AU4737485A - Fluctuation analysis for enhanced particle detection - Google Patents

Fluctuation analysis for enhanced particle detection

Info

Publication number
AU4737485A
AU4737485A AU47374/85A AU4737485A AU4737485A AU 4737485 A AU4737485 A AU 4737485A AU 47374/85 A AU47374/85 A AU 47374/85A AU 4737485 A AU4737485 A AU 4737485A AU 4737485 A AU4737485 A AU 4737485A
Authority
AU
Australia
Prior art keywords
duration
fluctuations
particle detection
fluctuation analysis
enhanced particle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU47374/85A
Other versions
AU584351B2 (en
Inventor
Jonathan Briggs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of AU4737485A publication Critical patent/AU4737485A/en
Application granted granted Critical
Publication of AU584351B2 publication Critical patent/AU584351B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measurement Of Radiation (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A method for measuring intensity fluctuations of an electromagnetic signal of wavelength between about 350 nm to 1200 nm from a liquid medium autocorrelates the intensity of the signal over a non-zero interval the duration of which is short compared to the mean duration of the fluctuations. Preferably the duration of autocorrelation is between one third and one hundredth of the mean duration of the flucutations. The method has particular applications in the diagnostic area, particularly where such fluctuations are a result of the presence of fluorescent particles in a liquid medium. Methods are also disclosed for determining an analyte in a sample suspected of containing such analyte.
AU47374/85A 1984-09-12 1985-09-11 Fluctuation analysis for enhanced particle detection Ceased AU584351B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/650,320 US4676640A (en) 1984-09-12 1984-09-12 Fluctuation analysis for enhanced particle detection
US650320 1984-09-12

Publications (2)

Publication Number Publication Date
AU4737485A true AU4737485A (en) 1986-03-20
AU584351B2 AU584351B2 (en) 1989-05-25

Family

ID=24608399

Family Applications (1)

Application Number Title Priority Date Filing Date
AU47374/85A Ceased AU584351B2 (en) 1984-09-12 1985-09-11 Fluctuation analysis for enhanced particle detection

Country Status (7)

Country Link
US (1) US4676640A (en)
EP (1) EP0175545B1 (en)
JP (1) JPS6183938A (en)
AT (1) ATE78586T1 (en)
AU (1) AU584351B2 (en)
CA (1) CA1277505C (en)
DE (1) DE3586380T2 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4739171A (en) * 1982-07-12 1988-04-19 Syntex (U.S.A.) Inc. Limited volume method and apparatus for particle counting
US5040889A (en) * 1986-05-30 1991-08-20 Pacific Scientific Company Spectrometer with combined visible and ultraviolet sample illumination
US5013150A (en) * 1988-04-01 1991-05-07 Syntex (U.S.A.) Inc. Method for detection of fluorescence or light scatter
US4934811A (en) * 1988-04-01 1990-06-19 Syntex (U.S.A.) Inc. Apparatus and method for detection of fluorescence or light scatter
US5026159A (en) * 1989-05-19 1991-06-25 Acrogen, Inc. Area-modulated luminescence (AML)
US5304492A (en) * 1991-11-26 1994-04-19 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Spectrophotometer for chemical analyses of fluids
DE4429239A1 (en) * 1994-08-18 1996-02-22 Basf Ag Process for fluorescence correlation spectroscopy and device for carrying it out
FI98765C (en) * 1995-01-16 1997-08-11 Erkki Soini Flow cytometric method and apparatus
CA2227895C (en) 1995-10-11 2012-07-17 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US5736330A (en) * 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
AT404513B (en) * 1996-07-12 1998-12-28 Avl Verbrennungskraft Messtech METHOD AND MEASURING ARRANGEMENT FOR THE OPTICAL DETERMINATION OF TOTAL HEMOGLOBIN CONCENTRATION
US6449562B1 (en) 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
JP3447562B2 (en) * 1998-05-21 2003-09-16 浜松ホトニクス株式会社 Analysis method and analyzer
DE10013377A1 (en) * 2000-03-17 2001-09-20 Dade Behring Marburg Gmbh Measuring aggregation of platelets, useful for diagnosis, e.g. determining aggregation capacity, with measurement taken after vigorous mixing of reactants
JP2003531371A (en) 2000-04-13 2003-10-21 エコール ポリテクニーク フェデラル ドゥ ローザンヌ（エーペーエフエル） Apparatus and method for correlator configuration
US6534768B1 (en) 2000-10-30 2003-03-18 Euro-Oeltique, S.A. Hemispherical detector
CN100526932C (en) * 2004-02-09 2009-08-12 皇家飞利浦电子股份有限公司 Fluorescence microscope arrangement
US7232687B2 (en) * 2004-04-07 2007-06-19 Beckman Coulter, Inc. Multiple sorter monitor and control subsystem for flow cytometer
WO2008118211A2 (en) 2006-11-03 2008-10-02 Trustees Of Tufts College Biopolymer photonic crystals and method of manufacturing the same
WO2008127403A2 (en) 2006-11-03 2008-10-23 Trustees Of Tufts College Biopolymer optofluidic device and method of manufacturing the same
JP2010509645A (en) 2006-11-03 2010-03-25 トラスティーズ オブ タフツ カレッジ Biopolymer optical device having nano pattern formed thereon and method for producing the same
US8529835B2 (en) * 2006-11-03 2013-09-10 Tufts University Biopolymer sensor and method of manufacturing the same
US9599891B2 (en) 2007-11-05 2017-03-21 Trustees Of Tufts College Fabrication of silk fibroin photonic structures by nanocontact imprinting
EP2307054A4 (en) * 2008-06-18 2013-02-06 Tufts College Edible holographic silk products
WO2010088585A1 (en) * 2009-01-30 2010-08-05 Trustees Of Boston University Chemical/biological sensor employing scattered chromatic components in nano-patterned aperiodic surfaces
US8747886B2 (en) 2009-02-12 2014-06-10 Tufts University Nanoimprinting of silk fibroin structures for biomedical and biophotonic applications
EP2419715A1 (en) * 2009-04-15 2012-02-22 Stefan Wennmalm Inverse-fluorescence correlation spectroscopy
AU2010307268B2 (en) 2009-07-20 2015-05-14 Tufts University/Trustees Of Tufts College All-protein implantable, resorbable reflectors
EP2474054A4 (en) 2009-08-31 2013-03-13 Tufts University Trustees Of Tufts College Silk transistor devices
JP5442052B2 (en) * 2012-02-16 2014-03-12 株式会社堀場製作所 Particle analyzer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US99266A (en) * 1870-01-25 Improvement in liquid-meters
US3941479A (en) * 1974-09-26 1976-03-02 G. D. Searle & Co. Use of modulated stimulus to improve detection sensitivity for signals from particles in a flow chamber
US4178917A (en) * 1979-01-03 1979-12-18 Shapiro Howard M Method and system for non-invasive detection of zinc protoporphyrin in erythrocytes
US4421860A (en) * 1980-10-07 1983-12-20 The Regents Of The University Of California Homogeneous fluoroimmunoassay involving autocorrelation processing of optically sensed signals
US4407964A (en) * 1980-10-07 1983-10-04 The Regents Of The University Of California Homogeneous fluoroimmunoassay involving sensing radiation for forward and back directions
US4564598A (en) * 1982-07-12 1986-01-14 Syntex (U.S.A.) Inc. Limited volume method for particle counting
US4537861A (en) * 1983-02-03 1985-08-27 Elings Virgil B Apparatus and method for homogeneous immunoassay
US4560881A (en) * 1984-03-13 1985-12-24 Syntex (U.S.A.) Inc. Method and apparatus for enhanced detection of electromagnetic signals

Also Published As

Publication number Publication date
ATE78586T1 (en) 1992-08-15
DE3586380T2 (en) 1993-03-11
CA1277505C (en) 1990-12-11
DE3586380D1 (en) 1992-08-27
AU584351B2 (en) 1989-05-25
EP0175545A2 (en) 1986-03-26
JPS6183938A (en) 1986-04-28
JPH052180B2 (en) 1993-01-11
EP0175545A3 (en) 1987-07-29
US4676640A (en) 1987-06-30
EP0175545B1 (en) 1992-07-22

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