JPH0148758B2 - - Google Patents
Info
- Publication number
- JPH0148758B2 JPH0148758B2 JP17070886A JP17070886A JPH0148758B2 JP H0148758 B2 JPH0148758 B2 JP H0148758B2 JP 17070886 A JP17070886 A JP 17070886A JP 17070886 A JP17070886 A JP 17070886A JP H0148758 B2 JPH0148758 B2 JP H0148758B2
- Authority
- JP
- Japan
- Prior art keywords
- carbamoyl
- amino acids
- bacterial cells
- manufacturing
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000001580 bacterial effect Effects 0.000 claims description 19
- 244000005700 microbiome Species 0.000 claims description 11
- 108090000790 Enzymes Proteins 0.000 claims description 9
- 102000004190 Enzymes Human genes 0.000 claims description 9
- 239000002609 medium Substances 0.000 claims description 8
- 150000007650 D alpha amino acids Chemical class 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 239000000758 substrate Substances 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 241000191938 Micrococcus luteus Species 0.000 claims description 3
- 239000012736 aqueous medium Substances 0.000 claims description 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 3
- 241000589565 Flavobacterium Species 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 241000193830 Bacillus <bacterium> Species 0.000 claims 1
- 241000607720 Serratia Species 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 description 10
- 239000000243 solution Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 5
- ZGUNAGUHMKGQNY-SSDOTTSWSA-N D-alpha-phenylglycine Chemical compound OC(=O)[C@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-SSDOTTSWSA-N 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000008363 phosphate buffer Substances 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 2
- GIOUOHDKHHZWIQ-UHFFFAOYSA-N 2-(carbamoylamino)-2-phenylacetic acid Chemical compound NC(=O)NC(C(O)=O)C1=CC=CC=C1 GIOUOHDKHHZWIQ-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 241001468261 Lysinibacillus macroides Species 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 2
- 108010080698 Peptones Proteins 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 235000019319 peptone Nutrition 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- LSHNGTZXQYSYJQ-UHFFFAOYSA-N 2-(n-carbamoyl-4-hydroxyanilino)acetic acid Chemical compound OC(=O)CN(C(=O)N)C1=CC=C(O)C=C1 LSHNGTZXQYSYJQ-UHFFFAOYSA-N 0.000 description 1
- 241000607528 Aeromonas hydrophila Species 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000186145 Corynebacterium ammoniagenes Species 0.000 description 1
- LJCWONGJFPCTTL-SSDOTTSWSA-N D-4-hydroxyphenylglycine Chemical compound [O-]C(=O)[C@H]([NH3+])C1=CC=C(O)C=C1 LJCWONGJFPCTTL-SSDOTTSWSA-N 0.000 description 1
- 241000588697 Enterobacter cloacae Species 0.000 description 1
- 229910002570 KH2PO4-Na2HPO4 Inorganic materials 0.000 description 1
- GIOUOHDKHHZWIQ-SSDOTTSWSA-N N-carbamoyl-D-phenylglycine Chemical compound NC(=O)N[C@@H](C(O)=O)C1=CC=CC=C1 GIOUOHDKHHZWIQ-SSDOTTSWSA-N 0.000 description 1
- 241000178961 Paenibacillus alvei Species 0.000 description 1
- 241000607715 Serratia marcescens Species 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 150000001371 alpha-amino acids Chemical class 0.000 description 1
- 235000008206 alpha-amino acids Nutrition 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000003729 cation exchange resin Substances 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 150000001469 hydantoins Chemical class 0.000 description 1
- 125000004464 hydroxyphenyl group Chemical group 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000012450 pharmaceutical intermediate Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 238000002525 ultrasonication Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17070886A JPS6225990A (ja) | 1986-07-19 | 1986-07-19 | Ｄ−α−アミノ酸類の製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17070886A JPS6225990A (ja) | 1986-07-19 | 1986-07-19 | Ｄ−α−アミノ酸類の製造方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1262279A Division JPS55104890A (en) | 1979-02-06 | 1979-02-06 | Production of d-alpha-aminoacids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6225990A JPS6225990A (ja) | 1987-02-03 |
| JPH0148758B2 true JPH0148758B2 (de) | 1989-10-20 |
Family
ID=15909925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17070886A Granted JPS6225990A (ja) | 1986-07-19 | 1986-07-19 | Ｄ−α−アミノ酸類の製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6225990A (de) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994008030A1 (en) * | 1992-10-05 | 1994-04-14 | Kanegafuchi Chemical Industry Co., Ltd. | PROCESS FOR PRODUCING D-α-AMINO ACID |
| WO2006080409A1 (ja) | 2005-01-31 | 2006-08-03 | Kaneka Corporation | ５－置換ヒダントインラセマーゼ、これをコードするｄｎａ、組換えｄｎａ、形質転換された細胞、および、光学活性ｎ－カルバミルアミノ酸または光学活性アミノ酸の製造方法 |
| US9499521B2 (en) | 2014-12-11 | 2016-11-22 | President And Fellows Of Harvard College | Inhibitors of cellular necrosis and related methods |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6884607B2 (en) * | 2000-12-07 | 2005-04-26 | Sumitomo Chemical Company, Limited | Process for producing optically active 4-halo-3-hydroxybutanoate |
| DK2780451T3 (en) * | 2011-11-16 | 2018-01-02 | Evonik Technochemie Gmbh | MUTANTS OF HYDANTOINASE |
-
1986
- 1986-07-19 JP JP17070886A patent/JPS6225990A/ja active Granted
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994008030A1 (en) * | 1992-10-05 | 1994-04-14 | Kanegafuchi Chemical Industry Co., Ltd. | PROCESS FOR PRODUCING D-α-AMINO ACID |
| CN1048524C (zh) * | 1992-10-05 | 2000-01-19 | 钟渊化学工业株式会社 | D-α氨基酸的制备方法 |
| WO2006080409A1 (ja) | 2005-01-31 | 2006-08-03 | Kaneka Corporation | ５－置換ヒダントインラセマーゼ、これをコードするｄｎａ、組換えｄｎａ、形質転換された細胞、および、光学活性ｎ－カルバミルアミノ酸または光学活性アミノ酸の製造方法 |
| US9499521B2 (en) | 2014-12-11 | 2016-11-22 | President And Fellows Of Harvard College | Inhibitors of cellular necrosis and related methods |
| US9944628B2 (en) | 2014-12-11 | 2018-04-17 | President And Fellows Of Harvard College | Inhibitors of cellular necrosis and related methods |
| US10508102B2 (en) | 2014-12-11 | 2019-12-17 | President And Fellows Of Harvard College | Inhibitors of cellular necrosis and related methods |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6225990A (ja) | 1987-02-03 |
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