JPH0256330B2 - - Google Patents
Info
- Publication number
- JPH0256330B2 JPH0256330B2 JP57145431A JP14543182A JPH0256330B2 JP H0256330 B2 JPH0256330 B2 JP H0256330B2 JP 57145431 A JP57145431 A JP 57145431A JP 14543182 A JP14543182 A JP 14543182A JP H0256330 B2 JPH0256330 B2 JP H0256330B2
- Authority
- JP
- Japan
- Prior art keywords
- mitomycin
- drug
- present
- day
- japonica
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims description 46
- 229940079593 drug Drugs 0.000 claims description 31
- 239000003814 drug Substances 0.000 claims description 31
- 229960004857 mitomycin Drugs 0.000 claims description 23
- 239000000284 extract Substances 0.000 claims description 11
- 230000001093 anti-cancer Effects 0.000 claims description 10
- 201000002364 leukopenia Diseases 0.000 claims description 8
- 231100001022 leukopenia Toxicity 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 244000184734 Pyrus japonica Species 0.000 claims description 5
- 241000208422 Rhododendron Species 0.000 claims description 5
- 239000003960 organic solvent Substances 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 4
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 3
- 241000207199 Citrus Species 0.000 claims description 2
- 244000175448 Citrus madurensis Species 0.000 claims description 2
- 235000017316 Fortunella japonica Nutrition 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 235000020971 citrus fruits Nutrition 0.000 claims description 2
- 244000061520 Angelica archangelica Species 0.000 claims 1
- 230000000694 effects Effects 0.000 description 8
- 241000411851 herbal medicine Species 0.000 description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 210000000265 leukocyte Anatomy 0.000 description 3
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- 241000125175 Angelica Species 0.000 description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 2
- 238000011047 acute toxicity test Methods 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 241000092897 Angelica japonica Species 0.000 description 1
- 238000011740 C57BL/6 mouse Methods 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 240000005250 Chrysanthemum indicum Species 0.000 description 1
- 241000234653 Cyperus Species 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- 240000003421 Dianthus chinensis Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 240000004308 marijuana Species 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 210000003200 peritoneal cavity Anatomy 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57145431A JPS5936620A (ja) | 1982-08-24 | 1982-08-24 | 制癌補助剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57145431A JPS5936620A (ja) | 1982-08-24 | 1982-08-24 | 制癌補助剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5936620A JPS5936620A (ja) | 1984-02-28 |
| JPH0256330B2 true JPH0256330B2 (enrdf_load_stackoverflow) | 1990-11-29 |
Family
ID=15385081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57145431A Granted JPS5936620A (ja) | 1982-08-24 | 1982-08-24 | 制癌補助剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5936620A (enrdf_load_stackoverflow) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6195428B2 (ja) * | 2011-09-29 | 2017-09-13 | 小林製薬株式会社 | 加味四物湯エキス末を含む造粒物 |
| JPWO2013147125A1 (ja) * | 2012-03-29 | 2015-12-14 | 独立行政法人国立精神・神経医療研究センター | 薬剤取り込み増強剤 |
| CN102716320B (zh) * | 2012-07-13 | 2013-09-11 | 杨献华 | 一种治疗非小细胞肺癌的药物组合物 |
| CN104721546B (zh) * | 2015-03-20 | 2018-05-08 | 张波 | 一种防治癌症术后复发的中药组合物 |
| CN104771660A (zh) * | 2015-05-07 | 2015-07-15 | 王小华 | 治疗胃癌的中药剂及制备方法 |
| CN104800740A (zh) * | 2015-05-07 | 2015-07-29 | 王小华 | 适宜胃癌患者服用的药膳及制备方法 |
| CN104771659A (zh) * | 2015-05-07 | 2015-07-15 | 王小华 | 一种治疗胃癌的中药组合物及制备方法 |
| CN105106798A (zh) * | 2015-09-21 | 2015-12-02 | 刘兴全 | 一种防治卵巢癌的中药组合物及制备方法 |
| JP6272432B2 (ja) * | 2016-10-04 | 2018-01-31 | 小林製薬株式会社 | 加味四物湯エキス末を含む造粒物 |
-
1982
- 1982-08-24 JP JP57145431A patent/JPS5936620A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5936620A (ja) | 1984-02-28 |
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