JPH02240064A - ３―オキソ―プロパンニトリル縮合誘導体及びその製造方法 - Google Patents
３―オキソ―プロパンニトリル縮合誘導体及びその製造方法Info
- Publication number
- JPH02240064A JPH02240064A JP2027017A JP2701790A JPH02240064A JP H02240064 A JPH02240064 A JP H02240064A JP 2027017 A JP2027017 A JP 2027017A JP 2701790 A JP2701790 A JP 2701790A JP H02240064 A JPH02240064 A JP H02240064A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- group
- formula
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title description 3
- 238000009833 condensation Methods 0.000 title description 2
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- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract description 26
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 20
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- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8902596.9 | 1989-02-06 | ||
| GB8902596A GB2227741B (en) | 1989-02-06 | 1989-02-06 | Condensed 3-oxo-propanenitrile derivatives and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH02240064A true JPH02240064A (ja) | 1990-09-25 |
Family
ID=10651199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2027017A Pending JPH02240064A (ja) | 1989-02-06 | 1990-02-06 | ３―オキソ―プロパンニトリル縮合誘導体及びその製造方法 |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPH02240064A (it) |
| DE (1) | DE3940074A1 (it) |
| GB (1) | GB2227741B (it) |
| IT (1) | IT1237992B (it) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8814586D0 (en) * | 1988-06-20 | 1988-07-27 | Erba Carlo Spa | Tricyclic 3-oxo-propanenitrile derivatives & process for their preparation |
| GB8907799D0 (en) * | 1989-04-06 | 1989-05-17 | Erba Carlo Spa | Heteroaryl-3-oxo-propanenitrile derivatives useful in the treatment of rheumatoid arthritis and other autoimmune diseases |
| US5260328A (en) * | 1989-04-06 | 1993-11-09 | Farmitalia Carlo Erba Srl | Phenyl-indenopurazol 3-oxo-propanamide derivatives useful in the treatment of rheumatoid arthritis |
| US5547975A (en) * | 1994-09-20 | 1996-08-20 | Talley; John J. | Benzopyranopyrazolyl derivatives for the treatment of inflammation |
| US5886016A (en) * | 1995-09-15 | 1999-03-23 | G.D. Searle & Co. | Benzopyranopyrazolyl derivatives for the treatment of inflammation |
| GB9720899D0 (en) * | 1997-10-01 | 1997-12-03 | Pharmacia & Upjohn Spa | Condensed heterocyclic compounds |
| ES2286275T3 (es) | 2001-09-19 | 2007-12-01 | Pharmacia Corporation | Compuestos de pirazolo sustituidos para el tratamiento de la inflamacion. |
| BR0212611A (pt) | 2001-09-19 | 2004-08-17 | Pharmacia Corp | Compostos de pirazolila substituìdos para o tratamento da inflamação |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816467A (en) * | 1987-01-09 | 1989-03-28 | Farmitalia Carlo Erba S.R.L | Heteroaryl 3-oxo-propanenitrile derivatives, pharmaceutical compositions and use |
-
1989
- 1989-02-06 GB GB8902596A patent/GB2227741B/en not_active Expired - Fee Related
- 1989-12-04 DE DE3940074A patent/DE3940074A1/de not_active Withdrawn
-
1990
- 1990-01-16 IT IT01906890A patent/IT1237992B/it active IP Right Grant
- 1990-02-06 JP JP2027017A patent/JPH02240064A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GB8902596D0 (en) | 1989-03-22 |
| IT9019068A0 (it) | 1990-01-16 |
| IT1237992B (it) | 1993-06-21 |
| GB2227741B (en) | 1992-08-05 |
| GB2227741A (en) | 1990-08-08 |
| DE3940074A1 (de) | 1990-08-09 |
| IT9019068A1 (it) | 1990-08-07 |
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