ES553850A0 - Procedimiento para preparar acido 1,2-ditiolan-3-pentanoico (acido tioctico) - Google Patents

Procedimiento para preparar acido 1,2-ditiolan-3-pentanoico (acido tioctico)

Info

Publication number
ES553850A0
ES553850A0 ES553850A ES553850A ES553850A0 ES 553850 A0 ES553850 A0 ES 553850A0 ES 553850 A ES553850 A ES 553850A ES 553850 A ES553850 A ES 553850A ES 553850 A0 ES553850 A0 ES 553850A0
Authority
ES
Spain
Prior art keywords
acid
ditiolan
preparing
procedure
thioctic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES553850A
Other languages
English (en)
Other versions
ES8703451A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH filed Critical Degussa GmbH
Publication of ES553850A0 publication Critical patent/ES553850A0/es
Publication of ES8703451A1 publication Critical patent/ES8703451A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ES553850A 1985-04-11 1986-04-10 Procedimiento para preparar acido 1,2-ditiolan-3-pentanoico (acido tioctico) Expired ES8703451A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853512911 DE3512911A1 (de) 1985-04-11 1985-04-11 Verfahren zur herstellung von 1,2-dithiolan-3-pentansaeure (thioctsaeure)

Publications (2)

Publication Number Publication Date
ES553850A0 true ES553850A0 (es) 1987-02-16
ES8703451A1 ES8703451A1 (es) 1987-02-16

Family

ID=6267677

Family Applications (1)

Application Number Title Priority Date Filing Date
ES553850A Expired ES8703451A1 (es) 1985-04-11 1986-04-10 Procedimiento para preparar acido 1,2-ditiolan-3-pentanoico (acido tioctico)

Country Status (9)

Country Link
US (3) US4705867A (es)
EP (1) EP0197407B1 (es)
JP (2) JPS61236775A (es)
AT (1) ATE47138T1 (es)
DD (1) DD251750A5 (es)
DE (2) DE3512911A1 (es)
ES (1) ES8703451A1 (es)
FI (1) FI861506A (es)
HU (1) HUT40638A (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3629116A1 (de) * 1986-08-27 1988-03-10 Asta Pharma Ag Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer
IE67874B1 (en) * 1989-11-09 1996-05-01 Asta Medica Ag Medicaments containing as active substance sulphur-containing carboxylic acids and their use in combating retroviruses
DK0427247T3 (da) * 1989-11-09 1998-09-28 Asta Medica Ag Lægemiddel indeholdende R-alpha- lipoinsyre eller S-alphalipoinsyre som aktiv bestanddel
DE4037440A1 (de) * 1990-11-24 1992-05-27 Basf Ag Verfahren zur herstellung von (6s)-6,8-dihydroxyoctansaeureestern
DE4229914A1 (de) * 1992-09-08 1994-03-10 Basf Ag Verbessertes Verfahren zur Herstellung von R/S-Ï-Liponsäure oder R/S-â-Liponsäure
DE9213914U1 (de) * 1992-10-15 1992-12-03 Asta Medica AG, 6000 Frankfurt Ampulle und Infusionslösung von Thioctsäure in Form der wasserlöslichen Salze der Thioctsäure
EP0855396A1 (en) * 1997-01-22 1998-07-29 ASTA Medica Aktiengesellschaft Thioctic acid metabolites and methods of use thereof
US20050085498A1 (en) * 1998-05-28 2005-04-21 Byrd Edward A. Oral formulation of lipid soluble thiamine, lipoic acid, creatine derivative, and L-arginine alpha-ketoglutarate
US6905707B2 (en) * 1998-05-28 2005-06-14 Medical Research Institute Controlled release arginine alpha ketoglutarate
US20040259895A1 (en) * 1998-05-28 2004-12-23 Medical Research Institute Oral formulation of lipid soluble thiamine and lipoic acid
US6191162B1 (en) 1998-05-28 2001-02-20 Medical Research Institute Method of reducing serum glucose levels
US6197340B1 (en) * 1998-05-28 2001-03-06 Medical Research Institute Controlled release lipoic acid
BR9914789A (pt) * 1998-10-26 2001-10-02 Univ New York State Res Found Derivados de ácido lipóico e seus usos no tratamento de doença
US6664287B2 (en) * 2000-03-15 2003-12-16 Bethesda Pharmaceuticals, Inc. Antioxidants
US20070272320A1 (en) * 2006-05-24 2007-11-29 James Roberson Reusable duct wrap
ES2528414T3 (es) 2007-04-18 2015-02-10 Cornerstone Pharmaceuticals, Inc. Formulaciones farmacéuticas que contienen derivados de ácido lipoico
US8263653B2 (en) 2007-04-18 2012-09-11 Cornerstone Pharmaceuticals, Inc. Pharmaceutical formulations containing lipoic acid derivatives
KR101644192B1 (ko) 2007-04-18 2016-07-29 코너스톤 파마슈티칼스, 인크. 리포산 유도체
KR20110103987A (ko) * 2008-12-01 2011-09-21 인베이스크 테라퓨틱, 인크. 레닌-안지오텐신 알도스테론계 억제제 및 리포산 화합물을 포함하는 조성물, 및 레닌-안지오텐신 알도스테론계 관련 질환의 치료를 위한 이의 용도
WO2015195071A1 (en) 2014-06-19 2015-12-23 Robert Shorr Pharmaceutical compounds
AU2014398232B2 (en) 2014-06-19 2019-11-28 Rafael Pharmaceuticals, Inc. Pharmaceutical compounds

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB762575A (en) * 1952-04-24 1956-11-28 American Cyanamid Co Omega [3-(1,2-dithiolanyl)] aliphatic acids, salts and esters and the preparation thereof
US2752373A (en) * 1952-12-10 1956-06-26 Du Pont Process for preparing 6, 8-dithiooctanoic acid
US2752374A (en) * 1952-12-10 1956-06-26 Du Pont Preparation of acids having thiol groups on the ultimate and antepenultimate carbons from the carboxyl
US2828322A (en) * 1953-10-19 1958-03-25 American Cyanamid Co Hydroxy thioaliphatic acids and methods of preparing the same
US2828321A (en) * 1953-10-19 1958-03-25 American Cyanamid Co Keto aliphatic acid esters and method of preparing the same
US3002011A (en) * 1953-12-04 1961-09-26 Merck & Co Inc Intermediates and processes for producing alpha-lipoic acid
US2853497A (en) * 1953-12-04 1958-09-23 Merck & Co Inc 6, 8-bis (hydrocarbon substituted mercapto) 5-hydroxycaprylic acids and delta-lactones thereof
US2809978A (en) * 1953-12-04 1957-10-15 Merck & Co Inc Intermediates useful in the synthesis of alpha-lipoic acid
US3049549A (en) * 1954-03-22 1962-08-14 Research Corp Lipoic acid and derivatives
US2789991A (en) * 1954-05-20 1957-04-23 American Cyanamid Co Substituted disulfones
US2792406A (en) * 1954-06-01 1957-05-14 Du Pont Process of preparing alpha-lipoic acid using dichlorooctanoate and metal disulfide
US2980716A (en) * 1954-06-11 1961-04-18 Research Corp Method for preparing 6, 8-dihalooctanoic esters
US2975198A (en) * 1954-07-08 1961-03-14 Research Corp Lipoic acid intermediates
US3033882A (en) * 1958-04-17 1962-05-08 Rech S Et Propagande Scient Octanoic esters and processes for their preparation and utilization
US3223712A (en) * 1960-07-18 1965-12-14 Yamanouchi Pharma Co Ltd Synthesis of thioctic acid and thioctic acid amide

Also Published As

Publication number Publication date
DE3512911A1 (de) 1986-10-16
DD251750A5 (de) 1987-11-25
JPH0348188B2 (es) 1991-07-23
ES8703451A1 (es) 1987-02-16
EP0197407A2 (de) 1986-10-15
FI861506A (fi) 1986-10-12
ATE47138T1 (de) 1989-10-15
EP0197407B1 (de) 1989-10-11
HUT40638A (en) 1987-01-28
US4705867A (en) 1987-11-10
JPH0351702B2 (es) 1991-08-07
US4966732A (en) 1990-10-30
JPS63183558A (ja) 1988-07-28
FI861506A0 (fi) 1986-04-09
US4800044A (en) 1989-01-24
JPS61236775A (ja) 1986-10-22
EP0197407A3 (en) 1987-09-02
DE3666226D1 (en) 1989-11-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20100528