ATE14979T1 - Zusammensetzung mit geregelter wirkstofffreigabe und verfahren zu ihrer herstellung. - Google Patents

Zusammensetzung mit geregelter wirkstofffreigabe und verfahren zu ihrer herstellung.

Info

Publication number
ATE14979T1
ATE14979T1 AT80300900T AT80300900T ATE14979T1 AT E14979 T1 ATE14979 T1 AT E14979T1 AT 80300900 T AT80300900 T AT 80300900T AT 80300900 T AT80300900 T AT 80300900T AT E14979 T1 ATE14979 T1 AT E14979T1
Authority
AT
Austria
Prior art keywords
controlled release
release composition
production
prostaglandin
residues
Prior art date
Application number
AT80300900T
Other languages
English (en)
Inventor
Mostyn Powell Embrey
Neil Bonnette Graham
Original Assignee
Nat Res Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Res Dev filed Critical Nat Res Dev
Application granted granted Critical
Publication of ATE14979T1 publication Critical patent/ATE14979T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/4833—Polyethers containing oxyethylene units
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/65—Low-molecular-weight compounds having active hydrogen with high-molecular-weight compounds having active hydrogen
    • C08G18/66—Compounds of groups C08G18/42, C08G18/48, or C08G18/52
    • C08G18/6666—Compounds of group C08G18/48 or C08G18/52
    • C08G18/667—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38
    • C08G18/6674—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/3203
    • C08G18/6677—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/3203 having at least three hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2210/00—Compositions for preparing hydrogels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2250/00—Compositions for preparing crystalline polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Lubricants (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT80300900T 1979-03-21 1980-03-21 Zusammensetzung mit geregelter wirkstofffreigabe und verfahren zu ihrer herstellung. ATE14979T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7909853 1979-03-21
EP80300900A EP0016652B1 (de) 1979-03-21 1980-03-21 Zusammensetzung mit geregelter Wirkstofffreigabe und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
ATE14979T1 true ATE14979T1 (de) 1985-09-15

Family

ID=10504015

Family Applications (2)

Application Number Title Priority Date Filing Date
AT80300904T ATE15444T1 (de) 1979-03-21 1980-03-21 Zusammensetzung zur geregelten freigabe eines prostaglandins und verfahren zu ihrer herstellung.
AT80300900T ATE14979T1 (de) 1979-03-21 1980-03-21 Zusammensetzung mit geregelter wirkstofffreigabe und verfahren zu ihrer herstellung.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT80300904T ATE15444T1 (de) 1979-03-21 1980-03-21 Zusammensetzung zur geregelten freigabe eines prostaglandins und verfahren zu ihrer herstellung.

Country Status (11)

Country Link
US (2) US4931288A (de)
EP (2) EP0016654B1 (de)
JP (2) JPH0323530B2 (de)
AT (2) ATE15444T1 (de)
AU (2) AU537741B2 (de)
DE (2) DE3071006D1 (de)
GB (2) GB2047094B (de)
HK (2) HK79885A (de)
NZ (2) NZ193222A (de)
WO (2) WO1980001985A1 (de)
ZA (2) ZA801659B (de)

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US4466936A (en) * 1981-02-03 1984-08-21 Bayer Aktiengesellschaft Production of molds using gel compositions with depot action based on a polyurethane matrix and relatively high molecular weight polyols
EP0067671B1 (de) * 1981-06-12 1989-11-15 National Research Development Corporation Hydrogele
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US4443428A (en) * 1982-06-21 1984-04-17 Euroceltique, S.A. Extended action controlled release compositions
FR2539135B1 (fr) * 1983-01-11 1986-02-28 Essilor Int Hydrogels de polyurethane et procede de fabrication
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DE3476550D1 (en) * 1983-07-21 1989-03-09 Troponwerke Gmbh & Co Kg Thermoplastics containing antiphlogistics
GB8319766D0 (en) * 1983-07-22 1983-08-24 Graham N B Controlled release device
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US5439966A (en) * 1984-07-12 1995-08-08 National Research Development Corporation Polyethylene oxide temperature - or fluid-sensitive shape memory device
FR2582944B1 (fr) * 1985-06-11 1990-10-26 Commissariat Energie Atomique Piece en polymere, notamment en polyurethane de polyoxyethylene a gonflement anisotrope, son procede de fabrication et son utilisation comme dilatateur du col uterin
EP0347145A3 (de) * 1988-06-14 1990-10-24 University Of Utah Research Foundation Heterogene interpenetrierende Polymernetzwerke zur gesteuerten Arzneistofffreisetzung
US5342624A (en) * 1989-02-16 1994-08-30 British Technology Group Ltd. Dispensing device
US5225514A (en) * 1989-03-17 1993-07-06 Ono Pharmaceutical Co., Ltd. Azo containing polyurethanes for drug delivery to the large intestines
DE69014404T2 (de) * 1989-03-17 1995-05-18 Ono Pharmaceutical Co Biologisch abbaubare Polyurethane.
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US5833665A (en) 1990-06-14 1998-11-10 Integra Lifesciences I, Ltd. Polyurethane-biopolymer composite
US5474767A (en) * 1990-07-26 1995-12-12 Monsanto Company Polyamines and method for preparation thereof
CA2099376A1 (en) * 1991-01-03 1992-07-04 Henry E. Auer Stabilization of proteins by cationic biopolymers
GB2254002B (en) * 1991-01-16 1995-03-22 Controlled Therapeutics Retrievable pessary
GB9101502D0 (en) * 1991-01-23 1991-03-06 Controlled Therapeutics Sct Controlled release compositions
US5273742A (en) * 1991-12-30 1993-12-28 Tyndale Plains-Hunter Ltd. Biomedical water soluble hydrophilic polyurethane polymers and method of use thereof
GB9313017D0 (en) * 1993-06-24 1993-08-11 Univ Strathclyde Measurement of water content
US5458879A (en) * 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
US6322815B1 (en) 1994-07-22 2001-11-27 W. Mark Saltzman Multipart drug delivery system
GB9418483D0 (en) * 1994-09-14 1994-11-02 British Tech Group Compound for use in pre-term labour
GB2306325B (en) * 1994-11-25 1997-09-10 William Leslie Porter Bolus for supplying biologically beneficial substances to ruminant animals
GB9506946D0 (en) * 1995-04-04 1995-05-24 Univ Strathclyde Microgels
US20020064546A1 (en) * 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
US6258351B1 (en) 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
DE19734538C1 (de) * 1997-07-30 1998-12-24 Jenapharm Gmbh Bioadhäsive Tablette
ES2211033T3 (es) 1998-01-07 2004-07-01 Debio Recherche Pharmaceutique S.A. Acrilatos de polietilenglicol heterobifuncionales degradables y geles y conjugados derivados de dichos acrilatos.
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
GB9826192D0 (en) 1998-12-01 1999-01-20 Controlled Theraputics Scotlan Oral transmucosal delivery
TWI246524B (en) 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
US7265186B2 (en) * 2001-01-19 2007-09-04 Nektar Therapeutics Al, Corporation Multi-arm block copolymers as drug delivery vehicles
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
ATE400602T1 (de) * 2002-12-31 2008-07-15 Nektar Therapeutics Al Corp Verfahren zur herstellung von hydrogelen aus thiosulfonat-zusammensetzungen und ihre verwendungen
JP4758342B2 (ja) 2003-06-03 2011-08-24 キャンティマー インコーポレイテッド 相変化センサー
US20040259744A1 (en) * 2003-12-19 2004-12-23 Meidong Yang Skin and hair cleansers containing sulfur
EP1609491B1 (de) * 2004-06-16 2008-02-06 Straumann Holding AG Abdeckmembran
US7282584B2 (en) * 2004-06-16 2007-10-16 Straumann Holding Ag Methylene blue
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
WO2006133048A2 (en) * 2005-06-03 2006-12-14 Duramed Pharmaceuticals, Inc. Pharmaceutical compositions comprising prostanoid-receptor agonists and methods of making and using the same
ATE524509T1 (de) * 2005-07-18 2011-09-15 Nektar Therapeutics Verzweigte funktionalisierte polymere unter verwendung von verzweigten polyolen als kernen
DE102005053066A1 (de) 2005-11-04 2007-05-10 Basf Ag Verwendung von Copolymeren als Solubilisatoren für in Wasser schwerlöslichen Verbindungen
JP2009523119A (ja) * 2005-12-09 2009-06-18 ビーエーエスエフ ソシエタス・ヨーロピア 水に溶けにくい化合物のための可溶化剤としてのポリビニルラクタム−ポリオキシアルキレンブロックコポリマーの使用
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GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
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GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
WO2009013202A1 (de) * 2007-07-26 2009-01-29 Basf Se Verfahren zur herstellung von durch pfropfpolymerisation in lösung erhaltenen copolymeren auf basis von polyethern in fester form
AU2009206328A1 (en) 2008-01-25 2009-07-30 The University Of Utah Research Foundation Linear order release polymer
DE102009052948B4 (de) * 2009-11-12 2013-05-29 Rkw Se Silageabdeckung
WO2012149326A1 (en) 2011-04-29 2012-11-01 Massachusetts Institute Of Technology Layer processing for pharmaceuticals
GB201110601D0 (en) 2011-06-23 2011-08-03 Controlled Therapeutics Scotland Ltd Improved bioresorbable
EP2754442A1 (de) 2013-01-09 2014-07-16 Ferring B.V. Misoprostol zur Geburtseinleitung
EP2877181A1 (de) 2012-07-26 2015-06-03 Ferring BV Misprostolzusammensetzung
EP2877182A1 (de) 2012-07-26 2015-06-03 Ferring B.V. Misoprostol-formulierung
EP2689781A1 (de) 2012-07-26 2014-01-29 Ferring B.V. Misoprostolzusammensetzung
EP2754443A1 (de) 2013-01-09 2014-07-16 Ferring B.V. Misoprostol zur Geburtseinleitung
EP2689802A1 (de) 2012-07-26 2014-01-29 Ferring B.V. Misoprostolformulierung
WO2015179461A1 (en) * 2014-05-20 2015-11-26 Massachusetts Institute Of Technology Plasticity induced bonding
GB201916808D0 (en) 2019-11-19 2020-01-01 Ferring Bv Pharmaceutical delivery device

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US3822238A (en) * 1972-08-02 1974-07-02 Princeton Polymer Lab Hydrophilic polyurethane polymers
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US3953406A (en) * 1973-01-26 1976-04-27 California Institute Of Technology Water-insoluble, swellable polyurethanes
US3993551A (en) * 1973-09-10 1976-11-23 Union Carbide Corporation Process for cocrosslinking water soluble polymers and products thereof
FR2250793B1 (de) * 1973-11-09 1978-12-29 Commissariat Energie Atomique
GB1494814A (en) * 1976-07-14 1977-12-14 Sanyo Chemical Ind Ltd Agrochemical compositions
GB1551620A (en) * 1976-12-13 1979-08-30 Ici Ltd Delivery means for biologically active agents
SE431821B (sv) * 1979-01-29 1984-03-05 Perstorp Ab Lagringsstabilt, prostaglandininnehallande medicinskt preparat

Also Published As

Publication number Publication date
NZ193221A (en) 1984-08-24
JPS56500254A (de) 1981-03-05
GB2047094B (en) 1983-12-07
HK79885A (en) 1985-10-25
AU5669180A (en) 1980-09-25
US4894238A (en) 1990-01-16
GB2047093B (en) 1983-12-07
WO1980001984A1 (en) 1980-10-02
NZ193222A (en) 1984-08-24
JPS56500253A (de) 1981-03-05
AU537741B2 (en) 1984-07-12
WO1980001985A1 (en) 1980-10-02
GB2047094A (en) 1980-11-26
ATE15444T1 (de) 1985-09-15
EP0016652A1 (de) 1980-10-01
ZA801659B (en) 1981-10-28
DE3071006D1 (en) 1985-09-26
EP0016652B1 (de) 1985-08-21
AU5669080A (en) 1980-09-25
DE3071070D1 (en) 1985-10-17
ZA801654B (en) 1981-10-28
JPH0323529B2 (de) 1991-03-29
EP0016654B1 (de) 1985-09-11
HK79785A (en) 1985-10-25
EP0016654A1 (de) 1980-10-01
US4931288A (en) 1990-06-05
GB2047093A (en) 1980-11-26
AU537740B2 (en) 1984-07-12
JPH0323530B2 (de) 1991-03-29

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