HUT40638A - Process for producing 1,2-dithiolane-3-pentanoic acid - Google Patents
Process for producing 1,2-dithiolane-3-pentanoic acidInfo
- Publication number
- HUT40638A HUT40638A HU861516A HU151686A HUT40638A HU T40638 A HUT40638 A HU T40638A HU 861516 A HU861516 A HU 861516A HU 151686 A HU151686 A HU 151686A HU T40638 A HUT40638 A HU T40638A
- Authority
- HU
- Hungary
- Prior art keywords
- dithiolane
- pentanoic acid
- producing
- xii
- image
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19853512911 DE3512911A1 (de) | 1985-04-11 | 1985-04-11 | Verfahren zur herstellung von 1,2-dithiolan-3-pentansaeure (thioctsaeure) |
Publications (1)
Publication Number | Publication Date |
---|---|
HUT40638A true HUT40638A (en) | 1987-01-28 |
Family
ID=6267677
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU861516A HUT40638A (en) | 1985-04-11 | 1986-04-10 | Process for producing 1,2-dithiolane-3-pentanoic acid |
Country Status (9)
Country | Link |
---|---|
US (3) | US4705867A (hu) |
EP (1) | EP0197407B1 (hu) |
JP (2) | JPS61236775A (hu) |
AT (1) | ATE47138T1 (hu) |
DD (1) | DD251750A5 (hu) |
DE (2) | DE3512911A1 (hu) |
ES (1) | ES8703451A1 (hu) |
FI (1) | FI861506A (hu) |
HU (1) | HUT40638A (hu) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3629116A1 (de) * | 1986-08-27 | 1988-03-10 | Asta Pharma Ag | Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer |
JPH03188021A (ja) * | 1989-11-09 | 1991-08-16 | Asta Pharma Ag | レトロウイルスを撲滅するための医薬品およびその製造法 |
DK0427247T3 (da) * | 1989-11-09 | 1998-09-28 | Asta Medica Ag | Lægemiddel indeholdende R-alpha- lipoinsyre eller S-alphalipoinsyre som aktiv bestanddel |
DE4037440A1 (de) * | 1990-11-24 | 1992-05-27 | Basf Ag | Verfahren zur herstellung von (6s)-6,8-dihydroxyoctansaeureestern |
DE4229914A1 (de) * | 1992-09-08 | 1994-03-10 | Basf Ag | Verbessertes Verfahren zur Herstellung von R/S-Ï-Liponsäure oder R/S-â-Liponsäure |
DE9213914U1 (de) * | 1992-10-15 | 1992-12-03 | Asta Medica AG, 6000 Frankfurt | Ampulle und Infusionslösung von Thioctsäure in Form der wasserlöslichen Salze der Thioctsäure |
EP0855396A1 (en) * | 1997-01-22 | 1998-07-29 | ASTA Medica Aktiengesellschaft | Thioctic acid metabolites and methods of use thereof |
US6905707B2 (en) * | 1998-05-28 | 2005-06-14 | Medical Research Institute | Controlled release arginine alpha ketoglutarate |
US6191162B1 (en) | 1998-05-28 | 2001-02-20 | Medical Research Institute | Method of reducing serum glucose levels |
US6197340B1 (en) * | 1998-05-28 | 2001-03-06 | Medical Research Institute | Controlled release lipoic acid |
US20050085498A1 (en) * | 1998-05-28 | 2005-04-21 | Byrd Edward A. | Oral formulation of lipid soluble thiamine, lipoic acid, creatine derivative, and L-arginine alpha-ketoglutarate |
US20040259895A1 (en) * | 1998-05-28 | 2004-12-23 | Medical Research Institute | Oral formulation of lipid soluble thiamine and lipoic acid |
JP4728481B2 (ja) * | 1998-10-26 | 2011-07-20 | ザ リサーチ ファウンデーション オブ ステイト ユニバーシティ オブ ニューヨーク | リポ酸誘導体および疾患の治療におけるそれら誘導体の使用 |
US6664287B2 (en) * | 2000-03-15 | 2003-12-16 | Bethesda Pharmaceuticals, Inc. | Antioxidants |
US20070272320A1 (en) * | 2006-05-24 | 2007-11-29 | James Roberson | Reusable duct wrap |
KR101539785B1 (ko) | 2007-04-18 | 2015-07-27 | 코너스톤 파마슈티칼스, 인크. | 리포산 유도체를 함유하는 약제학적 제형 |
US8263653B2 (en) | 2007-04-18 | 2012-09-11 | Cornerstone Pharmaceuticals, Inc. | Pharmaceutical formulations containing lipoic acid derivatives |
CN101765370B (zh) | 2007-04-18 | 2014-06-25 | 基石制药公司 | 硫辛酸衍生物 |
BRPI0916476A2 (pt) * | 2008-12-01 | 2016-02-16 | Invasc Therapeutics Inc | composição, método de tratamento para um distúrbio relacionado ao sistema renina-angiotensina-aldosterona, método para reduzir a resistência à insulina, método para tratar um distúrbio relacionado à síndrome metabólica |
WO2015195071A1 (en) | 2014-06-19 | 2015-12-23 | Robert Shorr | Pharmaceutical compounds |
AU2014398232B2 (en) | 2014-06-19 | 2019-11-28 | Rafael Pharmaceuticals, Inc. | Pharmaceutical compounds |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB762575A (en) * | 1952-04-24 | 1956-11-28 | American Cyanamid Co | Omega [3-(1,2-dithiolanyl)] aliphatic acids, salts and esters and the preparation thereof |
US2752374A (en) * | 1952-12-10 | 1956-06-26 | Du Pont | Preparation of acids having thiol groups on the ultimate and antepenultimate carbons from the carboxyl |
US2752373A (en) * | 1952-12-10 | 1956-06-26 | Du Pont | Process for preparing 6, 8-dithiooctanoic acid |
US2828321A (en) * | 1953-10-19 | 1958-03-25 | American Cyanamid Co | Keto aliphatic acid esters and method of preparing the same |
US2828322A (en) * | 1953-10-19 | 1958-03-25 | American Cyanamid Co | Hydroxy thioaliphatic acids and methods of preparing the same |
US2809978A (en) * | 1953-12-04 | 1957-10-15 | Merck & Co Inc | Intermediates useful in the synthesis of alpha-lipoic acid |
US2853497A (en) * | 1953-12-04 | 1958-09-23 | Merck & Co Inc | 6, 8-bis (hydrocarbon substituted mercapto) 5-hydroxycaprylic acids and delta-lactones thereof |
US3002011A (en) * | 1953-12-04 | 1961-09-26 | Merck & Co Inc | Intermediates and processes for producing alpha-lipoic acid |
US3049549A (en) * | 1954-03-22 | 1962-08-14 | Research Corp | Lipoic acid and derivatives |
US2789991A (en) * | 1954-05-20 | 1957-04-23 | American Cyanamid Co | Substituted disulfones |
US2792406A (en) * | 1954-06-01 | 1957-05-14 | Du Pont | Process of preparing alpha-lipoic acid using dichlorooctanoate and metal disulfide |
US2980716A (en) * | 1954-06-11 | 1961-04-18 | Research Corp | Method for preparing 6, 8-dihalooctanoic esters |
US2975198A (en) * | 1954-07-08 | 1961-03-14 | Research Corp | Lipoic acid intermediates |
US3033882A (en) * | 1958-04-17 | 1962-05-08 | Rech S Et Propagande Scient | Octanoic esters and processes for their preparation and utilization |
US3223712A (en) * | 1960-07-18 | 1965-12-14 | Yamanouchi Pharma Co Ltd | Synthesis of thioctic acid and thioctic acid amide |
-
1985
- 1985-04-11 DE DE19853512911 patent/DE3512911A1/de not_active Withdrawn
-
1986
- 1986-03-22 DE DE8686103974T patent/DE3666226D1/de not_active Expired
- 1986-03-22 EP EP86103974A patent/EP0197407B1/de not_active Expired
- 1986-03-22 AT AT86103974T patent/ATE47138T1/de not_active IP Right Cessation
- 1986-04-04 US US06/848,212 patent/US4705867A/en not_active Expired - Lifetime
- 1986-04-09 JP JP61080291A patent/JPS61236775A/ja active Granted
- 1986-04-09 DD DD86288945A patent/DD251750A5/de unknown
- 1986-04-09 FI FI861506A patent/FI861506A/fi not_active IP Right Cessation
- 1986-04-10 HU HU861516A patent/HUT40638A/hu unknown
- 1986-04-10 ES ES553850A patent/ES8703451A1/es not_active Expired
-
1987
- 1987-07-15 US US07/073,820 patent/US4800044A/en not_active Expired - Lifetime
- 1987-07-15 US US07/073,584 patent/US4966732A/en not_active Expired - Lifetime
- 1987-11-20 JP JP62292234A patent/JPS63183558A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
DE3512911A1 (de) | 1986-10-16 |
ES8703451A1 (es) | 1987-02-16 |
US4705867A (en) | 1987-11-10 |
US4966732A (en) | 1990-10-30 |
JPH0351702B2 (hu) | 1991-08-07 |
ES553850A0 (es) | 1987-02-16 |
FI861506A0 (fi) | 1986-04-09 |
JPH0348188B2 (hu) | 1991-07-23 |
JPS61236775A (ja) | 1986-10-22 |
ATE47138T1 (de) | 1989-10-15 |
DD251750A5 (de) | 1987-11-25 |
JPS63183558A (ja) | 1988-07-28 |
EP0197407A3 (en) | 1987-09-02 |
FI861506A (fi) | 1986-10-12 |
DE3666226D1 (en) | 1989-11-16 |
US4800044A (en) | 1989-01-24 |
EP0197407A2 (de) | 1986-10-15 |
EP0197407B1 (de) | 1989-10-11 |
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