JPH0312077B2 - - Google Patents

Info

Publication number
JPH0312077B2
JPH0312077B2 JP57208363A JP20836382A JPH0312077B2 JP H0312077 B2 JPH0312077 B2 JP H0312077B2 JP 57208363 A JP57208363 A JP 57208363A JP 20836382 A JP20836382 A JP 20836382A JP H0312077 B2 JPH0312077 B2 JP H0312077B2
Authority
JP
Japan
Prior art keywords
fluoroerythromycin
compound
carried out
oxide
reduction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP57208363A
Other languages
English (en)
Japanese (ja)
Other versions
JPS58109496A (ja
Inventor
Tosukano Ruchiaano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PIEERERU SpA
Original Assignee
PIEERERU SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PIEERERU SpA filed Critical PIEERERU SpA
Publication of JPS58109496A publication Critical patent/JPS58109496A/ja
Publication of JPH0312077B2 publication Critical patent/JPH0312077B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP57208363A 1981-11-27 1982-11-27 マクロライド抗生物質の合成の化学的方法 Granted JPS58109496A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT25345A/81 1981-11-27
IT25345/81A IT1195299B (it) 1981-11-27 1981-11-27 Procedimento chimico di sintesi per la preparazione di antibiotici macrolidici

Publications (2)

Publication Number Publication Date
JPS58109496A JPS58109496A (ja) 1983-06-29
JPH0312077B2 true JPH0312077B2 (en, 2012) 1991-02-19

Family

ID=11216419

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57208363A Granted JPS58109496A (ja) 1981-11-27 1982-11-27 マクロライド抗生物質の合成の化学的方法

Country Status (13)

Country Link
US (1) US4514562A (en, 2012)
EP (1) EP0080763B1 (en, 2012)
JP (1) JPS58109496A (en, 2012)
KR (1) KR880001566B1 (en, 2012)
AT (1) ATE15805T1 (en, 2012)
BE (1) BE895155A (en, 2012)
CA (1) CA1209987A (en, 2012)
CH (1) CH660596A5 (en, 2012)
DE (1) DE3266578D1 (en, 2012)
FI (1) FI75835C (en, 2012)
FR (1) FR2517311B1 (en, 2012)
IT (1) IT1195299B (en, 2012)
PH (1) PH18391A (en, 2012)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1163796B (it) * 1983-07-18 1987-04-08 Pierrel Spa Procedimento per la preparazione di (8s)-8-fluoroeritromicina
IT1196041B (it) * 1984-03-08 1988-11-10 Pierrel Spa Emichetali di (8s)-8-fluoroeritromicine,il procedimento per la loro preparazione e le formulazioni adatte alla somministrazione orale che contengono i prodotti
DE3424525A1 (de) * 1984-07-04 1986-01-16 Kernforschungsanlage Jülich GmbH, 5170 Jülich Verfahren zur herstellung von (pfeil hoch)1(pfeil hoch)(pfeil hoch)8(pfeil hoch)f-alkyl- und arylverbindungen durch halogenaustausch
JPS6185378A (ja) * 1984-10-02 1986-04-30 Daikin Ind Ltd ８−フルオロエリスロノライド誘導体の製法
US4876245A (en) * 1986-12-22 1989-10-24 Daikin Industries Ltd. Fluorine-containing macrolide compounds and their use
MA21697A1 (fr) * 1988-12-19 1990-07-01 Dow Agrosciences Llc Composes de macrolides.
US5591606A (en) * 1992-11-06 1997-01-07 Dowelanco Process for the production of A83543 compounds with Saccharopolyspora spinosa
JP4258575B2 (ja) * 1993-03-12 2009-04-30 ダウ・アグロサイエンス・エル・エル・シー 新規ａ８３５４３化合物及びそれらの製造法
US5393743A (en) * 1993-07-06 1995-02-28 Abbott Laboratories Erythromycin derivatives
US5552533A (en) * 1994-09-14 1996-09-03 Alliedsignal Inc. Preparation of (8S)-8-fluoroerythromycins with N-F fluorinating agents
US6001981A (en) * 1996-06-13 1999-12-14 Dow Agrosciences Llc Synthetic modification of Spinosyn compounds
WO2005082996A1 (fr) * 2004-02-24 2005-09-09 Arkema France Composition reticulee comprenant un copolymere sequence triblocs, son procede d'obtention et ses utilisations
WO2011080739A2 (en) 2009-12-29 2011-07-07 Yeda Research And Development Co. Ltd. Synergistic antibiotic combinations and derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2812323A (en) * 1954-11-03 1957-11-05 Lilly Co Eli Des-n-methyl erythromycin
US3674773A (en) * 1970-10-06 1972-07-04 Abbott Lab Erythromycin derivatives
FI72346C (fi) * 1981-01-09 1987-05-11 Pierrel Spa Saett att framstaella nya halvsyntetiska makrolidantibiotika.

Also Published As

Publication number Publication date
CH660596A5 (it) 1987-05-15
US4514562A (en) 1985-04-30
CA1209987A (en) 1986-08-19
DE3266578D1 (en) 1985-10-31
FR2517311B1 (fr) 1987-12-24
FI75835C (fi) 1988-08-08
FR2517311A1 (fr) 1983-06-03
KR840002413A (ko) 1984-07-02
BE895155A (fr) 1983-03-16
EP0080763A1 (en) 1983-06-08
FI75835B (fi) 1988-04-29
KR880001566B1 (ko) 1988-08-22
ATE15805T1 (de) 1985-10-15
PH18391A (en) 1985-06-21
EP0080763B1 (en) 1985-09-25
IT1195299B (it) 1988-10-12
IT8125345A0 (it) 1981-11-27
FI824084L (fi) 1983-05-28
JPS58109496A (ja) 1983-06-29
FI824084A0 (fi) 1982-11-26

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