DE602005011763D1 - Fluoreszenz-mikroskop-anordnung - Google Patents

Fluoreszenz-mikroskop-anordnung

Info

Publication number
DE602005011763D1
DE602005011763D1 DE602005011763T DE602005011763T DE602005011763D1 DE 602005011763 D1 DE602005011763 D1 DE 602005011763D1 DE 602005011763 T DE602005011763 T DE 602005011763T DE 602005011763 T DE602005011763 T DE 602005011763T DE 602005011763 D1 DE602005011763 D1 DE 602005011763D1
Authority
DE
Germany
Prior art keywords
sample
microscope
fluorescence
distribution
focal region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005011763T
Other languages
English (en)
Inventor
Bernhard Gleich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Philips Intellectual Property and Standards GmbH
Original Assignee
Philips Intellectual Property and Standards GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philips Intellectual Property and Standards GmbH filed Critical Philips Intellectual Property and Standards GmbH
Publication of DE602005011763D1 publication Critical patent/DE602005011763D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
DE602005011763T 2004-02-09 2005-01-27 Fluoreszenz-mikroskop-anordnung Active DE602005011763D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04100462 2004-02-09
PCT/IB2005/050354 WO2005076050A1 (en) 2004-02-09 2005-01-27 Fluorescence microscope arrangement

Publications (1)

Publication Number Publication Date
DE602005011763D1 true DE602005011763D1 (de) 2009-01-29

Family

ID=34833743

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005011763T Active DE602005011763D1 (de) 2004-02-09 2005-01-27 Fluoreszenz-mikroskop-anordnung

Country Status (7)

Country Link
US (1) US20070161075A1 (de)
EP (1) EP1716444B1 (de)
JP (1) JP4804363B2 (de)
CN (1) CN100526932C (de)
AT (1) ATE418084T1 (de)
DE (1) DE602005011763D1 (de)
WO (1) WO2005076050A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5010914B2 (ja) * 2003-04-15 2012-08-29 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 磁性粒子の空間分布を決める方法及び磁性粒子を投与する組成物
DE102005017817A1 (de) * 2005-04-18 2006-10-26 Siemens Ag Verfahren und Vorrichtung zur Untersuchung eines biologischen Gewebes
JP2009502402A (ja) * 2005-08-01 2009-01-29 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 光学イメージング
JP2011022201A (ja) * 2009-07-13 2011-02-03 Jikei Univ 顕微鏡装置用の光源装置、及び光源装置付き観察試料載置具、並びに顕微鏡装置
CN103575716A (zh) * 2013-11-15 2014-02-12 中国科学院长春应用化学研究所 磁场调控的超分辨荧光成像方法
EP3859425B1 (de) 2015-09-17 2024-04-17 S.D. Sight Diagnostics Ltd. Verfahren und vorrichtung zur detektion einer entität in einer körperprobe
CA3018536A1 (en) 2016-03-30 2017-10-05 S.D. Sight Diagnostics Ltd Distinguishing between blood sample components
US11307196B2 (en) 2016-05-11 2022-04-19 S.D. Sight Diagnostics Ltd. Sample carrier for optical measurements
US11921272B2 (en) 2017-11-14 2024-03-05 S.D. Sight Diagnostics Ltd. Sample carrier for optical measurements
DE102018206406B3 (de) * 2018-04-25 2019-09-12 Carl Zeiss Meditec Ag Mikroskopiesystem und Verfahren zum Betrieb eines Mikroskopiesystems

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4578167A (en) * 1982-09-28 1986-03-25 Biofusion, Inc. Cell fusion
US4676640A (en) * 1984-09-12 1987-06-30 Syntex (U.S.A.) Inc. Fluctuation analysis for enhanced particle detection
DE19508366C2 (de) * 1995-03-10 1998-01-29 Evotec Biosystems Gmbh Verfahren zum direkten Nachweisen weniger Nucleinsäurestränge
MY139225A (en) * 1998-02-26 2009-08-28 Anglo Operations Ltd Method and apparatus for separating particles
DE19903001A1 (de) * 1999-01-26 2000-08-24 Evotec Biosystems Ag Verfahren und Vorrichtung zur Detektion mikroskopisch kleiner Objekte
US6271660B1 (en) * 1999-06-11 2001-08-07 Mts Sytems Corporation Permanent multi-pole position magnet
US6437551B1 (en) * 1999-11-02 2002-08-20 The Regents Of The University Of California Microfabricated AC impedance sensor
JP4994560B2 (ja) * 2000-08-25 2012-08-08 アムニス コーポレイション 細胞などの小さな移動物体の速度測定
DE10103304A1 (de) * 2001-01-25 2002-08-01 Gnothis Holding Sa Ecublens Verfahren zur fluoreszenzspektroskopischen, insbesondere fluoreszenzkorrelationsspektroskopischen Untersuchung einer Messprobe sowie Einrichtung zur Durchführung desselben
US20020127144A1 (en) * 2001-03-08 2002-09-12 Mehta Shailesh P. Device for analyzing particles and method of use
US7968305B2 (en) * 2001-03-24 2011-06-28 Aviva Biosciences Corporation Biochips including ion transport detecting structures and methods of use
DE10151778A1 (de) * 2001-10-19 2003-05-08 Philips Corp Intellectual Pty Verfahren zur Ermittlung der räumlichen Verteilung magnetischer Partikel
ATE543428T1 (de) * 2003-04-15 2012-02-15 Koninkl Philips Electronics Nv Anordnung sowie verfahren zur räumlich aufgelösten bestimmung von zustandsgrössen in einem untersuchungsbereich

Also Published As

Publication number Publication date
EP1716444B1 (de) 2008-12-17
EP1716444A1 (de) 2006-11-02
JP2007522502A (ja) 2007-08-09
JP4804363B2 (ja) 2011-11-02
CN1918501A (zh) 2007-02-21
US20070161075A1 (en) 2007-07-12
WO2005076050A1 (en) 2005-08-18
CN100526932C (zh) 2009-08-12
ATE418084T1 (de) 2009-01-15

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