JPH026513B2 - - Google Patents

Info

Publication number
JPH026513B2
JPH026513B2 JP59501243A JP50124384A JPH026513B2 JP H026513 B2 JPH026513 B2 JP H026513B2 JP 59501243 A JP59501243 A JP 59501243A JP 50124384 A JP50124384 A JP 50124384A JP H026513 B2 JPH026513 B2 JP H026513B2
Authority
JP
Japan
Prior art keywords
urokinase
fibrinogen
derivatives
enzyme
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP59501243A
Other languages
English (en)
Japanese (ja)
Other versions
JPS60501239A (ja
Inventor
Arekusandoru Bashiriebichi Makishimenko
Erena Georugiebuna Teichenko
Urajimiiru Petorobichi Toruchirin
Urajimiiru Nikoraebichi Sumirunofu
Ebugenii Iwanobichi Chazofu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FUSESO KARUDEIOROGICHESUKII NAUCHINO TSUENTORU A MEDEITSUINSUKIFU N SSSR
Original Assignee
FUSESO KARUDEIOROGICHESUKII NAUCHINO TSUENTORU A MEDEITSUINSUKIFU N SSSR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FUSESO KARUDEIOROGICHESUKII NAUCHINO TSUENTORU A MEDEITSUINSUKIFU N SSSR filed Critical FUSESO KARUDEIOROGICHESUKII NAUCHINO TSUENTORU A MEDEITSUINSUKIFU N SSSR
Publication of JPS60501239A publication Critical patent/JPS60501239A/ja
Publication of JPH026513B2 publication Critical patent/JPH026513B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP59501243A 1983-05-10 1984-03-01 ウロキナ−ゼ誘導体 Granted JPS60501239A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SU3590957/28 1983-05-10
SU833590957A SU1128601A1 (ru) 1983-05-10 1983-05-10 Урокиназа,иммобилизированна на фибриногене

Publications (2)

Publication Number Publication Date
JPS60501239A JPS60501239A (ja) 1985-08-08
JPH026513B2 true JPH026513B2 (en, 2012) 1990-02-09

Family

ID=21063322

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59501243A Granted JPS60501239A (ja) 1983-05-10 1984-03-01 ウロキナ−ゼ誘導体

Country Status (8)

Country Link
US (1) US4564596A (en, 2012)
JP (1) JPS60501239A (en, 2012)
DE (1) DE3490222T1 (en, 2012)
GB (1) GB2150576B (en, 2012)
IT (1) IT1199522B (en, 2012)
SE (1) SE442022B (en, 2012)
SU (1) SU1128601A1 (en, 2012)
WO (1) WO1984004536A1 (en, 2012)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8400653D0 (en) * 1984-01-11 1984-02-15 Beecham Group Plc Conjugates
US4783330A (en) * 1984-11-15 1988-11-08 New England Medical Center Hospitals, Inc. Monoclonal antibodies to activated platelets
CA1335361C (en) * 1989-05-24 1995-04-25 Andrei Z. Budzynski Thrombus-targeted complexes of plasminogen activator and fibrin fragments
US5632986A (en) * 1991-05-09 1997-05-27 The University Of Washington Phospholipid-targeted thrombolytic agents
CA2091544A1 (en) * 1992-03-26 1993-09-27 Shing F. Kwan Stabilization of functional proteins
US10127295B2 (en) * 2009-06-05 2018-11-13 Microsoft Technolofy Licensing, Llc Geographic co-location service for cloud computing
US8577892B2 (en) * 2009-06-05 2013-11-05 Microsoft Corporation Utilizing affinity groups to allocate data items and computing resources
RU2674032C1 (ru) * 2018-06-05 2018-12-04 федеральное государственное автономное образовательное учреждение высшего образования "Санкт-Петербургский национальный исследовательский университет информационных технологий, механики и оптики" (Университет ИТМО) Способ получения урокиназы, энтрапированной в коллоидный магнитный керамический нанокомпозитный материал

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3544427A (en) * 1968-04-18 1970-12-01 Century Lab Inc Method of production of urokinase
US4029767A (en) * 1971-09-24 1977-06-14 Choay S.A. Pharmaceutical compositions of stable urokinase-heparin complexes and methods for use thereof
DE2431342C3 (de) * 1973-07-27 1978-10-26 Behringwerke Ag, 3550 Marburg Verfahren zur Messung des Plasminogengehaltes durch Bestimmung der Bildung von Fibrin in einer Probe
JPS6043116B2 (ja) * 1978-02-21 1985-09-26 株式会社ミドリ十字 ウロキナ−ゼ誘導体
JPS54147916A (en) * 1978-05-12 1979-11-19 Sumitomo Chem Co Ltd Preparation of urokinase injection
GB2038337B (en) * 1978-12-21 1983-01-19 Green Cross Corp Process which comprises separation of urokinases having different molecular weights
SU1022988A1 (ru) * 1979-09-28 1983-06-15 Всесоюзный кардиологический научный центр АМН СССР Стабилизированна урокиназа,обладающа тромболитической активностью,и способ ее получени
US4381346A (en) * 1979-11-13 1983-04-26 Huasin Syed S Isolation of plasminogen activators useful as therapeutic and diagnostic agents

Also Published As

Publication number Publication date
IT1199522B (it) 1988-12-30
GB2150576B (en) 1987-02-25
WO1984004536A1 (en) 1984-11-22
GB2150576A (en) 1985-07-03
DE3490222T1 (de) 1985-05-02
JPS60501239A (ja) 1985-08-08
SE8500093L (sv) 1985-01-09
IT8441570A0 (it) 1984-05-09
SE442022B (sv) 1985-11-25
IT8441570A1 (it) 1985-11-09
GB8500165D0 (en) 1985-02-13
SU1128601A1 (ru) 1985-07-15
US4564596A (en) 1986-01-14
SE8500093D0 (sv) 1985-01-09

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