JPH0323529B2 - - Google Patents

Info

Publication number
JPH0323529B2
JPH0323529B2 JP55500624A JP50062480A JPH0323529B2 JP H0323529 B2 JPH0323529 B2 JP H0323529B2 JP 55500624 A JP55500624 A JP 55500624A JP 50062480 A JP50062480 A JP 50062480A JP H0323529 B2 JPH0323529 B2 JP H0323529B2
Authority
JP
Japan
Prior art keywords
polymer
polyethylene oxide
release
active substance
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP55500624A
Other languages
English (en)
Japanese (ja)
Other versions
JPS56500253A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Mosutein Paueru Enburii
Niiru Bonetsuto Gurahamu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NAT RES DEV
Original Assignee
NAT RES DEV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NAT RES DEV filed Critical NAT RES DEV
Publication of JPS56500253A publication Critical patent/JPS56500253A/ja
Publication of JPH0323529B2 publication Critical patent/JPH0323529B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/4833—Polyethers containing oxyethylene units
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/65—Low-molecular-weight compounds having active hydrogen with high-molecular-weight compounds having active hydrogen
    • C08G18/66—Compounds of groups C08G18/42, C08G18/48, or C08G18/52
    • C08G18/6666—Compounds of group C08G18/48 or C08G18/52
    • C08G18/667—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38
    • C08G18/6674—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/3203
    • C08G18/6677—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/3203 having at least three hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2210/00—Compositions for preparing hydrogels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2250/00—Compositions for preparing crystalline polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Lubricants (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Structures Of Non-Positive Displacement Pumps (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fluid-Damping Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP55500624A 1979-03-21 1980-03-21 Expired - Lifetime JPH0323529B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7909853 1979-03-21

Publications (2)

Publication Number Publication Date
JPS56500253A JPS56500253A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1981-03-05
JPH0323529B2 true JPH0323529B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-03-29

Family

ID=10504015

Family Applications (2)

Application Number Title Priority Date Filing Date
JP55500624A Expired - Lifetime JPH0323529B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1979-03-21 1980-03-21
JP55500625A Expired - Lifetime JPH0323530B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1979-03-21 1980-03-21

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP55500625A Expired - Lifetime JPH0323530B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1979-03-21 1980-03-21

Country Status (11)

Country Link
US (2) US4931288A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (2) EP0016654B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (2) JPH0323529B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (2) ATE14979T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (2) AU537741B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE3071006D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (2) GB2047094B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HK (2) HK79785A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (2) NZ193221A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (2) WO1980001984A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (2) ZA801654B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (68)

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US5079009A (en) * 1979-03-21 1992-01-07 National Research Development Corporation Controlled release compositions including polyethylene oxide with urethane cross-linking
NZ197543A (en) * 1980-07-02 1984-12-14 Commw Scient Ind Res Org Controlled release compositions for inclusion in intraruminal devices
US4466936A (en) * 1981-02-03 1984-08-21 Bayer Aktiengesellschaft Production of molds using gel compositions with depot action based on a polyurethane matrix and relatively high molecular weight polyols
AU558611B2 (en) * 1981-02-03 1987-02-05 Bayer Aktiengesellschaft Polyurethane gel
GB2108517B (en) * 1981-06-12 1985-06-12 Nat Res Dev Hydrogels
DK171937B1 (da) * 1981-06-12 1997-08-18 British Tech Group Fremgangsmåde til fremstilling af partikelformige hydrogeler
ZA831186B (en) * 1982-03-22 1983-11-30 Upjohn Ltd Gelled pge2/triacetin solutions
US4443428A (en) * 1982-06-21 1984-04-17 Euroceltique, S.A. Extended action controlled release compositions
FR2539135B1 (fr) * 1983-01-11 1986-02-28 Essilor Int Hydrogels de polyurethane et procede de fabrication
GB2135881A (en) * 1983-03-02 1984-09-12 Erba Farmitalia Method and pharmaceutical compositions for inhibiting or reducing gastrointestinal side effects of non-steroidal anti-inflammatory drugs
EP0132690B1 (de) * 1983-07-21 1989-02-01 Troponwerke GmbH & Co. KG Antiphlogistika enthaltende thermoplastische Kunststoffe
GB8319766D0 (en) * 1983-07-22 1983-08-24 Graham N B Controlled release device
IL72041A (en) * 1984-06-05 1990-01-18 Elka Touitou Preparation for controlled release of iodine
US5439966A (en) * 1984-07-12 1995-08-08 National Research Development Corporation Polyethylene oxide temperature - or fluid-sensitive shape memory device
FR2582944B1 (fr) * 1985-06-11 1990-10-26 Commissariat Energie Atomique Piece en polymere, notamment en polyurethane de polyoxyethylene a gonflement anisotrope, son procede de fabrication et son utilisation comme dilatateur du col uterin
EP0347145A3 (en) * 1988-06-14 1990-10-24 University Of Utah Research Foundation Heterogeneous interpenetrating polymer networks for the controlled release of drugs
US5342624A (en) * 1989-02-16 1994-08-30 British Technology Group Ltd. Dispensing device
DE69014404T2 (de) * 1989-03-17 1995-05-18 Ono Pharmaceutical Co Biologisch abbaubare Polyurethane.
US5225514A (en) * 1989-03-17 1993-07-06 Ono Pharmaceutical Co., Ltd. Azo containing polyurethanes for drug delivery to the large intestines
GB8918589D0 (en) * 1989-08-15 1989-09-27 Graham Neil B Polymeric compositions
US5833665A (en) 1990-06-14 1998-11-10 Integra Lifesciences I, Ltd. Polyurethane-biopolymer composite
ES2084825T3 (es) * 1990-07-26 1996-05-16 Monsanto Co Procedimiento de preparacion de poliamidas entrecruzadas.
AU653771B2 (en) * 1991-01-03 1994-10-13 Alkermes Controlled Therapeutics, Inc. Stabilization of proteins by cationic biopolymers
GB2254002B (en) * 1991-01-16 1995-03-22 Controlled Therapeutics Retrievable pessary
GB9101502D0 (en) * 1991-01-23 1991-03-06 Controlled Therapeutics Sct Controlled release compositions
US5273742A (en) * 1991-12-30 1993-12-28 Tyndale Plains-Hunter Ltd. Biomedical water soluble hydrophilic polyurethane polymers and method of use thereof
GB9313017D0 (en) * 1993-06-24 1993-08-11 Univ Strathclyde Measurement of water content
US5458879A (en) * 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
US6322815B1 (en) 1994-07-22 2001-11-27 W. Mark Saltzman Multipart drug delivery system
GB9418483D0 (en) * 1994-09-14 1994-11-02 British Tech Group Compound for use in pre-term labour
GB2306325B (en) * 1994-11-25 1997-09-10 William Leslie Porter Bolus for supplying biologically beneficial substances to ruminant animals
GB9506946D0 (en) * 1995-04-04 1995-05-24 Univ Strathclyde Microgels
US20020064546A1 (en) * 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
US6258351B1 (en) * 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
DE19734538C1 (de) * 1997-07-30 1998-12-24 Jenapharm Gmbh Bioadhäsive Tablette
ES2211033T3 (es) 1998-01-07 2004-07-01 Debio Recherche Pharmaceutique S.A. Acrilatos de polietilenglicol heterobifuncionales degradables y geles y conjugados derivados de dichos acrilatos.
US6514534B1 (en) * 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
GB9826192D0 (en) 1998-12-01 1999-01-20 Controlled Theraputics Scotlan Oral transmucosal delivery
TWI246524B (en) 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
US7265186B2 (en) * 2001-01-19 2007-09-04 Nektar Therapeutics Al, Corporation Multi-arm block copolymers as drug delivery vehicles
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
WO2004060967A1 (en) * 2002-12-31 2004-07-22 Nektar Therapeutics Al, Corporation Methods for the formation of hydrogels using thiosulfonate compositions and uses thereof
EP1644473B1 (en) 2003-06-03 2014-01-15 Cantimer Incorporated Phase change sensor
US20040259744A1 (en) * 2003-12-19 2004-12-23 Meidong Yang Skin and hair cleansers containing sulfur
US7282584B2 (en) * 2004-06-16 2007-10-16 Straumann Holding Ag Methylene blue
ATE385423T1 (de) * 2004-06-16 2008-02-15 Straumann Holding Ag Abdeckmembran
GB0417401D0 (en) * 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
WO2006133048A2 (en) * 2005-06-03 2006-12-14 Duramed Pharmaceuticals, Inc. Pharmaceutical compositions comprising prostanoid-receptor agonists and methods of making and using the same
US8568705B2 (en) 2005-07-18 2013-10-29 Nektar Therapeutics Method for preparing branched functionalized polymers using branched polyol cores
DE102005053066A1 (de) * 2005-11-04 2007-05-10 Basf Ag Verwendung von Copolymeren als Solubilisatoren für in Wasser schwerlöslichen Verbindungen
JP2009523119A (ja) * 2005-12-09 2009-06-18 ビーエーエスエフ ソシエタス・ヨーロピア 水に溶けにくい化合物のための可溶化剤としてのポリビニルラクタム−ポリオキシアルキレンブロックコポリマーの使用
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
RU2444364C2 (ru) * 2006-07-12 2012-03-10 Контроллд Терапьютикс (Скотлэнд) Лтд. Полимер для доставки лекарств с гидрохлоридной солью клиндамицина
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
JP2010534730A (ja) * 2007-07-26 2010-11-11 ビーエーエスエフ ソシエタス・ヨーロピア 溶液中でのグラフト重合により得られる、ポリエーテルに基づく固体形態のコポリマーの調製方法
US20110045076A1 (en) 2008-01-25 2011-02-24 Kiser Patrick F Linear order release polymer
DE102009052948B4 (de) * 2009-11-12 2013-05-29 Rkw Se Silageabdeckung
EP2701668A1 (en) 2011-04-29 2014-03-05 Massachusetts Institute of Technology Layer processing for pharmaceuticals
GB201110601D0 (en) 2011-06-23 2011-08-03 Controlled Therapeutics Scotland Ltd Improved bioresorbable
EP2754443A1 (en) 2013-01-09 2014-07-16 Ferring B.V. Misoprostol for the induction of labour
EP2689802A1 (en) 2012-07-26 2014-01-29 Ferring B.V. Misoprostol formulation
EP2689781A1 (en) 2012-07-26 2014-01-29 Ferring B.V. Misoprostol composition
EP2754442A1 (en) 2013-01-09 2014-07-16 Ferring B.V. Misoprostol for the induction of labour
EA031594B1 (ru) 2012-07-26 2019-01-31 Ферринг Б.В. Способ уменьшения дородового применения окситоцина и применение внутривлагалищного вкладыша по указанному назначению
US20150238414A1 (en) 2012-07-26 2015-08-27 Ferring B.V. Misoprostol Formulation
WO2015179461A1 (en) 2014-05-20 2015-11-26 Massachusetts Institute Of Technology Plasticity induced bonding
GB201916808D0 (en) 2019-11-19 2020-01-01 Ferring Bv Pharmaceutical delivery device

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ES335314A1 (es) * 1966-01-06 1967-12-01 Ceskoslovenska Akademie Ved Mejoras introducidas en la preparacion de vehiculos insolubles de sustancias al menos parcialmente solubles, biologicamente activas.
US3822238A (en) * 1972-08-02 1974-07-02 Princeton Polymer Lab Hydrophilic polyurethane polymers
US3975350A (en) * 1972-08-02 1976-08-17 Princeton Polymer Laboratories, Incorporated Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles
US3953406A (en) * 1973-01-26 1976-04-27 California Institute Of Technology Water-insoluble, swellable polyurethanes
US3993551A (en) * 1973-09-10 1976-11-23 Union Carbide Corporation Process for cocrosslinking water soluble polymers and products thereof
FR2250793B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1973-11-09 1978-12-29 Commissariat Energie Atomique
GB1494814A (en) * 1976-07-14 1977-12-14 Sanyo Chemical Ind Ltd Agrochemical compositions
GB1551620A (en) * 1976-12-13 1979-08-30 Ici Ltd Delivery means for biologically active agents
SE431821B (sv) * 1979-01-29 1984-03-05 Perstorp Ab Lagringsstabilt, prostaglandininnehallande medicinskt preparat

Also Published As

Publication number Publication date
JPS56500253A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1981-03-05
ZA801654B (en) 1981-10-28
JPH0323530B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-03-29
ATE15444T1 (de) 1985-09-15
WO1980001985A1 (en) 1980-10-02
HK79785A (en) 1985-10-25
HK79885A (en) 1985-10-25
GB2047094A (en) 1980-11-26
ZA801659B (en) 1981-10-28
EP0016654B1 (en) 1985-09-11
AU5669180A (en) 1980-09-25
JPS56500254A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1981-03-05
ATE14979T1 (de) 1985-09-15
WO1980001984A1 (en) 1980-10-02
NZ193222A (en) 1984-08-24
AU5669080A (en) 1980-09-25
AU537740B2 (en) 1984-07-12
EP0016654A1 (en) 1980-10-01
NZ193221A (en) 1984-08-24
EP0016652A1 (en) 1980-10-01
DE3071006D1 (en) 1985-09-26
GB2047093B (en) 1983-12-07
US4894238A (en) 1990-01-16
DE3071070D1 (en) 1985-10-17
US4931288A (en) 1990-06-05
GB2047093A (en) 1980-11-26
AU537741B2 (en) 1984-07-12
GB2047094B (en) 1983-12-07
EP0016652B1 (en) 1985-08-21

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