ATE15805T1 - Chemisches verfahren zur herstellung makrolider antibiotika. - Google Patents

Chemisches verfahren zur herstellung makrolider antibiotika.

Info

Publication number
ATE15805T1
ATE15805T1 AT82201476T AT82201476T ATE15805T1 AT E15805 T1 ATE15805 T1 AT E15805T1 AT 82201476 T AT82201476 T AT 82201476T AT 82201476 T AT82201476 T AT 82201476T AT E15805 T1 ATE15805 T1 AT E15805T1
Authority
AT
Austria
Prior art keywords
macrolider
antibiotics
manufacture
chemical process
fluoroerythomycins
Prior art date
Application number
AT82201476T
Other languages
English (en)
Inventor
Luciano Toscano
Original Assignee
Pierrel Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel Spa filed Critical Pierrel Spa
Application granted granted Critical
Publication of ATE15805T1 publication Critical patent/ATE15805T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT82201476T 1981-11-27 1982-11-19 Chemisches verfahren zur herstellung makrolider antibiotika. ATE15805T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT25345/81A IT1195299B (it) 1981-11-27 1981-11-27 Procedimento chimico di sintesi per la preparazione di antibiotici macrolidici
EP82201476A EP0080763B1 (de) 1981-11-27 1982-11-19 Chemisches Verfahren zur Herstellung makrolider Antibiotika

Publications (1)

Publication Number Publication Date
ATE15805T1 true ATE15805T1 (de) 1985-10-15

Family

ID=11216419

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82201476T ATE15805T1 (de) 1981-11-27 1982-11-19 Chemisches verfahren zur herstellung makrolider antibiotika.

Country Status (13)

Country Link
US (1) US4514562A (de)
EP (1) EP0080763B1 (de)
JP (1) JPS58109496A (de)
KR (1) KR880001566B1 (de)
AT (1) ATE15805T1 (de)
BE (1) BE895155A (de)
CA (1) CA1209987A (de)
CH (1) CH660596A5 (de)
DE (1) DE3266578D1 (de)
FI (1) FI75835C (de)
FR (1) FR2517311B1 (de)
IT (1) IT1195299B (de)
PH (1) PH18391A (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1163796B (it) * 1983-07-18 1987-04-08 Pierrel Spa Procedimento per la preparazione di (8s)-8-fluoroeritromicina
IT1196041B (it) * 1984-03-08 1988-11-10 Pierrel Spa Emichetali di (8s)-8-fluoroeritromicine,il procedimento per la loro preparazione e le formulazioni adatte alla somministrazione orale che contengono i prodotti
DE3424525A1 (de) * 1984-07-04 1986-01-16 Kernforschungsanlage Jülich GmbH, 5170 Jülich Verfahren zur herstellung von (pfeil hoch)1(pfeil hoch)(pfeil hoch)8(pfeil hoch)f-alkyl- und arylverbindungen durch halogenaustausch
JPS6185378A (ja) * 1984-10-02 1986-04-30 Daikin Ind Ltd ８−フルオロエリスロノライド誘導体の製法
US4876245A (en) * 1986-12-22 1989-10-24 Daikin Industries Ltd. Fluorine-containing macrolide compounds and their use
MA21697A1 (fr) * 1988-12-19 1990-07-01 Dow Agrosciences Llc Composes de macrolides.
US5591606A (en) * 1992-11-06 1997-01-07 Dowelanco Process for the production of A83543 compounds with Saccharopolyspora spinosa
CA2156194C (en) * 1993-03-12 2008-01-08 Jon S. Mynderse New a83543 compounds and process for production thereof
US5393743A (en) * 1993-07-06 1995-02-28 Abbott Laboratories Erythromycin derivatives
US5552533A (en) * 1994-09-14 1996-09-03 Alliedsignal Inc. Preparation of (8S)-8-fluoroerythromycins with N-F fluorinating agents
US6001981A (en) * 1996-06-13 1999-12-14 Dow Agrosciences Llc Synthetic modification of Spinosyn compounds
KR20070012643A (ko) * 2004-02-24 2007-01-26 아르끄마 프랑스 삼블록 연속 공중합체를 포함하는 가교 조성물, 그의 제조방법 및 그의 용도
WO2011080739A2 (en) 2009-12-29 2011-07-07 Yeda Research And Development Co. Ltd. Synergistic antibiotic combinations and derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2812323A (en) * 1954-11-03 1957-11-05 Lilly Co Eli Des-n-methyl erythromycin
US3674773A (en) * 1970-10-06 1972-07-04 Abbott Lab Erythromycin derivatives
FI72346C (fi) * 1981-01-09 1987-05-11 Pierrel Spa Saett att framstaella nya halvsyntetiska makrolidantibiotika.

Also Published As

Publication number Publication date
IT8125345A0 (it) 1981-11-27
PH18391A (en) 1985-06-21
CA1209987A (en) 1986-08-19
FI824084L (fi) 1983-05-28
DE3266578D1 (en) 1985-10-31
EP0080763B1 (de) 1985-09-25
EP0080763A1 (de) 1983-06-08
BE895155A (fr) 1983-03-16
FI75835C (fi) 1988-08-08
JPH0312077B2 (de) 1991-02-19
KR840002413A (ko) 1984-07-02
US4514562A (en) 1985-04-30
KR880001566B1 (ko) 1988-08-22
FI824084A0 (fi) 1982-11-26
CH660596A5 (it) 1987-05-15
FR2517311A1 (fr) 1983-06-03
FR2517311B1 (fr) 1987-12-24
IT1195299B (it) 1988-10-12
FI75835B (fi) 1988-04-29
JPS58109496A (ja) 1983-06-29

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time