JPH0466450B2 - - Google Patents
Info
- Publication number
- JPH0466450B2 JPH0466450B2 JP60169395A JP16939585A JPH0466450B2 JP H0466450 B2 JPH0466450 B2 JP H0466450B2 JP 60169395 A JP60169395 A JP 60169395A JP 16939585 A JP16939585 A JP 16939585A JP H0466450 B2 JPH0466450 B2 JP H0466450B2
- Authority
- JP
- Japan
- Prior art keywords
- enteric
- coating
- capsule
- capsules
- coated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000011248 coating agent Substances 0.000 claims description 27
- 238000000576 coating method Methods 0.000 claims description 25
- 239000003814 drug Substances 0.000 claims description 20
- 229940079593 drug Drugs 0.000 claims description 18
- 239000007902 hard capsule Substances 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 9
- 239000007888 film coating Substances 0.000 claims description 8
- 238000009501 film coating Methods 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 4
- 230000001079 digestive effect Effects 0.000 claims description 2
- 239000002775 capsule Substances 0.000 description 53
- 238000009505 enteric coating Methods 0.000 description 26
- 239000002702 enteric coating Substances 0.000 description 26
- 239000007788 liquid Substances 0.000 description 18
- 238000005507 spraying Methods 0.000 description 11
- 238000004519 manufacturing process Methods 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 8
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 7
- 239000002253 acid Substances 0.000 description 7
- 239000008101 lactose Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 239000003826 tablet Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 229920002261 Corn starch Polymers 0.000 description 4
- -1 carboxymethyl ethyl Chemical group 0.000 description 4
- 239000007931 coated granule Substances 0.000 description 4
- 239000008120 corn starch Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 239000000454 talc Substances 0.000 description 4
- 229910052623 talc Inorganic materials 0.000 description 4
- 102000001399 Kallikrein Human genes 0.000 description 3
- 108060005987 Kallikrein Proteins 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 210000004051 gastric juice Anatomy 0.000 description 3
- 238000012812 general test Methods 0.000 description 3
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 3
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 229940075894 denatured ethanol Drugs 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 102000038379 digestive enzymes Human genes 0.000 description 2
- 108091007734 digestive enzymes Proteins 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 210000001156 gastric mucosa Anatomy 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 229960003709 kallidinogenase Drugs 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 2
- 239000012046 mixed solvent Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 108010004032 Bromelains Proteins 0.000 description 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- 102000016387 Pancreatic elastase Human genes 0.000 description 1
- 108010067372 Pancreatic elastase Proteins 0.000 description 1
- 108010019160 Pancreatin Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 235000019835 bromelain Nutrition 0.000 description 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000011247 coating layer Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000003405 delayed action preparation Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 229940079919 digestives enzyme preparation Drugs 0.000 description 1
- 239000002662 enteric coated tablet Substances 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- POOYFSLWYLDQMD-UHFFFAOYSA-N heptacalcium;zinc Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Zn+2] POOYFSLWYLDQMD-UHFFFAOYSA-N 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 125000005395 methacrylic acid group Chemical group 0.000 description 1
- 229940055695 pancreatin Drugs 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 230000013777 protein digestion Effects 0.000 description 1
- 229950000112 serrapeptase Drugs 0.000 description 1
- 108010038132 serratiopeptidase Proteins 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 238000001771 vacuum deposition Methods 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60169395A JPS6229515A (ja) | 1985-07-30 | 1985-07-30 | 硬カプセル剤のフイルムコ−テイング方法 |
| DE8686101918T DE3677425D1 (de) | 1985-07-30 | 1986-02-14 | Verfahren zum filmdragieren von hartkapseln. |
| EP86101918A EP0210325B1 (en) | 1985-07-30 | 1986-02-14 | Method of film-coating hard capsules |
| US06/829,267 US4670287A (en) | 1985-07-30 | 1986-02-14 | Method of film-coating hard capsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60169395A JPS6229515A (ja) | 1985-07-30 | 1985-07-30 | 硬カプセル剤のフイルムコ−テイング方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6229515A JPS6229515A (ja) | 1987-02-07 |
| JPH0466450B2 true JPH0466450B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1992-10-23 |
Family
ID=15885802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60169395A Granted JPS6229515A (ja) | 1985-07-30 | 1985-07-30 | 硬カプセル剤のフイルムコ−テイング方法 |
Country Status (4)
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5194464A (en) * | 1988-09-27 | 1993-03-16 | Takeda Chemical Industries, Ltd. | Enteric film and preparatoin thereof |
| US4965089A (en) * | 1989-04-10 | 1990-10-23 | Sauter Manufacturing Corp. | Method and apparatus for the gelatin coating of caplets |
| US6482516B1 (en) * | 1993-07-20 | 2002-11-19 | Banner Pharmacaps, Inc. | Enrobed tablet |
| US5146730A (en) * | 1989-09-20 | 1992-09-15 | Banner Gelatin Products Corp. | Film-enrobed unitary-core medicament and the like |
| JPH0647530B2 (ja) * | 1990-02-03 | 1994-06-22 | ユニコロイド株式会社 | 腸疾患用薬剤カプセル及びその製法 |
| JPH064531B2 (ja) * | 1990-06-04 | 1994-01-19 | アイセロ化学株式会社 | 大腸崩壊性硬質カプセル |
| US5146758A (en) * | 1991-03-04 | 1992-09-15 | Herman Norman L | Process of producing soft elastic gelatin capsules |
| US5366756A (en) * | 1992-06-15 | 1994-11-22 | United States Surgical Corporation | Method for treating bioabsorbable implant material |
| TW550090B (en) * | 1997-05-09 | 2003-09-01 | Sage Pharmaceuticals Inc | Stable oral pharmaceutical dosage forms for acid-unstable drug |
| US6274591B1 (en) | 1997-11-03 | 2001-08-14 | Joseph F. Foss | Use of methylnaltrexone and related compounds |
| US6559158B1 (en) | 1997-11-03 | 2003-05-06 | Ur Labs, Inc. | Use of methylnaltrexone and related compounds to treat chronic opioid use side affects |
| US20030158220A1 (en) * | 1997-11-03 | 2003-08-21 | Foss Joseph F. | Use of methylnaltrexone and related compounds to treat chronic opioid use side effects |
| US7094426B2 (en) * | 1998-08-27 | 2006-08-22 | Sage Pharmaceuticals, Inc. | Stable oral pharmaceutical dosage forms |
| US6669954B2 (en) | 2000-01-25 | 2003-12-30 | John R. Crison | Controlled release of drugs |
| US8263112B2 (en) * | 2000-11-20 | 2012-09-11 | Sorbent Therapeutics, Inc. | In vivo use of water absorbent polymers |
| EP1404323B1 (en) * | 2001-06-05 | 2009-10-28 | The University of Chicago | Use of methylnaltrexone to treat immune suppression |
| CA2521369A1 (en) * | 2003-04-08 | 2004-10-28 | Progenics Pharmaceuticals, Inc. | The use of peripheral opiois antagonists, especially methylnaltrexone to treat irritable bowel syndrome |
| CA2521379C (en) | 2003-04-08 | 2013-07-02 | Progenics Pharmaceuticals, Inc. | Pharmaceutical formulations containing methylnaltrexone |
| RU2005134364A (ru) * | 2003-04-08 | 2006-06-10 | Проджиникс Фармасьютикалз, Инк. (Us) | Комбинированное лечение запора |
| US20050152969A1 (en) * | 2004-01-08 | 2005-07-14 | Chiprich Timothy B. | Colored liquid-filled soft capsules and method of manufacture thereof |
| US20060205753A1 (en) * | 2005-01-20 | 2006-09-14 | Israel Robert J | Use of methylnaltrexone and related compounds to treat post-operative gastrointestinal dysfunction |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| MX2007010833A (es) * | 2005-03-07 | 2009-02-17 | Univ Chicago | Uso de antagonistas opioides para atenuar proliferacion y migracion de células endoteliales. |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| CA2604595A1 (en) * | 2005-04-04 | 2006-10-12 | Archer-Daniels-Midland Company | Lignan-containing compositions |
| AR057035A1 (es) * | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
| AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
| US20080194611A1 (en) * | 2005-06-03 | 2008-08-14 | Alverdy John C | Modulation of Cell Barrier Dysfunction |
| US8784886B2 (en) * | 2006-03-09 | 2014-07-22 | GlaxoSmithKline, LLC | Coating capsules with active pharmaceutical ingredients |
| EP2081550B2 (en) | 2006-03-09 | 2021-05-26 | Reliant Pharmaceuticals, Inc. | Coating capsules with active pharmaceutical ingredients |
| TWI489984B (zh) | 2006-08-04 | 2015-07-01 | Wyeth Corp | 用於非經腸道傳輸化合物之配方及其用途 |
| TW200817048A (en) * | 2006-09-08 | 2008-04-16 | Wyeth Corp | Dry powder compound formulations and uses thereof |
| DK2565195T3 (en) | 2007-03-29 | 2015-06-29 | Wyeth Llc | PERIPHERAL OPIOID RECEPTOR AND ANTAGONISTS AND USES THEREOF |
| AU2008233129B2 (en) | 2007-03-29 | 2014-03-20 | Progenics Pharmaceuticals, Inc. | Peripheral opioid receptor antagonists and uses thereof |
| MX2009010550A (es) | 2007-03-29 | 2009-12-14 | Progenics Pharm Inc | Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas. |
| JP5358587B2 (ja) | 2008-02-06 | 2013-12-04 | プロジェニックス・ファーマシューティカルス・インコーポレイテッド | （ｒ），（ｒ）−２，２’−ビス−メチルナルトレキソンの製造及び用途 |
| JP5647098B2 (ja) | 2008-03-21 | 2014-12-24 | ザ ユニヴァーシティー オヴ シカゴ | オピオイド拮抗薬とｍＴＯＲ阻害薬を用いた治療 |
| US20110250278A1 (en) | 2008-07-01 | 2011-10-13 | University Of Chicago | Particles containing an opioid receptor antagonist and methods of use |
| CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
| WO2011037618A2 (en) * | 2009-09-23 | 2011-03-31 | Todd Ehrlich | Dietary supplements in beverages or other forms, and methods of use and production |
| WO2011063394A2 (en) * | 2009-11-23 | 2011-05-26 | Olmstead Stephen F | Compositions and methods comprising serratia peptidase for inhibition and treatment of biofilms related to certain conditions |
| EP2946773A1 (en) | 2014-05-19 | 2015-11-25 | Tillotts Pharma AG | Modified release coated capsules |
| ES2793530T3 (es) | 2014-05-19 | 2020-11-16 | Tillotts Pharma Ag | Cápsulas revestidas de liberación modificada |
| JP6686013B2 (ja) | 2014-10-17 | 2020-04-22 | サリックス ファーマスーティカルズ，インコーポレーテッド | 腫瘍の進行を減弱させるためのメチルナルトレキソンの使用 |
| EP3025709B1 (en) * | 2014-11-27 | 2020-09-30 | Capsugel Belgium NV | Dosage form articles for external mucosal applications |
| CN104922088A (zh) * | 2015-06-09 | 2015-09-23 | 绍兴康可胶囊有限公司 | 一种硬空心胶囊封口胶的配方 |
| CN104940161A (zh) * | 2015-06-10 | 2015-09-30 | 绍兴康可胶囊有限公司 | 一种硬空心胶囊封口胶的制备方法 |
| FR3070010B1 (fr) * | 2017-08-02 | 2020-12-25 | Belles Feuilles | Procede et systeme pour conditionner une composition d'extraits secs de plantes, et composition d'extraits secs de plantes ainsi mis en oeuvre. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2137170A1 (en) * | 1971-05-14 | 1972-12-29 | Festa Blaise | Coating process with gastric juice-resistant soln - - for gelatine capsules |
| US3900583A (en) * | 1971-08-10 | 1975-08-19 | American Home Prod | Contoured belt coating method |
| DE2319960C2 (de) * | 1973-04-19 | 1974-11-21 | Bruno Dr. 3052 Bad Nenndorf Stellmach | Verfahren und Vorrichtung zum Dragieren von Tabletten |
| JPS53133625A (en) * | 1977-04-25 | 1978-11-21 | Shin Etsu Chem Co Ltd | Manufacturing of pharmaceutical coated with enteric film |
-
1985
- 1985-07-30 JP JP60169395A patent/JPS6229515A/ja active Granted
-
1986
- 1986-02-14 DE DE8686101918T patent/DE3677425D1/de not_active Expired - Lifetime
- 1986-02-14 EP EP86101918A patent/EP0210325B1/en not_active Expired
- 1986-02-14 US US06/829,267 patent/US4670287A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US4670287A (en) | 1987-06-02 |
| DE3677425D1 (de) | 1991-03-14 |
| EP0210325B1 (en) | 1991-02-06 |
| EP0210325A2 (en) | 1987-02-04 |
| JPS6229515A (ja) | 1987-02-07 |
| EP0210325A3 (en) | 1987-10-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |