JPH0429680B2 - - Google Patents

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Publication number
JPH0429680B2
JPH0429680B2 JP58044509A JP4450983A JPH0429680B2 JP H0429680 B2 JPH0429680 B2 JP H0429680B2 JP 58044509 A JP58044509 A JP 58044509A JP 4450983 A JP4450983 A JP 4450983A JP H0429680 B2 JPH0429680 B2 JP H0429680B2
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JP
Japan
Prior art keywords
blood coagulation
factor
polyethylene glycol
molecular weight
coagulation factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP58044509A
Other languages
English (en)
Japanese (ja)
Other versions
JPS59172425A (ja
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to JP58044509A priority Critical patent/JPS59172425A/ja
Publication of JPS59172425A publication Critical patent/JPS59172425A/ja
Publication of JPH0429680B2 publication Critical patent/JPH0429680B2/ja
Granted legal-status Critical Current

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP58044509A 1983-03-18 1983-03-18 新規な血液凝固因子誘導体およびその製造法ならびにそれを含有する血液凝固促進剤 Granted JPS59172425A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP58044509A JPS59172425A (ja) 1983-03-18 1983-03-18 新規な血液凝固因子誘導体およびその製造法ならびにそれを含有する血液凝固促進剤

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58044509A JPS59172425A (ja) 1983-03-18 1983-03-18 新規な血液凝固因子誘導体およびその製造法ならびにそれを含有する血液凝固促進剤

Publications (2)

Publication Number Publication Date
JPS59172425A JPS59172425A (ja) 1984-09-29
JPH0429680B2 true JPH0429680B2 (enExample) 1992-05-19

Family

ID=12693520

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58044509A Granted JPS59172425A (ja) 1983-03-18 1983-03-18 新規な血液凝固因子誘導体およびその製造法ならびにそれを含有する血液凝固促進剤

Country Status (1)

Country Link
JP (1) JPS59172425A (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9503380D0 (sv) * 1995-09-29 1995-09-29 Pharmacia Ab Protein derivatives
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
EP1596887B1 (en) 2003-02-26 2022-03-23 Nektar Therapeutics Polymer-factor viii moiety conjugates
CA2522345A1 (en) 2003-04-09 2004-11-18 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
JP4738346B2 (ja) * 2003-12-03 2011-08-03 ノヴォ ノルディスク アー／エス ＧｌｙｃｏＰＥＧ化された第ＩＸ因子
JP2008505119A (ja) * 2004-06-30 2008-02-21 ネクター セラピューティクス アラバマ，コーポレイション 高分子−第ｉｘ因子部分の抱合体
AU2014280936B2 (en) * 2004-06-30 2016-12-15 Nektar Therapeutics Polymer-factor ix moiety conjugates
WO2006010143A2 (en) 2004-07-13 2006-01-26 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
EP1814573B1 (en) 2004-10-29 2016-03-09 ratiopharm GmbH Remodeling and glycopegylation of fibroblast growth factor (fgf)
DK2371856T3 (en) * 2004-11-12 2022-08-08 Bayer Healthcare Llc Site-directed modifikation af FVIII
AU2005322067B8 (en) * 2004-12-27 2012-07-26 Takeda Pharmaceutical Company Limited Polymer-von Willebrand factor-conjugates
CA2593682C (en) 2005-01-10 2016-03-22 Neose Technologies, Inc. Glycopegylated granulocyte colony stimulating factor
US9187546B2 (en) 2005-04-08 2015-11-17 Novo Nordisk A/S Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
CN101516388B (zh) 2006-07-21 2012-10-31 诺和诺德公司 通过o-联糖基化序列的肽的糖基化
US8969532B2 (en) 2006-10-03 2015-03-03 Novo Nordisk A/S Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
EP2144923B1 (en) 2007-04-03 2013-02-13 BioGeneriX AG Methods of treatment using glycopegylated g-csf
WO2008154639A2 (en) 2007-06-12 2008-12-18 Neose Technologies, Inc. Improved process for the production of nucleotide sugars
US20130189239A1 (en) 2008-02-27 2013-07-25 Novo Nordisk A/S Conjugated Factor VIII Molecules

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5959629A (ja) * 1982-09-27 1984-04-05 Nippon Chem Res Kk 効力持続性組成物
JPS6042087A (ja) * 1983-08-19 1985-03-06 Nec Corp プリンタ

Also Published As

Publication number Publication date
JPS59172425A (ja) 1984-09-29

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