FR2450606A1 - Procede de granulation de la trans-d1-1-hydroxy-3- (1',1'-dimethylheptyl)-6,6-dimethyl-6a, 7, 8, 9, 10, 10a-hexahydrodibenzo(b,d)pyran-9-one (nabilone) - Google Patents

Procede de granulation de la trans-d1-1-hydroxy-3- (1',1'-dimethylheptyl)-6,6-dimethyl-6a, 7, 8, 9, 10, 10a-hexahydrodibenzo(b,d)pyran-9-one (nabilone)

Info

Publication number
FR2450606A1
FR2450606A1 FR8000430A FR8000430A FR2450606A1 FR 2450606 A1 FR2450606 A1 FR 2450606A1 FR 8000430 A FR8000430 A FR 8000430A FR 8000430 A FR8000430 A FR 8000430A FR 2450606 A1 FR2450606 A1 FR 2450606A1
Authority
FR
France
Prior art keywords
nabilone
hexahydrodibenzo
dimethylheptyl
pyran
granulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8000430A
Other languages
English (en)
Other versions
FR2450606B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of FR2450606A1 publication Critical patent/FR2450606A1/fr
Application granted granted Critical
Publication of FR2450606B1 publication Critical patent/FR2450606B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

PROCEDE DE PREPARATION DE LA NABILONE EN VUE DE SON ADMINISTRATION PAR VOIE ORALE A DES MAMMIFERES, CARACTERISE EN CE QU'ON DISSOUT LA NABILONE ET DE LA POLYVINYLPYRROLIDONE OU DU POLYETHYLENEGLYCOL DANS DE L'ETHANOL ANHYDRE ET ON UTILISE LA SOLUTION VISQUEUSE AINSI FORMEE POUR GRANULER UN EXCIPIENT INSOLUBLE DANS L'ETHANOL ET ACCEPTABLE SUR LE PLAN PHARMACEUTIQUE, PAR MELANGE SOIGNEUX DE LA SOLUTION AVEC L'EXCIPIENT PUIS SECHAGE DU PRODUIT GRANULE AINSI FORME.
FR8000430A 1979-03-09 1980-01-09 Procede de granulation de la trans-d1-1-hydroxy-3- (1',1'-dimethylheptyl)-6,6-dimethyl-6a, 7, 8, 9, 10, 10a-hexahydrodibenzo(b,d)pyran-9-one (nabilone) Granted FR2450606A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/019,810 US4195078A (en) 1979-03-09 1979-03-09 Nabilone granulation

Publications (2)

Publication Number Publication Date
FR2450606A1 true FR2450606A1 (fr) 1980-10-03
FR2450606B1 FR2450606B1 (fr) 1983-04-15

Family

ID=21795156

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8000430A Granted FR2450606A1 (fr) 1979-03-09 1980-01-09 Procede de granulation de la trans-d1-1-hydroxy-3- (1',1'-dimethylheptyl)-6,6-dimethyl-6a, 7, 8, 9, 10, 10a-hexahydrodibenzo(b,d)pyran-9-one (nabilone)

Country Status (16)

Country Link
US (1) US4195078A (fr)
EP (1) EP0015635A1 (fr)
JP (1) JPS55133309A (fr)
AU (1) AU531805B2 (fr)
BE (1) BE881049A (fr)
CA (1) CA1124178A (fr)
CH (1) CH643840A5 (fr)
DK (1) DK8080A (fr)
FR (1) FR2450606A1 (fr)
GB (1) GB2045080B (fr)
IE (1) IE49243B1 (fr)
IL (1) IL59098A (fr)
IT (1) IT1193886B (fr)
LU (1) LU82072A1 (fr)
NZ (1) NZ192557A (fr)
ZA (1) ZA80104B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4327080A (en) * 1981-07-13 1982-04-27 E. R. Squibb & Sons, Inc. Novel Bendroflumethiazide formulations and method
JPS59155309A (ja) * 1983-02-22 1984-09-04 Teijin Ltd 活性型ビタミンｄ↓３類組成物
NZ211545A (en) * 1984-04-11 1987-09-30 Ici Australia Ltd Composition having particulate trace element suspended in matrix of solid polyethylene glycol
US4818539A (en) * 1985-02-05 1989-04-04 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4747881A (en) * 1985-02-05 1988-05-31 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4851392A (en) * 1985-02-05 1989-07-25 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4843098A (en) * 1985-02-05 1989-06-27 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4790991A (en) * 1985-02-05 1988-12-13 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4844908A (en) * 1986-11-27 1989-07-04 Duphar International Research B.V. Method of preparing tablets with clovoxamine fumarate and tablets thus prepared
EP0547796A1 (fr) * 1991-12-17 1993-06-23 Konica Corporation Composés chimique sous forme solide utilisé dans la traitement d'un matériau photographique à l'halogénure d'argent sensible à la lumière
US6566560B2 (en) 1999-03-22 2003-05-20 Immugen Pharmaceuticals, Inc. Resorcinolic compounds
AU2001296402A1 (en) * 2000-09-28 2002-04-08 Immugen Pharmaceuticals, Inc. Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation
AU2002213429A1 (en) * 2000-09-28 2002-04-08 Immugen Pharmaceuticals, Inc. Antiviral methods and compounds
AU2003214226A1 (en) * 2002-03-18 2003-10-08 Immugen Pharmaceuticals, Inc. Topical formulations of resorcinols and cannibinoids and methods of use
CA2845443A1 (fr) * 2014-03-04 2015-09-04 Pharmascience Inc. Comprime de nabilone se desintegrant en bouche et methode de fabrication associee

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR886435A (fr) * 1941-09-29 1943-10-14 Aiguille à tricoter perfectionnée

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3136692A (en) * 1961-06-30 1964-06-09 Strong Cobb Arner Inc Effervescent composition containing polyvinylpyrrolidone
DE1467792A1 (de) * 1965-05-21 1968-12-12 Brunnengraeber & Co Gmbh Dr Ch Sprengmittel fuer pharmazeutische Presslinge
CA885974A (en) * 1968-04-02 1971-11-16 R. Telfer William Ferrous fumarate capsule and preparation
IL32673A (en) * 1968-08-05 1973-11-28 Ciba Geigy Ag A granular material containing oily or liquid therapeutically usable furanosides and a process for its manufacture
US3632778A (en) * 1970-06-10 1972-01-04 Hoffmann La Roche Tablets containing l-dopa
NL7112288A (fr) * 1970-09-16 1972-03-20
JPS5418330B2 (fr) * 1973-03-16 1979-07-06
US3851032A (en) * 1973-04-23 1974-11-26 Sterling Drug Inc Process of preparing a solid fine crystalline paracetamol polymer complex composition
US3864492A (en) * 1973-08-01 1975-02-04 Abbott Lab Method of treating depression using 1,4{40 -dihydroxy-3-n-pentyl-6,6,9-trimethyl-6a,7,10,10a-tetra-hydrodibenzo{8 b,d{9 pyran
US3920809A (en) * 1973-11-05 1975-11-18 Lilly Co Eli Dibenzo(b,d)pyranone dispersions
US3953603A (en) * 1973-11-05 1976-04-27 Eli Lilly And Company Hexahydro-dibenzo[b,d,]pyran-9-ones as psychotropic, particularly anti-depressant drugs
US3987188A (en) * 1973-11-05 1976-10-19 Eli Lilly And Company Hexahydro-dibenzo[b,d]pyran-9-ones as sedative drugs
US4024275A (en) * 1973-11-05 1977-05-17 Eli Lilly And Company Method of reducing elevated blood pressure with dihydroxy-hexahydrodibenzo(b,d)pyrans
US3944673A (en) * 1973-11-05 1976-03-16 Eli Lilly And Company Hexahydro-dibenzo[b,d]pyran-9-ones as analgesic drugs
IE39678B1 (en) * 1973-11-05 1978-12-06 Lilly Co Eli A polymorphic form of a dibenzopyranone
AT329556B (de) * 1974-10-24 1976-05-25 Lilly Co Eli Verfahren zur herstellung einer neuen stabilen polymorphen kristallinen form von 1-hydroxy-3-(1',1'-dimethylheptyl)-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9h-dibenzo(b,d)pyran-9-on
US4143129A (en) * 1975-10-11 1979-03-06 Lilly Industries Limited Cephalexin tablets
US4087545A (en) * 1976-02-17 1978-05-02 Eli Lilly And Company Hexahydro-dibenzo[b,d]pyran-9-ones as antiemetic drugs
US4087546A (en) * 1976-02-17 1978-05-02 Eli Lilly And Company Hexahydro-dibenzo[b,d]pyran-9-ones as antiasthmatic drugs
US4087547A (en) * 1976-02-17 1978-05-02 Eli Lilly And Company Hexahydro-dibenzo[b,d]pyran-9-ones in treatment of glaucoma
US4088777A (en) * 1976-02-17 1978-05-09 Eli Lilly And Company Hexahydro-dibenzo[b,d]pyran-9-ones as anticonvulsant drugs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR886435A (fr) * 1941-09-29 1943-10-14 Aiguille à tricoter perfectionnée

Also Published As

Publication number Publication date
EP0015635A1 (fr) 1980-09-17
IL59098A0 (en) 1980-05-30
IL59098A (en) 1983-09-30
GB2045080A (en) 1980-10-29
GB2045080B (en) 1983-05-25
US4195078A (en) 1980-03-25
AU531805B2 (en) 1983-09-08
ZA80104B (en) 1981-08-26
AU5455480A (en) 1980-09-11
IE49243B1 (en) 1985-09-04
IT8019114A0 (it) 1980-01-09
BE881049A (fr) 1980-07-09
CA1124178A (fr) 1982-05-25
FR2450606B1 (fr) 1983-04-15
JPS55133309A (en) 1980-10-17
IE800042L (en) 1980-09-09
CH643840A5 (fr) 1984-06-29
DK8080A (da) 1980-09-10
IT1193886B (it) 1988-08-31
NZ192557A (en) 1981-05-01
JPH0142923B2 (fr) 1989-09-18
LU82072A1 (fr) 1980-04-23

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