JPH0142923B2 - - Google Patents
Info
- Publication number
- JPH0142923B2 JPH0142923B2 JP55001728A JP172880A JPH0142923B2 JP H0142923 B2 JPH0142923 B2 JP H0142923B2 JP 55001728 A JP55001728 A JP 55001728A JP 172880 A JP172880 A JP 172880A JP H0142923 B2 JPH0142923 B2 JP H0142923B2
- Authority
- JP
- Japan
- Prior art keywords
- nabilone
- ethanol
- granules
- polyvinylpyrrolidone
- pvp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GECBBEABIDMGGL-RTBURBONSA-N nabilone Chemical compound C1C(=O)CC[C@H]2C(C)(C)OC3=CC(C(C)(C)CCCCCC)=CC(O)=C3[C@@H]21 GECBBEABIDMGGL-RTBURBONSA-N 0.000 claims description 15
- 229960002967 nabilone Drugs 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
- 239000008187 granular material Substances 0.000 claims description 10
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 10
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 238000005469 granulation Methods 0.000 claims description 2
- 230000003179 granulation Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000006185 dispersion Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 239000007903 gelatin capsule Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 229940124531 pharmaceutical excipient Drugs 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- CYQFCXCEBYINGO-UHFFFAOYSA-N THC Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3C21 CYQFCXCEBYINGO-UHFFFAOYSA-N 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000001430 anti-depressive effect Effects 0.000 description 1
- 230000003474 anti-emetic effect Effects 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 239000002111 antiemetic agent Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 229960004242 dronabinol Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000013020 final formulation Substances 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/019,810 US4195078A (en) | 1979-03-09 | 1979-03-09 | Nabilone granulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS55133309A JPS55133309A (en) | 1980-10-17 |
| JPH0142923B2 true JPH0142923B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1989-09-18 |
Family
ID=21795156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP172880A Granted JPS55133309A (en) | 1979-03-09 | 1980-01-10 | Granular nabilone |
Country Status (16)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4327080A (en) * | 1981-07-13 | 1982-04-27 | E. R. Squibb & Sons, Inc. | Novel Bendroflumethiazide formulations and method |
| JPS59155309A (ja) * | 1983-02-22 | 1984-09-04 | Teijin Ltd | 活性型ビタミンｄ↓３類組成物 |
| NZ211545A (en) * | 1984-04-11 | 1987-09-30 | Ici Australia Ltd | Composition having particulate trace element suspended in matrix of solid polyethylene glycol |
| US4818539A (en) * | 1985-02-05 | 1989-04-04 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
| US4747881A (en) * | 1985-02-05 | 1988-05-31 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
| US4790991A (en) * | 1985-02-05 | 1988-12-13 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
| US4843098A (en) * | 1985-02-05 | 1989-06-27 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
| US4851392A (en) * | 1985-02-05 | 1989-07-25 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
| US4844908A (en) * | 1986-11-27 | 1989-07-04 | Duphar International Research B.V. | Method of preparing tablets with clovoxamine fumarate and tablets thus prepared |
| EP0547796A1 (en) * | 1991-12-17 | 1993-06-23 | Konica Corporation | Solid chemicals for processing silver halide photographic light-sensitive material |
| US6566560B2 (en) | 1999-03-22 | 2003-05-20 | Immugen Pharmaceuticals, Inc. | Resorcinolic compounds |
| US6541510B2 (en) * | 2000-09-28 | 2003-04-01 | Immugen Pharmaceuticals, Inc. | Antiviral methods and compounds |
| WO2002026224A2 (en) * | 2000-09-28 | 2002-04-04 | Immugen Pharmaceuticals, Inc. | Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation |
| CN1652766A (zh) * | 2002-03-18 | 2005-08-10 | 免疫力药品有限公司 | 间苯二酚和大麻素的局部制剂及其施用方法 |
| CA2845443A1 (en) * | 2014-03-04 | 2015-09-04 | Pharmascience Inc. | Orally disintegrating tablet of nabilone and method of manufacturing |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR886435A (fr) * | 1941-09-29 | 1943-10-14 | Aiguille à tricoter perfectionnée | |
| US3136692A (en) * | 1961-06-30 | 1964-06-09 | Strong Cobb Arner Inc | Effervescent composition containing polyvinylpyrrolidone |
| DE1467792A1 (de) * | 1965-05-21 | 1968-12-12 | Brunnengraeber & Co Gmbh Dr Ch | Sprengmittel fuer pharmazeutische Presslinge |
| CA885974A (en) * | 1968-04-02 | 1971-11-16 | R. Telfer William | Ferrous fumarate capsule and preparation |
| IL32673A (en) * | 1968-08-05 | 1973-11-28 | Ciba Geigy Ag | A granular material containing oily or liquid therapeutically usable furanosides and a process for its manufacture |
| US3632778A (en) * | 1970-06-10 | 1972-01-04 | Hoffmann La Roche | Tablets containing l-dopa |
| NL7112288A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1970-09-16 | 1972-03-20 | ||
| JPS5418330B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1973-03-16 | 1979-07-06 | ||
| US3851032A (en) * | 1973-04-23 | 1974-11-26 | Sterling Drug Inc | Process of preparing a solid fine crystalline paracetamol polymer complex composition |
| US3864492A (en) * | 1973-08-01 | 1975-02-04 | Abbott Lab | Method of treating depression using 1,4{40 -dihydroxy-3-n-pentyl-6,6,9-trimethyl-6a,7,10,10a-tetra-hydrodibenzo{8 b,d{9 pyran |
| US3953603A (en) * | 1973-11-05 | 1976-04-27 | Eli Lilly And Company | Hexahydro-dibenzo[b,d,]pyran-9-ones as psychotropic, particularly anti-depressant drugs |
| US3920809A (en) * | 1973-11-05 | 1975-11-18 | Lilly Co Eli | Dibenzo(b,d)pyranone dispersions |
| IE39678B1 (en) * | 1973-11-05 | 1978-12-06 | Lilly Co Eli | A polymorphic form of a dibenzopyranone |
| US3987188A (en) * | 1973-11-05 | 1976-10-19 | Eli Lilly And Company | Hexahydro-dibenzo[b,d]pyran-9-ones as sedative drugs |
| US4024275A (en) * | 1973-11-05 | 1977-05-17 | Eli Lilly And Company | Method of reducing elevated blood pressure with dihydroxy-hexahydrodibenzo(b,d)pyrans |
| US3944673A (en) * | 1973-11-05 | 1976-03-16 | Eli Lilly And Company | Hexahydro-dibenzo[b,d]pyran-9-ones as analgesic drugs |
| AT329556B (de) * | 1974-10-24 | 1976-05-25 | Lilly Co Eli | Verfahren zur herstellung einer neuen stabilen polymorphen kristallinen form von 1-hydroxy-3-(1',1'-dimethylheptyl)-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9h-dibenzo(b,d)pyran-9-on |
| US4143129A (en) * | 1975-10-11 | 1979-03-06 | Lilly Industries Limited | Cephalexin tablets |
| US4087546A (en) * | 1976-02-17 | 1978-05-02 | Eli Lilly And Company | Hexahydro-dibenzo[b,d]pyran-9-ones as antiasthmatic drugs |
| US4087545A (en) * | 1976-02-17 | 1978-05-02 | Eli Lilly And Company | Hexahydro-dibenzo[b,d]pyran-9-ones as antiemetic drugs |
| US4088777A (en) * | 1976-02-17 | 1978-05-09 | Eli Lilly And Company | Hexahydro-dibenzo[b,d]pyran-9-ones as anticonvulsant drugs |
| US4087547A (en) * | 1976-02-17 | 1978-05-02 | Eli Lilly And Company | Hexahydro-dibenzo[b,d]pyran-9-ones in treatment of glaucoma |
-
1979
- 1979-03-09 US US06/019,810 patent/US4195078A/en not_active Expired - Lifetime
-
1980
- 1980-01-08 DK DK8080A patent/DK8080A/da not_active Application Discontinuation
- 1980-01-08 NZ NZ192557A patent/NZ192557A/xx unknown
- 1980-01-08 CA CA343,252A patent/CA1124178A/en not_active Expired
- 1980-01-08 ZA ZA00800104A patent/ZA80104B/xx unknown
- 1980-01-09 CH CH13880A patent/CH643840A5/fr not_active IP Right Cessation
- 1980-01-09 IL IL59098A patent/IL59098A/xx not_active IP Right Cessation
- 1980-01-09 IT IT19114/80A patent/IT1193886B/it active
- 1980-01-09 FR FR8000430A patent/FR2450606A1/fr active Granted
- 1980-01-09 BE BE1/9675A patent/BE881049A/fr not_active IP Right Cessation
- 1980-01-10 IE IE42/80A patent/IE49243B1/en not_active IP Right Cessation
- 1980-01-10 LU LU82072A patent/LU82072A1/fr unknown
- 1980-01-10 GB GB8000871A patent/GB2045080B/en not_active Expired
- 1980-01-10 EP EP80300094A patent/EP0015635A1/en not_active Ceased
- 1980-01-10 JP JP172880A patent/JPS55133309A/ja active Granted
- 1980-01-11 AU AU54554/80A patent/AU531805B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| IE800042L (en) | 1980-09-09 |
| GB2045080B (en) | 1983-05-25 |
| AU531805B2 (en) | 1983-09-08 |
| NZ192557A (en) | 1981-05-01 |
| AU5455480A (en) | 1980-09-11 |
| US4195078A (en) | 1980-03-25 |
| FR2450606B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1983-04-15 |
| CA1124178A (en) | 1982-05-25 |
| IL59098A (en) | 1983-09-30 |
| IT8019114A0 (it) | 1980-01-09 |
| GB2045080A (en) | 1980-10-29 |
| ZA80104B (en) | 1981-08-26 |
| DK8080A (da) | 1980-09-10 |
| LU82072A1 (fr) | 1980-04-23 |
| IL59098A0 (en) | 1980-05-30 |
| IE49243B1 (en) | 1985-09-04 |
| BE881049A (fr) | 1980-07-09 |
| IT1193886B (it) | 1988-08-31 |
| CH643840A5 (fr) | 1984-06-29 |
| FR2450606A1 (fr) | 1980-10-03 |
| JPS55133309A (en) | 1980-10-17 |
| EP0015635A1 (en) | 1980-09-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1280976C (en) | Process for the preparation of solid nifedipine formulations of high bioavailability and with sustained effect, and formulations thusobtained | |
| JPH0142923B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| US7976869B2 (en) | Fenofibrate tablets | |
| JPS63165318A (ja) | 光の影響に対して安定化したニフェディピン濃縮物及びその製造方法 | |
| NZ236834A (en) | Oral medicaments comprising pimobendan in dry mixture with citric acid | |
| KR100522239B1 (ko) | 아세트아미노펜을 함유하는 제어방출성의 경구용 제제 | |
| US8062664B2 (en) | Process for preparing formulations of lipid-regulating drugs | |
| JPS62228017A (ja) | ジヒドロピリジンを含有する固体の迅速放出性薬剤調製物の製造方法 | |
| CN116019815B (zh) | 一种头孢托仑匹酯药物组合物及其制备方法 | |
| JPH031288B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| JPH0797325A (ja) | 安定な固形製剤およびその製造法 | |
| EP0636023B1 (en) | Aminoguanidine spray drying process | |
| JPS58144316A (ja) | 安定なインドメタシン錠 | |
| WO2020073844A1 (zh) | 一种有效成分包含银杏萜内酯的滴丸及其制备方法 | |
| JPS6346726B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| CN112587488B (zh) | 一种水飞蓟宾组合物及其制备方法 | |
| JPH037645B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| JPH0549650B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| KR880001558B1 (ko) | 디하이드로피리딘을 함유하는 속방출성 고형약제의 제조방법 | |
| KR100432949B1 (ko) | 생체이용율이 향상된 이트라코나졸의 분립체 조성물과이를 이용한 이트라코나졸 제제 및 그 제조방법 | |
| JP5134818B2 (ja) | 脂質制御薬物製剤の製造のための方法 | |
| NO841437L (no) | Fremgangsmaate for fremstilling av orale doseringsformer av medisinsk aktive 1,4-dihydropyridin-derivater | |
| JPH02149518A (ja) | 経口投与用薬剤 | |
| US20060177512A1 (en) | Process for preparing formulations of lipid-regulating drugs | |
| WO2008022535A1 (fr) | Composition pharmaceutique pour traiter le gliome du cerveau, son procédé et sa préparation pharmaceutique |