JPH0469608B2 - - Google Patents
Info
- Publication number
- JPH0469608B2 JPH0469608B2 JP59242450A JP24245084A JPH0469608B2 JP H0469608 B2 JPH0469608 B2 JP H0469608B2 JP 59242450 A JP59242450 A JP 59242450A JP 24245084 A JP24245084 A JP 24245084A JP H0469608 B2 JPH0469608 B2 JP H0469608B2
- Authority
- JP
- Japan
- Prior art keywords
- extract
- powder
- sample
- herbal medicine
- extraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000284 extract Substances 0.000 claims description 137
- 239000000843 powder Substances 0.000 claims description 82
- 238000000605 extraction Methods 0.000 claims description 59
- 241000411851 herbal medicine Species 0.000 claims description 59
- 229920001353 Dextrin Polymers 0.000 claims description 22
- 239000004375 Dextrin Substances 0.000 claims description 22
- 235000019425 dextrin Nutrition 0.000 claims description 22
- 238000002156 mixing Methods 0.000 claims description 21
- 229920002472 Starch Polymers 0.000 claims description 19
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 19
- 235000019698 starch Nutrition 0.000 claims description 19
- 239000002904 solvent Substances 0.000 claims description 13
- 238000001035 drying Methods 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 8
- 239000012141 concentrate Substances 0.000 claims description 7
- 229920000084 Gum arabic Polymers 0.000 claims description 6
- 239000000205 acacia gum Substances 0.000 claims description 6
- 235000010489 acacia gum Nutrition 0.000 claims description 6
- 229920002678 cellulose Polymers 0.000 claims description 6
- 235000010980 cellulose Nutrition 0.000 claims description 6
- 241000416162 Astragalus gummifer Species 0.000 claims description 4
- 229920001615 Tragacanth Polymers 0.000 claims description 4
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical class O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims description 3
- 235000000346 sugar Nutrition 0.000 claims description 2
- 241000978776 Senegalia senegal Species 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 239000008187 granular material Substances 0.000 description 44
- 238000010438 heat treatment Methods 0.000 description 29
- 239000007788 liquid Substances 0.000 description 24
- 238000012360 testing method Methods 0.000 description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 22
- 238000000034 method Methods 0.000 description 21
- 239000009927 gorei-san Substances 0.000 description 20
- 239000000203 mixture Substances 0.000 description 17
- 239000008107 starch Substances 0.000 description 17
- 239000009506 keishibukuryogan Substances 0.000 description 15
- 238000000926 separation method Methods 0.000 description 14
- 239000000126 substance Substances 0.000 description 14
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 13
- 238000004458 analytical method Methods 0.000 description 13
- 239000008101 lactose Substances 0.000 description 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 12
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 11
- 229930195725 Mannitol Natural products 0.000 description 11
- 239000000594 mannitol Substances 0.000 description 11
- 235000010355 mannitol Nutrition 0.000 description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 10
- 238000004128 high performance liquid chromatography Methods 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 238000007906 compression Methods 0.000 description 8
- 230000006835 compression Effects 0.000 description 8
- -1 Keishikazutsuketo Substances 0.000 description 7
- 238000001694 spray drying Methods 0.000 description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- 244000215068 Acacia senegal Species 0.000 description 5
- 229920000858 Cyclodextrin Polymers 0.000 description 5
- 229930006000 Sucrose Natural products 0.000 description 5
- 239000001913 cellulose Substances 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 230000007774 longterm Effects 0.000 description 5
- 239000011259 mixed solution Substances 0.000 description 5
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 5
- 239000005720 sucrose Substances 0.000 description 5
- 229920002261 Corn starch Polymers 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 238000007664 blowing Methods 0.000 description 4
- 239000008120 corn starch Substances 0.000 description 4
- 229940099112 cornstarch Drugs 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 238000004821 distillation Methods 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 239000009569 juzentaihoto Substances 0.000 description 4
- 238000012856 packing Methods 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 159000000007 calcium salts Chemical class 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 238000012733 comparative method Methods 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
- 230000008014 freezing Effects 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 238000001291 vacuum drying Methods 0.000 description 3
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 2
- 244000303040 Glycyrrhiza glabra Species 0.000 description 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 2
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 2
- 229940084030 carboxymethylcellulose calcium Drugs 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000007908 dry granulation Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 229940010454 licorice Drugs 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 108010021724 tonin Proteins 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- 244000307888 Acanthus ebracteatus Species 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 241001365752 Castanopsis sclerophylla Species 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 235000002767 Daucus carota Nutrition 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 239000009566 Mao-to Substances 0.000 description 1
- 244000184734 Pyrus japonica Species 0.000 description 1
- 241001125046 Sardina pilchardus Species 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 239000010175 Yi-Gan San Substances 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 239000009520 bofu-tsusho-san Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000000326 densiometry Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000009896 gosha-jinki-gan Substances 0.000 description 1
- 239000010358 hachimijiogan Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000009428 kamisyoyo san Substances 0.000 description 1
- 239000009382 keishi-to Substances 0.000 description 1
- 239000008863 koso-san Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000008535 sairei-to Substances 0.000 description 1
- 235000019512 sardine Nutrition 0.000 description 1
- 239000010243 sho-seiryu-to Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 239000008704 toki-shakuyaku-san Substances 0.000 description 1
- 238000009777 vacuum freeze-drying Methods 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59242450A JPS61122217A (ja) | 1984-11-19 | 1984-11-19 | 漢方薬エキス剤の製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59242450A JPS61122217A (ja) | 1984-11-19 | 1984-11-19 | 漢方薬エキス剤の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61122217A JPS61122217A (ja) | 1986-06-10 |
| JPH0469608B2 true JPH0469608B2 (pl) | 1992-11-06 |
Family
ID=17089274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59242450A Granted JPS61122217A (ja) | 1984-11-19 | 1984-11-19 | 漢方薬エキス剤の製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61122217A (pl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63246319A (ja) * | 1987-04-01 | 1988-10-13 | Kao Corp | 入浴剤 |
| ATE419829T1 (de) * | 1999-08-27 | 2009-01-15 | Cj Cheiljedang Corp | Extrakte aus pueraria mirifica sowie deren extraktion |
| JP5083492B2 (ja) * | 2006-03-13 | 2012-11-28 | ライオン株式会社 | 内服用液剤 |
| CN103142705B (zh) * | 2012-09-20 | 2014-10-08 | 北京市畜牧兽医总站 | 一种初生仔猪体表干燥消毒粉剂及其制备方法 |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5082262A (pl) * | 1973-11-26 | 1975-07-03 | ||
| JPS5083454A (pl) * | 1973-11-26 | 1975-07-05 | ||
| JPS5221573A (en) * | 1975-08-08 | 1977-02-18 | Dba Sa | Disc brake |
| JPS52128270A (en) * | 1976-04-19 | 1977-10-27 | Iwata Kagaku Kogyo | Production of food having good holding property of vegetable oil |
| JPS56158060A (en) * | 1979-10-25 | 1981-12-05 | Procter & Gamble | Collection of aromatic and taste volatile substance on food substrate |
| JPS56164768A (en) * | 1980-05-24 | 1981-12-17 | Ajinomoto Co Inc | Separation and collection of scent component of dried fish |
| JPS5724306A (en) * | 1980-07-16 | 1982-02-08 | Wakunaga Yakuhin Kk | Preparation of solid chinese herbal pharmaceutical |
| JPS58192826A (ja) * | 1982-05-06 | 1983-11-10 | Yaizu Suisan Kagaku Kogyo Kk | 漢方製剤の製造方法 |
-
1984
- 1984-11-19 JP JP59242450A patent/JPS61122217A/ja active Granted
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5082262A (pl) * | 1973-11-26 | 1975-07-03 | ||
| JPS5083454A (pl) * | 1973-11-26 | 1975-07-05 | ||
| JPS5221573A (en) * | 1975-08-08 | 1977-02-18 | Dba Sa | Disc brake |
| JPS52128270A (en) * | 1976-04-19 | 1977-10-27 | Iwata Kagaku Kogyo | Production of food having good holding property of vegetable oil |
| JPS56158060A (en) * | 1979-10-25 | 1981-12-05 | Procter & Gamble | Collection of aromatic and taste volatile substance on food substrate |
| JPS56164768A (en) * | 1980-05-24 | 1981-12-17 | Ajinomoto Co Inc | Separation and collection of scent component of dried fish |
| JPS5724306A (en) * | 1980-07-16 | 1982-02-08 | Wakunaga Yakuhin Kk | Preparation of solid chinese herbal pharmaceutical |
| JPS58192826A (ja) * | 1982-05-06 | 1983-11-10 | Yaizu Suisan Kagaku Kogyo Kk | 漢方製剤の製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61122217A (ja) | 1986-06-10 |
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