JPH0351702B2 - - Google Patents

Info

Publication number
JPH0351702B2
JPH0351702B2 JP62292234A JP29223487A JPH0351702B2 JP H0351702 B2 JPH0351702 B2 JP H0351702B2 JP 62292234 A JP62292234 A JP 62292234A JP 29223487 A JP29223487 A JP 29223487A JP H0351702 B2 JPH0351702 B2 JP H0351702B2
Authority
JP
Japan
Prior art keywords
acid
mol
hours
formula
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP62292234A
Other languages
English (en)
Japanese (ja)
Other versions
JPS63183558A (ja
Inventor
Jirai Junesu
Fuutomatsuhaa Kurausu
Kureeman Akuseru
Riito Toomasu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asta Medica GmbH
Original Assignee
Asta Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Pharma AG filed Critical Asta Pharma AG
Publication of JPS63183558A publication Critical patent/JPS63183558A/ja
Publication of JPH0351702B2 publication Critical patent/JPH0351702B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP62292234A 1985-04-11 1987-11-20 ８−チオ−オクタン酸 Granted JPS63183558A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853512911 DE3512911A1 (de) 1985-04-11 1985-04-11 Verfahren zur herstellung von 1,2-dithiolan-3-pentansaeure (thioctsaeure)
DE3512911.5 1985-04-11

Publications (2)

Publication Number Publication Date
JPS63183558A JPS63183558A (ja) 1988-07-28
JPH0351702B2 true JPH0351702B2 (en, 2012) 1991-08-07

Family

ID=6267677

Family Applications (2)

Application Number Title Priority Date Filing Date
JP61080291A Granted JPS61236775A (ja) 1985-04-11 1986-04-09 １，２‐ジチオラン‐３‐ペンタン酸の製法
JP62292234A Granted JPS63183558A (ja) 1985-04-11 1987-11-20 ８−チオ−オクタン酸

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP61080291A Granted JPS61236775A (ja) 1985-04-11 1986-04-09 １，２‐ジチオラン‐３‐ペンタン酸の製法

Country Status (9)

Country Link
US (3) US4705867A (en, 2012)
EP (1) EP0197407B1 (en, 2012)
JP (2) JPS61236775A (en, 2012)
AT (1) ATE47138T1 (en, 2012)
DD (1) DD251750A5 (en, 2012)
DE (2) DE3512911A1 (en, 2012)
ES (1) ES8703451A1 (en, 2012)
FI (1) FI861506A7 (en, 2012)
HU (1) HUT40638A (en, 2012)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3629116A1 (de) * 1986-08-27 1988-03-10 Asta Pharma Ag Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer
PT95827B (pt) * 1989-11-09 1997-11-28 Asta Medica Ag Processo para a preparacao de composicoes farmaceuticas para combater retrovirus, contendo como ingredientes activos acidos carboxilicos com enxofre
ATE163849T1 (de) 1989-11-09 1998-03-15 Asta Medica Ag Arzneimittel enthaltend als wirkstoff r-alpha- liponsäure oder s-alpha-liponsäure
DE4037440A1 (de) * 1990-11-24 1992-05-27 Basf Ag Verfahren zur herstellung von (6s)-6,8-dihydroxyoctansaeureestern
DE4229914A1 (de) * 1992-09-08 1994-03-10 Basf Ag Verbessertes Verfahren zur Herstellung von R/S-Ï-Liponsäure oder R/S-â-Liponsäure
DE9213914U1 (de) * 1992-10-15 1992-12-03 Asta Medica AG, 6000 Frankfurt Ampulle und Infusionslösung von Thioctsäure in Form der wasserlöslichen Salze der Thioctsäure
EP0855396A1 (en) * 1997-01-22 1998-07-29 ASTA Medica Aktiengesellschaft Thioctic acid metabolites and methods of use thereof
US6197340B1 (en) * 1998-05-28 2001-03-06 Medical Research Institute Controlled release lipoic acid
US6905707B2 (en) * 1998-05-28 2005-06-14 Medical Research Institute Controlled release arginine alpha ketoglutarate
US6191162B1 (en) 1998-05-28 2001-02-20 Medical Research Institute Method of reducing serum glucose levels
US20040259895A1 (en) * 1998-05-28 2004-12-23 Medical Research Institute Oral formulation of lipid soluble thiamine and lipoic acid
US20050085498A1 (en) * 1998-05-28 2005-04-21 Byrd Edward A. Oral formulation of lipid soluble thiamine, lipoic acid, creatine derivative, and L-arginine alpha-ketoglutarate
JP4728481B2 (ja) * 1998-10-26 2011-07-20 ザ リサーチ ファウンデーション オブ ステイト ユニバーシティ オブ ニューヨーク リポ酸誘導体および疾患の治療におけるそれら誘導体の使用
US6664287B2 (en) * 2000-03-15 2003-12-16 Bethesda Pharmaceuticals, Inc. Antioxidants
US20070272320A1 (en) * 2006-05-24 2007-11-29 James Roberson Reusable duct wrap
US8263653B2 (en) 2007-04-18 2012-09-11 Cornerstone Pharmaceuticals, Inc. Pharmaceutical formulations containing lipoic acid derivatives
ES2528414T3 (es) 2007-04-18 2015-02-10 Cornerstone Pharmaceuticals, Inc. Formulaciones farmacéuticas que contienen derivados de ácido lipoico
US8785475B2 (en) 2007-04-18 2014-07-22 Cornerstone Pharmaceuticals, Inc. Lipoic acid derivatives
JP2012510511A (ja) * 2008-12-01 2012-05-10 インヴアスク セラピューテイックス インコーポレイテッド レニン−アンジオテンシン−アルドステロン系阻害剤及びリポ酸化合物を含有する組成物、並びに、レニン−アンジオテンシン−アルドステロン系に関連した疾患の治療のためのそれらの使用
AU2014398233B2 (en) 2014-06-19 2019-11-28 Rafael Pharmaceuticals, Inc. Pharmaceutical compounds
CA2965963A1 (en) 2014-06-19 2015-12-23 Robert Shorr Lipoic acid derivatives for pharmaceutical use

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB762575A (en) * 1952-04-24 1956-11-28 American Cyanamid Co Omega [3-(1,2-dithiolanyl)] aliphatic acids, salts and esters and the preparation thereof
US2752374A (en) * 1952-12-10 1956-06-26 Du Pont Preparation of acids having thiol groups on the ultimate and antepenultimate carbons from the carboxyl
US2752373A (en) * 1952-12-10 1956-06-26 Du Pont Process for preparing 6, 8-dithiooctanoic acid
US2828322A (en) * 1953-10-19 1958-03-25 American Cyanamid Co Hydroxy thioaliphatic acids and methods of preparing the same
US2828321A (en) * 1953-10-19 1958-03-25 American Cyanamid Co Keto aliphatic acid esters and method of preparing the same
US2809978A (en) * 1953-12-04 1957-10-15 Merck & Co Inc Intermediates useful in the synthesis of alpha-lipoic acid
US2853497A (en) * 1953-12-04 1958-09-23 Merck & Co Inc 6, 8-bis (hydrocarbon substituted mercapto) 5-hydroxycaprylic acids and delta-lactones thereof
US3002011A (en) * 1953-12-04 1961-09-26 Merck & Co Inc Intermediates and processes for producing alpha-lipoic acid
US3049549A (en) * 1954-03-22 1962-08-14 Research Corp Lipoic acid and derivatives
US2789991A (en) * 1954-05-20 1957-04-23 American Cyanamid Co Substituted disulfones
US2792406A (en) * 1954-06-01 1957-05-14 Du Pont Process of preparing alpha-lipoic acid using dichlorooctanoate and metal disulfide
US2980716A (en) * 1954-06-11 1961-04-18 Research Corp Method for preparing 6, 8-dihalooctanoic esters
US2975198A (en) * 1954-07-08 1961-03-14 Research Corp Lipoic acid intermediates
US3033882A (en) * 1958-04-17 1962-05-08 Rech S Et Propagande Scient Octanoic esters and processes for their preparation and utilization
US3223712A (en) * 1960-07-18 1965-12-14 Yamanouchi Pharma Co Ltd Synthesis of thioctic acid and thioctic acid amide

Also Published As

Publication number Publication date
ES553850A0 (es) 1987-02-16
US4966732A (en) 1990-10-30
JPS63183558A (ja) 1988-07-28
EP0197407B1 (de) 1989-10-11
DD251750A5 (de) 1987-11-25
FI861506A0 (fi) 1986-04-09
FI861506A7 (fi) 1986-10-12
JPS61236775A (ja) 1986-10-22
EP0197407A3 (en) 1987-09-02
DE3666226D1 (en) 1989-11-16
EP0197407A2 (de) 1986-10-15
ES8703451A1 (es) 1987-02-16
US4800044A (en) 1989-01-24
ATE47138T1 (de) 1989-10-15
DE3512911A1 (de) 1986-10-16
US4705867A (en) 1987-11-10
HUT40638A (en) 1987-01-28
JPH0348188B2 (en, 2012) 1991-07-23

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