JPH051794B2 - - Google Patents

Info

Publication number
JPH051794B2
JPH051794B2 JP60295172A JP29517285A JPH051794B2 JP H051794 B2 JPH051794 B2 JP H051794B2 JP 60295172 A JP60295172 A JP 60295172A JP 29517285 A JP29517285 A JP 29517285A JP H051794 B2 JPH051794 B2 JP H051794B2
Authority
JP
Japan
Prior art keywords
compound
nmr
melting point
yellow powder
pale yellow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP60295172A
Other languages
English (en)
Japanese (ja)
Other versions
JPS62155284A (ja
Inventor
Tadashi Hirata
Mitsuru Takahashi
Tsutomu Muragata
Hiroshi Kase
Koji Yamada
Kazuyuki Iwahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP29517285A priority Critical patent/JPS62155284A/ja
Publication of JPS62155284A publication Critical patent/JPS62155284A/ja
Publication of JPH051794B2 publication Critical patent/JPH051794B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP29517285A 1985-12-27 1985-12-27 生理活性物質ｋ−２５２の誘導体 Granted JPS62155284A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP29517285A JPS62155284A (ja) 1985-12-27 1985-12-27 生理活性物質ｋ−２５２の誘導体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP29517285A JPS62155284A (ja) 1985-12-27 1985-12-27 生理活性物質ｋ−２５２の誘導体

Publications (2)

Publication Number Publication Date
JPS62155284A JPS62155284A (ja) 1987-07-10
JPH051794B2 true JPH051794B2 (enrdf_load_stackoverflow) 1993-01-11

Family

ID=17817161

Family Applications (1)

Application Number Title Priority Date Filing Date
JP29517285A Granted JPS62155284A (ja) 1985-12-27 1985-12-27 生理活性物質ｋ−２５２の誘導体

Country Status (1)

Country Link
JP (1) JPS62155284A (enrdf_load_stackoverflow)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007045A1 (en) * 1987-03-09 1988-09-22 Kyowa Hakko Kogyo Co., Ltd. Derivatives of physiologically active substance k-252
JPH07113027B2 (ja) * 1987-12-24 1995-12-06 協和醗酵工業株式会社 Ｋ−２５２誘導体
US6271242B1 (en) 1992-02-10 2001-08-07 Bristol-Myers Squibb Co. Method for treating cancer using a tyrosine protein kinase inhibitor
US5621101A (en) * 1992-07-24 1997-04-15 Cephalon, Inc. Protein kinase inhibitors for treatment of neurological disorders
US5461146A (en) * 1992-07-24 1995-10-24 Cephalon, Inc. Selected protein kinase inhibitors for the treatment of neurological disorders
US5756494A (en) * 1992-07-24 1998-05-26 Cephalon, Inc. Protein kinase inhibitors for treatment of neurological disorders
JPH08500112A (ja) * 1992-08-12 1996-01-09 ジ・アップジョン・カンパニー タキソールと組み合わせるプロテインキナーゼ阻害剤および関連化合物
WO1994006799A1 (fr) * 1992-09-21 1994-03-31 Kyowa Hakko Kogyo Co., Ltd. Remede contre la thrombopenie
ES2355184T3 (es) 1993-01-28 2011-03-23 Boston Scientific Limited Inhibidores terapéuticos de células de músculo liso vascular.
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
EP0839814A3 (en) * 1993-05-28 1998-09-16 Cephalon, Inc. Indolocarbazole derivatives and their use for the treatment of prostate gland disorders
WO1995022331A1 (en) * 1994-02-18 1995-08-24 Cephalon, Inc. Aqueous indolocarbazole solutions
ATE200290T1 (de) * 1994-07-04 2001-04-15 Kyowa Hakko Kogyo Kk Verfahren zur herstellung von indolocarbazol- derivaten
AU6714396A (en) * 1995-07-28 1997-02-26 Trustees Of Boston University Methods and compositions for treating cell proliferative disorders
US6875865B1 (en) 1996-06-03 2005-04-05 Cephalon, Inc. Selected derivatives of K-252a
UA67725C2 (en) 1996-06-03 2004-07-15 Cephalon Inc K-252a derivatives and a method for improvement of functioning and cell survival enhancement
EP0912184B1 (en) 1996-06-25 2002-09-25 Cephalon, Inc. Use of k-252a derivative for the treatment of peripheral or central nerve disorders, and cytokine overproduction
ES2226120T3 (es) 1997-03-31 2005-03-16 Boston Scientific Limited Inhibidor terapeutico de celulas del musculo liso vascular.
CA2315953C (en) 1997-12-31 2010-11-09 Cephalon, Inc. 3'-epimeric k-252a derivatives
US7795246B2 (en) 1998-08-06 2010-09-14 Cephalon, Inc. Particle-forming compositions containing fused pyrrolocarbazoles
US6200968B1 (en) 1998-08-06 2001-03-13 Cephalon, Inc. Particle-forming compositions containing fused pyrrolocarbazoles
US6472385B1 (en) 1999-08-09 2002-10-29 Trustees Of Darmouth College Compositions and methods to enhance cancer chemotherapy in p53 defective tumors
MX2007001155A (es) * 2004-07-29 2007-08-14 Creabilis Therapeutics Spa Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6041489A (ja) * 1983-08-12 1985-03-05 Kyowa Hakko Kogyo Co Ltd 新規生理活性物質ｋ―２５２

Also Published As

Publication number Publication date
JPS62155284A (ja) 1987-07-10

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Legal Events

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EXPY Cancellation because of completion of term