-10-11 2011-01-19 Luminex Corporation Multiplexed analysis of clinical specimens
AT404513B (de) * 1996-07-12 1998-12-28 Avl Verbrennungskraft Messtech Verfahren und messanordnung zur optischen bestimmung der totalen hämoglobinkonzentration
US6449562B1 (en) 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
JP3447562B2 (ja) * 1998-05-21 2003-09-16 浜松ホトニクス株式会社 解析方法および解析装置
DE10013377A1 (de) * 2000-03-17 2001-09-20 Dade Behring Marburg Gmbh Induzierte Aggregation und Agglutination von Plättchen
AU2001246281A1 (en) * 2000-04-13 2001-10-30 Ecole Polytechnique Federale De Lausanne (Epfl) Assembly and method for a correlator structure
US6534768B1 (en) 2000-10-30 2003-03-18 Euro-Oeltique, S.A. Hemispherical detector
JP4804363B2 (ja) * 2004-02-09 2011-11-02 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 蛍光顕微鏡装置
US7232687B2 (en) * 2004-04-07 2007-06-19 Beckman Coulter, Inc. Multiple sorter monitor and control subsystem for flow cytometer
US20100046902A1 (en) * 2006-11-03 2010-02-25 Trustees Of Tufts College Biopolymer photonic crystals and method of manufacturing the same
US9969134B2 (en) 2006-11-03 2018-05-15 Trustees Of Tufts College Nanopatterned biopolymer optical device and method of manufacturing the same
CA2704304C (en) * 2006-11-03 2015-01-13 Trustees Of Trufts College Biopolymer optical waveguide and method of manufacturing the same
WO2008127402A2 (en) * 2006-11-03 2008-10-23 Trustees Of Tufts College Biopolymer sensor and method of manufacturing the same
WO2009061823A1 (en) 2007-11-05 2009-05-14 Trustees Of Tufts College Fabrication of silk fibroin photonic structures by nanocontact imprinting
JP2011525254A (ja) * 2008-06-18 2011-09-15 トラスティーズ オブ タフツ カレッジ 食用のホログラフィック絹製品
WO2010088585A1 (en) * 2009-01-30 2010-08-05 Trustees Of Boston University Chemical/biological sensor employing scattered chromatic components in nano-patterned aperiodic surfaces
EP2396276B1 (en) 2009-02-12 2016-08-31 Trustees Of Tufts College Nanoimprinting of silk fibroin structures for biomedical and biophotonic applications
EP2419715A1 (en) * 2009-04-15 2012-02-22 Stefan Wennmalm Inverse-fluorescence correlation spectroscopy
JP2012533780A (ja) 2009-07-20 2012-12-27 タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ タンパク質のみからなる移植可能な吸収性反射体
EP2474054A4 (en) 2009-08-31 2013-03-13 Tufts University Trustees Of Tufts College SILK TRANSISTOR DEVICES
JP5442052B2 (ja) * 2012-02-16 2014-03-12 株式会社堀場製作所 粒子分析装置
JP6792235B2 (ja) * 2016-09-05 2020-11-25 株式会社アクロエッジ 凝集体の凝集度の測定方法及び凝集度測定装置

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US99266A (en) * 1870-01-25 Improvement in liquid-meters
US3941479A (en) * 1974-09-26 1976-03-02 G. D. Searle & Co. Use of modulated stimulus to improve detection sensitivity for signals from particles in a flow chamber
US4178917A (en) * 1979-01-03 1979-12-18 Shapiro Howard M Method and system for non-invasive detection of zinc protoporphyrin in erythrocytes
US4421860A (en) * 1980-10-07 1983-12-20 The Regents Of The University Of California Homogeneous fluoroimmunoassay involving autocorrelation processing of optically sensed signals
US4407964A (en) * 1980-10-07 1983-10-04 The Regents Of The University Of California Homogeneous fluoroimmunoassay involving sensing radiation for forward and back directions
US4564598A (en) * 1982-07-12 1986-01-14 Syntex (U.S.A.) Inc. Limited volume method for particle counting
US4537861A (en) * 1983-02-03 1985-08-27 Elings Virgil B Apparatus and method for homogeneous immunoassay
US4560881A (en) * 1984-03-13 1985-12-24 Syntex (U.S.A.) Inc. Method and apparatus for enhanced detection of electromagnetic signals

Also Published As

Publication number Publication date
ATE78586T1 (de) 1992-08-15
DE3586380T2 (de) 1993-03-11
JPS6183938A (ja) 1986-04-28
AU584351B2 (en) 1989-05-25
US4676640A (en) 1987-06-30
DE3586380D1 (de) 1992-08-27
EP0175545A2 (en) 1986-03-26
AU4737485A (en) 1986-03-20
EP0175545A3 (en) 1987-07-29
CA1277505C (en) 1990-12-11
EP0175545B1 (en) 1992-07-22

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