JPH0212960B2 - - Google Patents
Info
- Publication number
- JPH0212960B2 JPH0212960B2 JP17647786A JP17647786A JPH0212960B2 JP H0212960 B2 JPH0212960 B2 JP H0212960B2 JP 17647786 A JP17647786 A JP 17647786A JP 17647786 A JP17647786 A JP 17647786A JP H0212960 B2 JPH0212960 B2 JP H0212960B2
- Authority
- JP
- Japan
- Prior art keywords
- temperature
- saturated solution
- ginsenoside
- water
- column chromatography
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000012047 saturated solution Substances 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- YURJSTAIMNSZAE-HHNZYBFYSA-N ginsenoside Rg1 Chemical compound O([C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(C[C@@H]([C@H]4C(C)(C)[C@@H](O)CC[C@]4(C)[C@H]3C[C@H]2O)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C)(C)CC1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YURJSTAIMNSZAE-HHNZYBFYSA-N 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 239000007787 solid Substances 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 9
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 238000004440 column chromatography Methods 0.000 description 13
- 239000013078 crystal Substances 0.000 description 11
- 239000000203 mixture Substances 0.000 description 7
- 240000004371 Panax ginseng Species 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 235000008434 ginseng Nutrition 0.000 description 5
- 235000002789 Panax ginseng Nutrition 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 230000005526 G1 to G0 transition Effects 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 3
- 235000003140 Panax quinquefolius Nutrition 0.000 description 3
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 229930182490 saponin Natural products 0.000 description 3
- 150000007949 saponins Chemical class 0.000 description 3
- 235000017709 saponins Nutrition 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- -1 ginsenoside-Rg 1 Chemical class 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000004809 thin layer chromatography Methods 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- ISGXZRIDYZBDFG-UHFFFAOYSA-N butan-1-ol;butan-2-one Chemical compound CCCCO.CCC(C)=O ISGXZRIDYZBDFG-UHFFFAOYSA-N 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 229930182494 ginsenoside Natural products 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Landscapes
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17647786A JPS6333393A (ja) | 1986-07-26 | 1986-07-26 | ジンセノサイド−Ｒｇ↓１の精製法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17647786A JPS6333393A (ja) | 1986-07-26 | 1986-07-26 | ジンセノサイド−Ｒｇ↓１の精製法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6333393A JPS6333393A (ja) | 1988-02-13 |
| JPH0212960B2 true JPH0212960B2 (fi) | 1990-03-30 |
Family
ID=16014354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17647786A Granted JPS6333393A (ja) | 1986-07-26 | 1986-07-26 | ジンセノサイド−Ｒｇ↓１の精製法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6333393A (fi) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0575638U (ja) * | 1992-03-16 | 1993-10-15 | 山武ハネウエル株式会社 | 現場型計器 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102532234A (zh) * | 2010-12-10 | 2012-07-04 | 北京本草天源药物研究院 | 一种人参皂苷Rg1的提取纯化方法 |
-
1986
- 1986-07-26 JP JP17647786A patent/JPS6333393A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0575638U (ja) * | 1992-03-16 | 1993-10-15 | 山武ハネウエル株式会社 | 現場型計器 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6333393A (ja) | 1988-02-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS62155240A (ja) | 治療用化合物 | |
| KR940002795B1 (ko) | 은행잎에서 징코라이드를 분리 및 정제하는 방법 | |
| US5430054A (en) | Preparation methods of diterpene lactone compounds and application of the same to antifertility | |
| CN112441952B (zh) | 一种大麻二酚-3-磺酸及其制备方法和应用、大麻二酚衍生物 | |
| JPS6232173B2 (fi) | ||
| US6218541B1 (en) | Method for extracting bisbenzylisoquinolines | |
| JPH0212960B2 (fi) | ||
| JPS6039647B2 (ja) | ガンマ−ｌ−グルタミル−タウリンの単離方法 | |
| CN101362746B (zh) | 阿加曲班单一立体异构体的分离方法及多晶型物 | |
| US3839317A (en) | Digoxin complexes | |
| US2348037A (en) | Vitamin and process of obtaining same | |
| JP3544223B2 (ja) | 新規な発毛・育毛促進剤 | |
| JPH0678231B2 (ja) | 血液粘度低下剤 | |
| US5233034A (en) | Process for the purification of hemin, a novel derivative and process for its preparation | |
| KR920007273B1 (ko) | 프로토카테큐알데히드류의 당유도체 | |
| JP2792010B2 (ja) | フタリド誘導体及びこれを有効成分とする子宮頚癌細胞の殺細胞剤 | |
| JP2734136B2 (ja) | オクタデセン酸誘導体及びこれを有効成分とする子宮頚癌細胞の殺細胞剤 | |
| JP3782121B2 (ja) | 新規な血行促進のために使用する医薬 | |
| CS223879B2 (en) | Method of gaining natural terpenes with antipsoriatic effect | |
| KR940002796B1 (ko) | 은행잎에서 징코라이드를 분리 및 정제하는 방법 | |
| JPH01246299A (ja) | エルゴステロール誘導体およびその製法 | |
| EP2848251B1 (en) | Extracts and isolated compounds from Cakile arabica for treatment of ulcer | |
| US4144254A (en) | Process for the purification of steroids | |
| Todd et al. | Studies on vitamin E: The isolation of some crystalline alcohols from the unsaponifiable matter of rice and wheat germ oils | |
| US2438715A (en) | Purification of dehydrocorticosterone acetate |