JPS55104890A - Production of d-alpha-aminoacids - Google Patents

Production of d-alpha-aminoacids

Info

Publication number
JPS55104890A
JPS55104890A JP1262279A JP1262279A JPS55104890A JP S55104890 A JPS55104890 A JP S55104890A JP 1262279 A JP1262279 A JP 1262279A JP 1262279 A JP1262279 A JP 1262279A JP S55104890 A JPS55104890 A JP S55104890A
Authority
JP
Japan
Prior art keywords
aminoacids
hydantoinase
carbamoyl
microorganism
act
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1262279A
Other languages
Japanese (ja)
Other versions
JPS6230758B2 (en
Inventor
Hideyuki Takahashi
Satomi Takahashi
Takehisa Ohashi
Koji Yoneda
Kiyoshi Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Priority to JP1262279A priority Critical patent/JPS55104890A/en
Priority to GB8003219A priority patent/GB2042531B/en
Priority to IT47797/80A priority patent/IT1143925B/en
Priority to BE0/199262A priority patent/BE881547A/en
Publication of JPS55104890A publication Critical patent/JPS55104890A/en
Publication of JPS6230758B2 publication Critical patent/JPS6230758B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids

Abstract

PURPOSE: A hydantoinase originating from a microorganism is made to act on 5- substituted hydantoins to produce D-N-carbamoyl-α-aminoacids.
CONSTITUTION: A microorganism, which belongs to Aerobacter, Mycobacterium, or Aspergillus and can asymmetrically cleave hydantoin rings by hydrolysis, is cultured in a medium containing pyrimidine metabolites or their analogs to form hydantoinase in the medium. The resulting culture medium, bacterium cells, their treated products, or hydantoinase extracted from the cells is made to act on 5-substituted hydantoins of formula I (R is alkyl, aralkyl, phenyl, substituted phenyl, thienyl, furyl, pyridyl, thiazolyl, imidazolyl, indolyl) to produce said D-N-carbamoyl-α-aminoacids of formula II (R is the same as the above).
COPYRIGHT: (C)1980,JPO&Japio
JP1262279A 1979-02-06 1979-02-06 Production of d-alpha-aminoacids Granted JPS55104890A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP1262279A JPS55104890A (en) 1979-02-06 1979-02-06 Production of d-alpha-aminoacids
GB8003219A GB2042531B (en) 1979-02-06 1980-01-31 Process for preparing d- -amino acids
IT47797/80A IT1143925B (en) 1979-02-06 1980-02-04 PROCEDURE FOR PREPARING D-ALFAAM MINOACIDS
BE0/199262A BE881547A (en) 1979-02-06 1980-02-05 PROCESS FOR THE PREPARATION OF D-ALPHA-AMINO ACIDS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1262279A JPS55104890A (en) 1979-02-06 1979-02-06 Production of d-alpha-aminoacids

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP17070886A Division JPS6225990A (en) 1986-07-19 1986-07-19 Production of d-alpha-amino acid

Publications (2)

Publication Number Publication Date
JPS55104890A true JPS55104890A (en) 1980-08-11
JPS6230758B2 JPS6230758B2 (en) 1987-07-03

Family

ID=11810467

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1262279A Granted JPS55104890A (en) 1979-02-06 1979-02-06 Production of d-alpha-aminoacids

Country Status (4)

Country Link
JP (1) JPS55104890A (en)
BE (1) BE881547A (en)
GB (1) GB2042531B (en)
IT (1) IT1143925B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0219034A2 (en) * 1985-10-09 1987-04-22 BASF Aktiengesellschaft Process for the preparation of mesophilic microorganisms containing D-hydantoinase active at a higher temperature
JPH01320991A (en) * 1988-06-20 1989-12-27 Kanegafuchi Chem Ind Co Ltd Production of d-homophenylalanines
JPH06508529A (en) * 1992-04-10 1994-09-29 コントロール・イ・ヘスチオン・インストゥルメンタル・ソシエダ・アノニマ Method for producing D-amino acid or D-amino acid derivative
WO2006101266A1 (en) * 2005-03-23 2006-09-28 Ajinomoto Co., Inc. Process for production of optically active hydroxymethyl -substituted phenylalanine

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3031151A1 (en) * 1980-08-18 1982-04-15 Basf Ag, 6700 Ludwigshafen METHOD FOR PRODUCING D-N-CARBAMOYL (ALPHA) AMINO ACIDS AND MICROORGANISMS THEREFOR
DK164923C (en) * 1984-04-11 1993-01-25 Denki Kagaku Kogyo Kk METHOD OF PREPARING L-ALFA AMINO ACIDS
JPS61212292A (en) * 1985-03-19 1986-09-20 Mitsui Toatsu Chem Inc Production of d-alpha-amino acid
US5283182A (en) * 1986-09-17 1994-02-01 Beecham Group Plc Preparation of immobilized hydantoinase stabilized with divalent metal ions
DE3702384A1 (en) * 1987-01-23 1988-08-04 Schering Ag METHOD FOR PRODUCING L-AMINO ACIDS
FR2620731B1 (en) * 1987-09-21 1990-03-23 Hoechst France NOVEL ENZYMATIC SYSTEM, ITS PREPARATION METHOD AND ITS APPLICATION IN PARTICULAR IN THE PREPARATION OF D-PARAHYDROXYPHENYLGLYCINE
US5824522A (en) * 1990-12-07 1998-10-20 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Recombinant decarbamylases for producing D-α-amino acids
DE10130169A1 (en) * 2001-06-22 2003-01-09 Degussa Activated rec-D hydantoinases
EP1500386A1 (en) * 2003-07-23 2005-01-26 Wella Aktiengesellschaft Method for time-dependent decrease of ph in a cosmetic composition and a composition for permanent hair shaping with time-dependent decrease of the wave-shaping efficiency

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0219034A2 (en) * 1985-10-09 1987-04-22 BASF Aktiengesellschaft Process for the preparation of mesophilic microorganisms containing D-hydantoinase active at a higher temperature
US4912044A (en) * 1985-10-09 1990-03-27 Basf Aktiengesellschaft Preparation of mesophilic microorganisms which contain a D-hydantoinase which is active at elevated temperature
JPH01320991A (en) * 1988-06-20 1989-12-27 Kanegafuchi Chem Ind Co Ltd Production of d-homophenylalanines
JPH06508529A (en) * 1992-04-10 1994-09-29 コントロール・イ・ヘスチオン・インストゥルメンタル・ソシエダ・アノニマ Method for producing D-amino acid or D-amino acid derivative
WO2006101266A1 (en) * 2005-03-23 2006-09-28 Ajinomoto Co., Inc. Process for production of optically active hydroxymethyl -substituted phenylalanine

Also Published As

Publication number Publication date
BE881547A (en) 1980-05-30
JPS6230758B2 (en) 1987-07-03
IT8047797A0 (en) 1980-02-04
IT1143925B (en) 1986-10-29
GB2042531A (en) 1980-09-24
GB2042531B (en) 1983-09-28

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