JPH03174349A

JPH03174349A - 水硬性リン酸カルシウムセメント

水硬性リン酸カルシウムセメント

Info

Publication number: JPH03174349A
Authority: JP; Japan
Prior art keywords: calcium phosphate; cement; phosphate; calcium; hydraulic
Prior art date: 1989-12-01
Legal status : Granted

Application number

JP1310544A

Other languages

English (en)

Japanese (ja)

Other versions

JPH0528629B2 (enrdf_load_stackoverflow

Inventor

Masahiro Hirano

昌弘平野

Hiroyasu Takeuchi

啓泰竹内

Current Assignee

Mitsubishi Materials Corp

Original Assignee

Mitsubishi Materials Corp

Priority date

1989-12-01

Filing date

1989-12-01

Publication date

1991-07-29

1989-12-01 Application filed by Mitsubishi Materials Corp filed Critical Mitsubishi Materials Corp

1989-12-01 Priority to JP1310544A priority Critical patent/JPH03174349A/ja

1991-07-29 Publication of JPH03174349A publication Critical patent/JPH03174349A/ja

1993-04-26 Publication of JPH0528629B2 publication Critical patent/JPH0528629B2/ja

Status Granted legal-status Critical Current

Links

229910000389 calcium phosphate Inorganic materials 0.000 title claims abstract description 55
239000001506 calcium phosphate Substances 0.000 title claims abstract description 47
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title claims abstract description 47
235000011010 calcium phosphates Nutrition 0.000 title claims abstract description 46
239000004568 cement Substances 0.000 title claims abstract description 43
OKJPEAGHQZHRQV-UHFFFAOYSA-N iodoform Chemical compound IC(I)I OKJPEAGHQZHRQV-UHFFFAOYSA-N 0.000 claims abstract description 16
239000000203 mixture Substances 0.000 claims abstract description 16
YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 claims abstract description 11
TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims abstract description 10
229940036348 bismuth carbonate Drugs 0.000 claims abstract description 4
GMZOPRQQINFLPQ-UHFFFAOYSA-H dibismuth;tricarbonate Chemical compound [Bi+3].[Bi+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O GMZOPRQQINFLPQ-UHFFFAOYSA-H 0.000 claims abstract description 4
235000019691 monocalcium phosphate Nutrition 0.000 claims description 10
150000001875 compounds Chemical class 0.000 claims description 4
239000011812 mixed powder Substances 0.000 claims description 2
239000011575 calcium Substances 0.000 abstract description 12
229910052791 calcium Inorganic materials 0.000 abstract description 6
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 5
239000002872 contrast media Substances 0.000 abstract description 4
239000003479 dental cement Substances 0.000 abstract description 2
229910000150 monocalcium phosphate Inorganic materials 0.000 abstract description 2
239000002245 particle Substances 0.000 abstract description 2
229910019142 PO4 Inorganic materials 0.000 abstract 4
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 4
239000010452 phosphate Substances 0.000 abstract 4
PUAQLLVFLMYYJJ-UHFFFAOYSA-N 2-aminopropiophenone Chemical compound CC(N)C(=O)C1=CC=CC=C1 PUAQLLVFLMYYJJ-UHFFFAOYSA-N 0.000 abstract 2
229910014771 Ca4(PO4)2O Inorganic materials 0.000 abstract 1
239000004599 antimicrobial Substances 0.000 abstract 1
239000007788 liquid Substances 0.000 description 11
239000000843 powder Substances 0.000 description 9
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
210000000988 bone and bone Anatomy 0.000 description 7
229920001282 polysaccharide Polymers 0.000 description 7
239000005017 polysaccharide Substances 0.000 description 7
150000004804 polysaccharides Chemical class 0.000 description 7
239000000243 solution Substances 0.000 description 7
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
239000007864 aqueous solution Substances 0.000 description 5
150000003839 salts Chemical class 0.000 description 5
SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 4
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
229920001661 Chitosan Polymers 0.000 description 4
229920001287 Chondroitin sulfate Polymers 0.000 description 4
230000000844 anti-bacterial effect Effects 0.000 description 4
229940059329 chondroitin sulfate Drugs 0.000 description 4
238000002156 mixing Methods 0.000 description 4
239000000126 substance Substances 0.000 description 4
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 3
241000894006 Bacteria Species 0.000 description 3
229920002101 Chitin Polymers 0.000 description 3
229920002527 Glycogen Polymers 0.000 description 3
229920000084 Gum arabic Polymers 0.000 description 3
241000978776 Senegalia senegal Species 0.000 description 3
229920002472 Starch Polymers 0.000 description 3
239000000205 acacia gum Substances 0.000 description 3
235000010489 acacia gum Nutrition 0.000 description 3
235000010443 alginic acid Nutrition 0.000 description 3
239000000783 alginic acid Substances 0.000 description 3
229920000615 alginic acid Polymers 0.000 description 3
229960001126 alginic acid Drugs 0.000 description 3
150000004781 alginic acids Chemical class 0.000 description 3
239000003242 anti bacterial agent Substances 0.000 description 3
235000019700 dicalcium phosphate Nutrition 0.000 description 3
-1 glycerin Chemical compound 0.000 description 3
229940096919 glycogen Drugs 0.000 description 3
229920002674 hyaluronan Polymers 0.000 description 3
229960003160 hyaluronic acid Drugs 0.000 description 3
229910052588 hydroxylapatite Inorganic materials 0.000 description 3
230000007794 irritation Effects 0.000 description 3
238000004898 kneading Methods 0.000 description 3
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 3
239000008107 starch Substances 0.000 description 3
235000019698 starch Nutrition 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
239000002253 acid Substances 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
238000001354 calcination Methods 0.000 description 2
229910000019 calcium carbonate Inorganic materials 0.000 description 2
JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 2
FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 2
XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 description 2
229940043256 calcium pyrophosphate Drugs 0.000 description 2
239000000919 ceramic Substances 0.000 description 2
230000007423 decrease Effects 0.000 description 2
210000004262 dental pulp cavity Anatomy 0.000 description 2
235000019821 dicalcium diphosphate Nutrition 0.000 description 2
238000010304 firing Methods 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
239000000463 material Substances 0.000 description 2
GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 description 2
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
241001474374 Blennius Species 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
241000238424 Crustacea Species 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
241000238631 Hexapoda Species 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
229920002385 Sodium hyaluronate Polymers 0.000 description 1
239000003929 acidic solution Substances 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
239000003463 adsorbent Substances 0.000 description 1
239000008272 agar Substances 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
229910052797 bismuth Inorganic materials 0.000 description 1
JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
159000000007 calcium salts Chemical class 0.000 description 1
150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
229960003260 chlorhexidine Drugs 0.000 description 1
KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 description 1
235000015165 citric acid Nutrition 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000007547 defect Effects 0.000 description 1
229940095079 dicalcium phosphate anhydrous Drugs 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000010828 elution Methods 0.000 description 1
229910052587 fluorapatite Inorganic materials 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
230000009036 growth inhibition Effects 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
229910001410 inorganic ion Inorganic materials 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
239000002609 medium Substances 0.000 description 1
238000000034 method Methods 0.000 description 1
150000004682 monohydrates Chemical class 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
239000002631 root canal filling material Substances 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
229940010747 sodium hyaluronate Drugs 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000012137 tryptone Substances 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1