JPH0458450B2 - - Google Patents

Info

Publication number

JPH0458450B2

JPH0458450B2 JP59033152A JP3315284A JPH0458450B2 JP H0458450 B2 JPH0458450 B2 JP H0458450B2 JP 59033152 A JP59033152 A JP 59033152A JP 3315284 A JP3315284 A JP 3315284A JP H0458450 B2 JPH0458450 B2 JP H0458450B2

Authority

JP

Japan

Prior art keywords

yokuinin

extract

fraction

warts

water

Prior art date

1984-02-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Lifetime

Links

• Espacenet
• Global Dossier
• Discuss

• 201000010153 skin papilloma Diseases 0.000 claims description 25
• 239000000284 extract Substances 0.000 claims description 17
• 239000009538 yokuinin Substances 0.000 claims description 16
• 208000000260 Warts Diseases 0.000 claims description 10
• 239000007788 liquid Substances 0.000 claims description 8
• 239000004480 active ingredient Substances 0.000 claims description 5
• 239000003814 drug Substances 0.000 claims description 5
• 229940124597 therapeutic agent Drugs 0.000 claims description 4
• 230000003612 virological effect Effects 0.000 claims description 3
• 239000003795 chemical substances by application Substances 0.000 claims description 2
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 15
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
• 239000007924 injection Substances 0.000 description 8
• 238000002347 injection Methods 0.000 description 8
• 239000002674 ointment Substances 0.000 description 7
• 239000000243 solution Substances 0.000 description 7
• 239000002904 solvent Substances 0.000 description 7
• 238000000034 method Methods 0.000 description 6
• 239000003960 organic solvent Substances 0.000 description 6
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
• 244000077995 Coix lacryma jobi Species 0.000 description 4
• 230000000694 effects Effects 0.000 description 3
• 238000001914 filtration Methods 0.000 description 3
• 238000002523 gelfiltration Methods 0.000 description 3
• 239000000843 powder Substances 0.000 description 3
• 238000002360 preparation method Methods 0.000 description 3
• 238000002560 therapeutic procedure Methods 0.000 description 3
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
• 102000014150 Interferons Human genes 0.000 description 2
• 108010050904 Interferons Proteins 0.000 description 2
• CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 2
• 208000004880 Polyuria Diseases 0.000 description 2
• 229920005654 Sephadex Polymers 0.000 description 2
• 239000012507 Sephadex™ Substances 0.000 description 2
• 206010000496 acne Diseases 0.000 description 2
• 239000006071 cream Substances 0.000 description 2
• 238000010586 diagram Methods 0.000 description 2
• 230000035619 diuresis Effects 0.000 description 2
• 238000010828 elution Methods 0.000 description 2
• 238000000605 extraction Methods 0.000 description 2
• 241000411851 herbal medicine Species 0.000 description 2
• 229940079322 interferon Drugs 0.000 description 2
• 239000000203 mixture Substances 0.000 description 2
• 239000003883 ointment base Substances 0.000 description 2
• 239000002504 physiological saline solution Substances 0.000 description 2
• 108090000623 proteins and genes Proteins 0.000 description 2
• 102000004169 proteins and genes Human genes 0.000 description 2
• 230000001225 therapeutic effect Effects 0.000 description 2
• 208000002874 Acne Vulgaris Diseases 0.000 description 1
• KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 description 1
• 108010006654 Bleomycin Proteins 0.000 description 1
• 235000007354 Coix lacryma jobi Nutrition 0.000 description 1
• 241001631646 Papillomaviridae Species 0.000 description 1
• 230000003110 anti-inflammatory effect Effects 0.000 description 1
• 230000036528 appetite Effects 0.000 description 1
• 235000019789 appetite Nutrition 0.000 description 1
• 229960001561 bleomycin Drugs 0.000 description 1
• OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 1
• 239000003518 caustics Substances 0.000 description 1
• 238000005119 centrifugation Methods 0.000 description 1
• FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 1
• 201000004196 common wart Diseases 0.000 description 1
• 239000012141 concentrate Substances 0.000 description 1
• 230000001143 conditioned effect Effects 0.000 description 1
• 235000009508 confectionery Nutrition 0.000 description 1
• 238000000315 cryotherapy Methods 0.000 description 1
• 230000029087 digestion Effects 0.000 description 1
• 229940079593 drug Drugs 0.000 description 1
• 239000003480 eluent Substances 0.000 description 1
• 230000003628 erosive effect Effects 0.000 description 1
• 235000013305 food Nutrition 0.000 description 1
• 229960004949 glycyrrhizic acid Drugs 0.000 description 1
• 235000019410 glycyrrhizin Nutrition 0.000 description 1
• LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
• 230000036541 health Effects 0.000 description 1
• 238000007654 immersion Methods 0.000 description 1
• 230000007233 immunological mechanism Effects 0.000 description 1
• 208000015181 infectious disease Diseases 0.000 description 1
• 230000000968 intestinal effect Effects 0.000 description 1
• 239000000395 magnesium oxide Substances 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 239000002808 molecular sieve Substances 0.000 description 1
• 229910052757 nitrogen Inorganic materials 0.000 description 1
• 230000000144 pharmacologic effect Effects 0.000 description 1
• 238000000554 physical therapy Methods 0.000 description 1
• 238000005498 polishing Methods 0.000 description 1
• 239000002244 precipitate Substances 0.000 description 1
• 239000002994 raw material Substances 0.000 description 1
• 229920006298 saran Polymers 0.000 description 1
• URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
• 101150008563 spir gene Proteins 0.000 description 1
• 238000003756 stirring Methods 0.000 description 1
• 210000002784 stomach Anatomy 0.000 description 1
• 239000000126 substance Substances 0.000 description 1
• 238000009121 systemic therapy Methods 0.000 description 1
• DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
• 230000000699 topical effect Effects 0.000 description 1
• 239000011691 vitamin B1 Substances 0.000 description 1
• 239000011715 vitamin B12 Substances 0.000 description 1