JPH0374662B2 - - Google Patents
Info
- Publication number
- JPH0374662B2 JPH0374662B2 JP27138485A JP27138485A JPH0374662B2 JP H0374662 B2 JPH0374662 B2 JP H0374662B2 JP 27138485 A JP27138485 A JP 27138485A JP 27138485 A JP27138485 A JP 27138485A JP H0374662 B2 JPH0374662 B2 JP H0374662B2
- Authority
- JP
- Japan
- Prior art keywords
- methoxyphenyl
- dihydro
- dimethylamino
- ethyl
- hydrochloric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 24
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims description 18
- 238000006243 chemical reaction Methods 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 5
- NZHUXMZTSSZXSB-UHFFFAOYSA-N 5-[2-(dimethylamino)ethyl]-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4-one Chemical compound C1=CC(OC)=CC=C1C1C(O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 NZHUXMZTSSZXSB-UHFFFAOYSA-N 0.000 claims description 3
- HDRXZJPWHTXQRI-UHFFFAOYSA-N 2-[3-acetyloxy-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-5-yl]ethyl-dimethylazanium;chloride Chemical compound Cl.C1=CC(OC)=CC=C1C1C(OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HDRXZJPWHTXQRI-UHFFFAOYSA-N 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- -1 3-acetoxy-5-[2-(dimethylamino)ethyl]-2-(p-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepine Chemical compound 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- LKAOPBFMTSRRQE-UHFFFAOYSA-N 5H-1,5-benzothiazepin-4-one hydrochloride Chemical compound Cl.S1C=CC(=O)NC2=CC=CC=C21 LKAOPBFMTSRRQE-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- FUKUFMFMCZIRNT-UHFFFAOYSA-N hydron;methanol;chloride Chemical compound Cl.OC FUKUFMFMCZIRNT-UHFFFAOYSA-N 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- PPQXADXGECUTFI-UHFFFAOYSA-N 5h-1,5-benzothiazepin-4-one Chemical compound S1C=CC(=O)NC2=CC=CC=C21 PPQXADXGECUTFI-UHFFFAOYSA-N 0.000 description 1
- ZYRCHUVJSSOZBR-UHFFFAOYSA-N Cl.C1=CC(OC)=CC=C1C1SC2=CC=CC=C2NC(=O)C1 Chemical compound Cl.C1=CC(OC)=CC=C1C1SC2=CC=CC=C2NC(=O)C1 ZYRCHUVJSSOZBR-UHFFFAOYSA-N 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 230000021736 acetylation Effects 0.000 description 1
- 238000006640 acetylation reaction Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27138485A JPS62132876A (ja) | 1985-12-04 | 1985-12-04 | １，５−ベンゾチアゼピン誘導体の製法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27138485A JPS62132876A (ja) | 1985-12-04 | 1985-12-04 | １，５−ベンゾチアゼピン誘導体の製法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62132876A JPS62132876A (ja) | 1987-06-16 |
| JPH0374662B2 true JPH0374662B2 (cs) | 1991-11-27 |
Family
ID=17499318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP27138485A Granted JPS62132876A (ja) | 1985-12-04 | 1985-12-04 | １，５−ベンゾチアゼピン誘導体の製法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62132876A (cs) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL100157A (en) * | 1990-11-29 | 1995-12-08 | Tanabe Seiyaku Co | Preparation of a result of 1,5-benzothiazepine |
-
1985
- 1985-12-04 JP JP27138485A patent/JPS62132876A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62132876A (ja) | 1987-06-16 |
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