DE3071070D1 - Composition for the controlled release of a prostaglandine and process for its preparation - Google Patents

Composition for the controlled release of a prostaglandine and process for its preparation

Info

Publication number
DE3071070D1
DE3071070D1 DE8080300904T DE3071070T DE3071070D1 DE 3071070 D1 DE3071070 D1 DE 3071070D1 DE 8080300904 T DE8080300904 T DE 8080300904T DE 3071070 T DE3071070 T DE 3071070T DE 3071070 D1 DE3071070 D1 DE 3071070D1
Authority
DE
Germany
Prior art keywords
controlled release
composition
prostaglandine
preparation
prostaglandin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080300904T
Other languages
English (en)
Inventor
Mostyn Powell Embrey
Neil Bonnette Graham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BTG International Ltd
Original Assignee
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Development Corp UK filed Critical National Research Development Corp UK
Application granted granted Critical
Publication of DE3071070D1 publication Critical patent/DE3071070D1/de
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00Polymeric products of isocyanates or isothiocyanates
    • C08G18/06Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40High-molecular-weight compounds
    • C08G18/48Polyethers
    • C08G18/4833Polyethers containing oxyethylene units
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00Polymeric products of isocyanates or isothiocyanates
    • C08G18/06Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/65Low-molecular-weight compounds having active hydrogen with high-molecular-weight compounds having active hydrogen
    • C08G18/66Compounds of groups C08G18/42, C08G18/48, or C08G18/52
    • C08G18/6666Compounds of group C08G18/48 or C08G18/52
    • C08G18/667Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38
    • C08G18/6674Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/3203
    • C08G18/6677Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/3203 having at least three hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2210/00Compositions for preparing hydrogels
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2250/00Compositions for preparing crystalline polymers
DE8080300904T 1979-03-21 1980-03-21 Composition for the controlled release of a prostaglandine and process for its preparation Expired DE3071070D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7909853 1979-03-21

Publications (1)

Publication Number Publication Date
DE3071070D1 true DE3071070D1 (en) 1985-10-17

Family

ID=10504015

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8080300904T Expired DE3071070D1 (en) 1979-03-21 1980-03-21 Composition for the controlled release of a prostaglandine and process for its preparation
DE8080300900T Expired DE3071006D1 (en) 1979-03-21 1980-03-21 Composition for the controlled release of an active substance and process for its preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8080300900T Expired DE3071006D1 (en) 1979-03-21 1980-03-21 Composition for the controlled release of an active substance and process for its preparation

Country Status (11)

Country Link
US (2) US4931288A (de)
EP (2) EP0016652B1 (de)
JP (2) JPH0323530B2 (de)
AT (2) ATE14979T1 (de)
AU (2) AU537741B2 (de)
DE (2) DE3071070D1 (de)
GB (2) GB2047093B (de)
HK (2) HK79785A (de)
NZ (2) NZ193222A (de)
WO (2) WO1980001984A1 (de)
ZA (2) ZA801654B (de)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079009A (en) * 1979-03-21 1992-01-07 National Research Development Corporation Controlled release compositions including polyethylene oxide with urethane cross-linking
NZ197543A (en) * 1980-07-02 1984-12-14 Commw Scient Ind Res Org Controlled release compositions for inclusion in intraruminal devices
US4466936A (en) * 1981-02-03 1984-08-21 Bayer Aktiengesellschaft Production of molds using gel compositions with depot action based on a polyurethane matrix and relatively high molecular weight polyols
AU558611B2 (en) * 1981-02-03 1987-02-05 Bayer Aktiengesellschaft Polyurethane gel
GB2100269B (en) * 1981-06-12 1985-06-12 Nat Res Dev Preparation of particulate gels
DE3280021D1 (en) * 1981-06-12 1989-12-21 Nat Res Dev Hydrogels
ZA831186B (en) * 1982-03-22 1983-11-30 Upjohn Ltd Gelled pge2/triacetin solutions
US4443428A (en) * 1982-06-21 1984-04-17 Euroceltique, S.A. Extended action controlled release compositions
FR2539135B1 (fr) * 1983-01-11 1986-02-28 Essilor Int Hydrogels de polyurethane et procede de fabrication
GB2135881A (en) * 1983-03-02 1984-09-12 Erba Farmitalia Method and pharmaceutical compositions for inhibiting or reducing gastrointestinal side effects of non-steroidal anti-inflammatory drugs
ATE40561T1 (de) * 1983-07-21 1989-02-15 Troponwerke Gmbh & Co Kg Antiphlogistika enthaltende thermoplastische kunststoffe.
GB8319766D0 (en) * 1983-07-22 1983-08-24 Graham N B Controlled release device
IL72041A (en) * 1984-06-05 1990-01-18 Elka Touitou Preparation for controlled release of iodine
US5439966A (en) * 1984-07-12 1995-08-08 National Research Development Corporation Polyethylene oxide temperature - or fluid-sensitive shape memory device
FR2582944B1 (fr) * 1985-06-11 1990-10-26 Commissariat Energie Atomique Piece en polymere, notamment en polyurethane de polyoxyethylene a gonflement anisotrope, son procede de fabrication et son utilisation comme dilatateur du col uterin
EP0347145A3 (de) * 1988-06-14 1990-10-24 University Of Utah Research Foundation Heterogene interpenetrierende Polymernetzwerke zur gesteuerten Arzneistofffreisetzung
US5342624A (en) * 1989-02-16 1994-08-30 British Technology Group Ltd. Dispensing device
US5225514A (en) * 1989-03-17 1993-07-06 Ono Pharmaceutical Co., Ltd. Azo containing polyurethanes for drug delivery to the large intestines
DE69014404T2 (de) * 1989-03-17 1995-05-18 Ono Pharmaceutical Co Biologisch abbaubare Polyurethane.
GB8918589D0 (en) * 1989-08-15 1989-09-27 Graham Neil B Polymeric compositions
US5833665A (en) * 1990-06-14 1998-11-10 Integra Lifesciences I, Ltd. Polyurethane-biopolymer composite
EP0540580B1 (de) * 1990-07-26 1994-04-13 G.D. Searle & Co. Arzneimittel freisetzendes polymeres system
CA2099376A1 (en) * 1991-01-03 1992-07-04 Henry E. Auer Stabilization of proteins by cationic biopolymers
GB2254002B (en) * 1991-01-16 1995-03-22 Controlled Therapeutics Retrievable pessary
GB9101502D0 (en) * 1991-01-23 1991-03-06 Controlled Therapeutics Sct Controlled release compositions
US5273742A (en) * 1991-12-30 1993-12-28 Tyndale Plains-Hunter Ltd. Biomedical water soluble hydrophilic polyurethane polymers and method of use thereof
GB9313017D0 (en) * 1993-06-24 1993-08-11 Univ Strathclyde Measurement of water content
US5458879A (en) * 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
US6322815B1 (en) 1994-07-22 2001-11-27 W. Mark Saltzman Multipart drug delivery system
GB9418483D0 (en) * 1994-09-14 1994-11-02 British Tech Group Compound for use in pre-term labour
GB2295316B (en) * 1994-11-25 1997-09-10 William Leslie Porter Bolus for supplying biologically beneficial substances to ruminant animals
GB9506946D0 (en) * 1995-04-04 1995-05-24 Univ Strathclyde Microgels
US20020064546A1 (en) 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
US6258351B1 (en) * 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
DE19734538C1 (de) * 1997-07-30 1998-12-24 Jenapharm Gmbh Bioadhäsive Tablette
ES2211033T3 (es) * 1998-01-07 2004-07-01 Debio Recherche Pharmaceutique S.A. Acrilatos de polietilenglicol heterobifuncionales degradables y geles y conjugados derivados de dichos acrilatos.
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
GB9826192D0 (en) * 1998-12-01 1999-01-20 Controlled Theraputics Scotlan Oral transmucosal delivery
TWI246524B (en) * 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
US7265186B2 (en) * 2001-01-19 2007-09-04 Nektar Therapeutics Al, Corporation Multi-arm block copolymers as drug delivery vehicles
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
AU2003300140A1 (en) * 2002-12-31 2004-07-29 Nektar Therapeutics Al, Corporation Methods for the formation of hydrogels using thiosulfonate compositions and uses thereof
EP1644473B1 (de) 2003-06-03 2014-01-15 Cantimer Incorporated Phasenänderungssensor
US20040259744A1 (en) * 2003-12-19 2004-12-23 Meidong Yang Skin and hair cleansers containing sulfur
US7282584B2 (en) * 2004-06-16 2007-10-16 Straumann Holding Ag Methylene blue
EP1609491B1 (de) * 2004-06-16 2008-02-06 Straumann Holding AG Abdeckmembran
GB0417401D0 (en) * 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
US20060286172A1 (en) * 2005-06-03 2006-12-21 Anu Mahashabde Pharmaceutical compositions comprising prostanoid-receptor agonists and methods of making and using the same
US8568705B2 (en) * 2005-07-18 2013-10-29 Nektar Therapeutics Method for preparing branched functionalized polymers using branched polyol cores
DE102005053066A1 (de) * 2005-11-04 2007-05-10 Basf Ag Verwendung von Copolymeren als Solubilisatoren für in Wasser schwerlöslichen Verbindungen
US20080300320A1 (en) * 2005-12-09 2008-12-04 Basf Se Use of Polyvinyl Lactam-Polyalkylene Block Copolymers as Solubilisers for Poorly Water-Soluble Compounds
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
EP2037938A2 (de) * 2006-07-12 2009-03-25 Controlled Therapeutics (Scotland) Ltd. Arzneiabgabe-polymer mit clindamycin-hydrochloridsalz
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
CN101765616A (zh) * 2007-07-26 2010-06-30 巴斯夫欧洲公司 制备通过接枝聚合在溶液中获得的并基于固体聚醚的共聚物的方法
EP2244782A4 (de) 2008-01-25 2011-09-14 Univ Utah Res Found Polymer für lineare freisetzung
DE102009052948B4 (de) * 2009-11-12 2013-05-29 Rkw Se Silageabdeckung
WO2012149326A1 (en) 2011-04-29 2012-11-01 Massachusetts Institute Of Technology Layer processing for pharmaceuticals
GB201110601D0 (en) 2011-06-23 2011-08-03 Controlled Therapeutics Scotland Ltd Improved bioresorbable
CA2879772A1 (en) 2012-07-26 2014-01-30 Ferring B.V. Misprostol composition
AU2013294956B2 (en) 2012-07-26 2018-03-08 Ferring B.V. Misoprostol formulation
EP2689802A1 (de) 2012-07-26 2014-01-29 Ferring B.V. Misoprostolformulierung
EP2754442A1 (de) 2013-01-09 2014-07-16 Ferring B.V. Misoprostol zur Geburtseinleitung
EP2689781A1 (de) 2012-07-26 2014-01-29 Ferring B.V. Misoprostolzusammensetzung
EP2754443A1 (de) 2013-01-09 2014-07-16 Ferring B.V. Misoprostol zur Geburtseinleitung
WO2015179461A1 (en) 2014-05-20 2015-11-26 Massachusetts Institute Of Technology Plasticity induced bonding
GB201916808D0 (en) 2019-11-19 2020-01-01 Ferring Bv Pharmaceutical delivery device

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1586811A (de) * 1966-01-06 1970-03-06
US3822238A (en) * 1972-08-02 1974-07-02 Princeton Polymer Lab Hydrophilic polyurethane polymers
US3975350A (en) * 1972-08-02 1976-08-17 Princeton Polymer Laboratories, Incorporated Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles
US3953406A (en) * 1973-01-26 1976-04-27 California Institute Of Technology Water-insoluble, swellable polyurethanes
US3993551A (en) * 1973-09-10 1976-11-23 Union Carbide Corporation Process for cocrosslinking water soluble polymers and products thereof
FR2250793B1 (de) * 1973-11-09 1978-12-29 Commissariat Energie Atomique
GB1494814A (en) * 1976-07-14 1977-12-14 Sanyo Chemical Ind Ltd Agrochemical compositions
GB1551620A (en) * 1976-12-13 1979-08-30 Ici Ltd Delivery means for biologically active agents
SE431821B (sv) * 1979-01-29 1984-03-05 Perstorp Ab Lagringsstabilt, prostaglandininnehallande medicinskt preparat

Also Published As

Publication number Publication date
EP0016652B1 (de) 1985-08-21
ZA801654B (en) 1981-10-28
EP0016654A1 (de) 1980-10-01
HK79785A (en) 1985-10-25
ZA801659B (en) 1981-10-28
EP0016652A1 (de) 1980-10-01
US4931288A (en) 1990-06-05
JPS56500254A (de) 1981-03-05
WO1980001984A1 (en) 1980-10-02
GB2047094B (en) 1983-12-07
GB2047094A (en) 1980-11-26
JPH0323530B2 (de) 1991-03-29
NZ193221A (en) 1984-08-24
WO1980001985A1 (en) 1980-10-02
AU537740B2 (en) 1984-07-12
ATE14979T1 (de) 1985-09-15
GB2047093B (en) 1983-12-07
JPH0323529B2 (de) 1991-03-29
JPS56500253A (de) 1981-03-05
AU5669180A (en) 1980-09-25
AU5669080A (en) 1980-09-25
US4894238A (en) 1990-01-16
EP0016654B1 (de) 1985-09-11
GB2047093A (en) 1980-11-26
DE3071006D1 (en) 1985-09-26
HK79885A (en) 1985-10-25
ATE15444T1 (de) 1985-09-15
AU537741B2 (en) 1984-07-12
NZ193222A (en) 1984-08-24

Similar Documents

Publication Publication Date Title
DE3071070D1 (en) Composition for the controlled release of a prostaglandine and process for its preparation
GB2066268B (en) Ethylene polymer composition
AU536252B2 (en) Olefin polymerization catalyst composition
AU529762B2 (en) Olefin polymerization catalyst compositions
DE3265687D1 (en) Gel compounds containing, where appropriate, active ingredients based on polyurethane matrices and high molecular weight polyols, process for their manufacture as well as their use
DE2861668D1 (en) Process for the preparation of linear, high molecular polyesters
EP0274721A3 (en) Polymers containing amino groups, their manufacture and their use
DE3064357D1 (en) Cross-linkable composition of a polyethylene and isobutylene copolymer, process for manufacturing cross-linked articles and articles from the composition
GB2021125B (en) Biosynthetic polymeric compositions
JPS54126253A (en) Preparation for ethylene copolymer composition
AU5429880A (en) Catalyst compositions for polysiloxane modification
ES2006079A6 (es) Un procedimiento de preparacion de polimeros yodados.
AU538706B2 (en) Peroxide polymerisation catalyst composition
DE3069334D1 (en) Ziegler-type catalyst composition
AU583065B2 (en) Process for preparing low molecular weight isobutylene polymers
GB2063279B (en) Thermoplastic elastomers based on aliphatic copolyetheresteramide blocks of high molecular weight
DE3066589D1 (en) Emulsifier for preparing polymers
DE3361052D1 (en) Process for preparing block copolymers based on ethylene polymers and other polymers
JPS5676454A (en) High molecular composition
AU534822B2 (en) Ethylene copolymer composition
DE2965794D1 (en) 2,4,6-triketohexahydrotriazines containing isocyanate groups and a process for their preparation
JPS51138786A (en) Method for manufacturing polyethylene
CA888777A (en) Polyethylene compositions containing n,n,n' trialiphatic-n'-aryl-p-phenylenediamines as antioxidants
JPS52117399A (en) Polyurethane elastomers containing isocyanurate rings, their preparati on and filled tires using them
CS711379A1 (en) Zpusob vyroby 6 substituovanych n l 5r,8s,10r p 8 ergolinyl p n,n diethylmocovin

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BRITISH TECHNOLOGY GROUP LTD., LONDON, GB

8328 Change in the person/name/address of the agent

Free format text: DEUFEL, P., DIPL.-WIRTSCH.-ING.DR.RER.NAT. HERTEL, W., DIPL.-PHYS. RUTETZKI, A., DIPL.-ING.UNIV. RUCKER, E., DIPL.-CHEM. UNIV. DR.RER.NAT. HUBER, B., DIPL.-BIOL. DR.RER.NAT. BECKER, E., DR.RER.NAT., 80331 MUENCHEN KURIG, T., DIPL.-PHYS., 83022 ROSENHEIM STEIL, C., DIPL.-ING., PAT.-ANWAELTE, 80331 MUENCHEN