JPH036140B2 - - Google Patents

Info

Publication number
JPH036140B2
JPH036140B2 JP56057855A JP5785581A JPH036140B2 JP H036140 B2 JPH036140 B2 JP H036140B2 JP 56057855 A JP56057855 A JP 56057855A JP 5785581 A JP5785581 A JP 5785581A JP H036140 B2 JPH036140 B2 JP H036140B2
Authority
JP
Japan
Prior art keywords
group
general formula
ester
methyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP56057855A
Other languages
English (en)
Japanese (ja)
Other versions
JPS57175164A (en
Inventor
Tetsuji Myano
Kunio Suzuki
Nobuo Harada
Hikari Asai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Priority to JP56057855A priority Critical patent/JPS57175164A/ja
Priority to DE8282103145T priority patent/DE3267874D1/de
Priority to EP82103145A priority patent/EP0063359B1/en
Priority to HU821144A priority patent/HU186494B/hu
Priority to CA000401133A priority patent/CA1176255A/en
Priority to KR8201696A priority patent/KR900004923B1/ko
Publication of JPS57175164A publication Critical patent/JPS57175164A/ja
Publication of JPH036140B2 publication Critical patent/JPH036140B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP56057855A 1981-04-18 1981-04-18 1,4-dihydropyridine derivative and its preparation Granted JPS57175164A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP56057855A JPS57175164A (en) 1981-04-18 1981-04-18 1,4-dihydropyridine derivative and its preparation
DE8282103145T DE3267874D1 (en) 1981-04-18 1982-04-14 1,4-dihydropyridine derivatives and processes for preparing the same
EP82103145A EP0063359B1 (en) 1981-04-18 1982-04-14 1,4-dihydropyridine derivatives and processes for preparing the same
HU821144A HU186494B (en) 1981-04-18 1982-04-15 Process for producing new 1,4-dihydropyridine derivatives
CA000401133A CA1176255A (en) 1981-04-18 1982-04-16 1,4-dihydropyridine derivatives and processes for preparing the same
KR8201696A KR900004923B1 (ko) 1981-04-18 1982-04-17 1,4-디히드로피리딘 유도체의 제조방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56057855A JPS57175164A (en) 1981-04-18 1981-04-18 1,4-dihydropyridine derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS57175164A JPS57175164A (en) 1982-10-28
JPH036140B2 true JPH036140B2 (en, 2012) 1991-01-29

Family

ID=13067598

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56057855A Granted JPS57175164A (en) 1981-04-18 1981-04-18 1,4-dihydropyridine derivative and its preparation

Country Status (6)

Country Link
EP (1) EP0063359B1 (en, 2012)
JP (1) JPS57175164A (en, 2012)
KR (1) KR900004923B1 (en, 2012)
CA (1) CA1176255A (en, 2012)
DE (1) DE3267874D1 (en, 2012)
HU (1) HU186494B (en, 2012)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4686217A (en) * 1983-04-27 1987-08-11 Fisons Plc Calcium antagonist 2-fluoroalkyl-1,4-dihydropyridines
EP0125803A3 (en) * 1983-04-27 1987-01-21 FISONS plc Pharmaceutically active dihydropyridines
JPS60120861A (ja) * 1983-12-02 1985-06-28 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体
JPS60156671A (ja) * 1984-01-25 1985-08-16 Yamanouchi Pharmaceut Co Ltd ジヒドロピリジン誘導体およびその製造法
US4672068A (en) * 1984-05-04 1987-06-09 Fujirebio Kabushiki Kaisha Antihypertensive 1,4-dihydropyridines having a conjugated ester
US6265127B1 (en) * 1999-12-15 2001-07-24 Eastman Kodak Company 1, 4-dihydrophyridine charge control agents for electrostatographic toners and developers

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5084577A (en, 2012) * 1973-11-29 1975-07-08
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
GB1591089A (en) * 1976-12-17 1981-06-10 Fujisawa Pharmaceutical Co 1,4-dihydropyridine derivatives and process for preparation thereof
DE2650013C3 (de) * 1976-10-30 1981-04-02 Bayer Ag, 5090 Leverkusen 1.4-Dihydro-2.6-dimethyl-4-(3-nitrophenyl)-3.5-pyridindicarbonsäureisopropyl-(2-propoxy-äthyl)-ester, Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel
US4307103A (en) * 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
CA1117117A (en) * 1978-10-10 1982-01-26 Fujisawa Pharmaceutical Co., Ltd. 2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
CA1176255A (en) 1984-10-16
HU186494B (en) 1985-08-28
DE3267874D1 (en) 1986-01-23
EP0063359B1 (en) 1985-12-11
KR900004923B1 (ko) 1990-07-12
JPS57175164A (en) 1982-10-28
KR830010073A (ko) 1983-12-26
EP0063359A1 (en) 1982-10-27

Similar Documents

Publication Publication Date Title
IE57715B1 (en) Asymmetrical diesters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid
KR920005742B1 (ko) 약제학상 유용한 디하이드로피리디닐디카르복실레이트 아마이드 및 에스테르의 제조방법
JPS62192359A (ja) １，４−ジヒドロピリジン化合物の製法
HUP0100640A2 (hu) Eljárás 1,4-dihidropiridinek előállítására
JPH036140B2 (en, 2012)
JPH0128746B2 (en, 2012)
JP4031366B2 (ja) アムロジピンの製造方法
US4579859A (en) Vasodilating trinitratoalkyl esters of 2-cyano-1,4-dihydropyridines
JPH0314020B2 (en, 2012)
JP3100444B2 (ja) １，４−ジヒドロピリジン誘導体及びその製造方法
JP2640245B2 (ja) １，４−ジヒドロピリジン誘導体
US4742068A (en) Dihydropyridine compounds having 1,4,4-trisubstitution useful as antihypertensive agents
JPS6330304B2 (en, 2012)
EP0220917B1 (en) 1,4-dihydropyridine pharmaceutical derivatives and their salts, and the preparation thereof
JPH0641063A (ja) ピロリジン誘導体
JPS6352031B2 (en, 2012)
JP3006904B2 (ja) １，４−ジヒドロピリジン誘導体の製造法及びその中間体
JPH0128020B2 (en, 2012)
JPH07215965A (ja) インドールスルホンアミド−置換ジヒドロピリジン類
JPH0527624B2 (en, 2012)
JPH072774A (ja) ジヒドロピリジン誘導体、その製造法、該誘導体を含有する医薬組成物および高血圧症の治療薬の製造を目的とする該誘導体の使用方法
EP0127150A2 (en) 2,6-Disubstituted-1,4-dihydropyridine derivative, process for the preparation of the same and pharmaceutical composition comprising the same
JPH02149562A (ja) 相間移動触媒を用いた１，４−ジヒドロピリジン誘導体の製造方法
JPS6321674B2 (en, 2012)
EP0280239A1 (en) 1,4-Dihydropyridine derivatives, production and use thereof