JPH0142279B2 - - Google Patents
Info
- Publication number
- JPH0142279B2 JPH0142279B2 JP58041358A JP4135883A JPH0142279B2 JP H0142279 B2 JPH0142279 B2 JP H0142279B2 JP 58041358 A JP58041358 A JP 58041358A JP 4135883 A JP4135883 A JP 4135883A JP H0142279 B2 JPH0142279 B2 JP H0142279B2
- Authority
- JP
- Japan
- Prior art keywords
- leu
- glu
- thr
- lys
- asn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108090000623 proteins and genes Proteins 0.000 claims description 49
- 230000000694 effects Effects 0.000 claims description 42
- 150000001413 amino acids Chemical group 0.000 claims description 41
- 229920001184 polypeptide Polymers 0.000 claims description 34
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 34
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 33
- 102000004169 proteins and genes Human genes 0.000 claims description 21
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 claims description 13
- WDIYWDJLXOCGRW-ACZMJKKPSA-N Ala-Asp-Glu Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O WDIYWDJLXOCGRW-ACZMJKKPSA-N 0.000 claims description 6
- MVBWLRJESQOQTM-ACZMJKKPSA-N Ala-Gln-Ser Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(O)=O MVBWLRJESQOQTM-ACZMJKKPSA-N 0.000 claims description 6
- OISWSORSLQOGFV-AVGNSLFASA-N Arg-Met-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CCCN=C(N)N OISWSORSLQOGFV-AVGNSLFASA-N 0.000 claims description 6
- POZKLUIXMHIULG-FDARSICLSA-N Arg-Trp-Ile Chemical compound CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@H](CCCN=C(N)N)N POZKLUIXMHIULG-FDARSICLSA-N 0.000 claims description 6
- PTSDPWIHOYMRGR-UGYAYLCHSA-N Asn-Ile-Asn Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(O)=O PTSDPWIHOYMRGR-UGYAYLCHSA-N 0.000 claims description 6
- XLLSMEFANRROJE-GUBZILKMSA-N Cys-Leu-Glu Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)O)NC(=O)[C@H](CS)N XLLSMEFANRROJE-GUBZILKMSA-N 0.000 claims description 6
- SXFPZRRVWSUYII-KBIXCLLPSA-N Gln-Ser-Ile Chemical compound CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)N)N SXFPZRRVWSUYII-KBIXCLLPSA-N 0.000 claims description 6
- MUSGDMDGNGXULI-DCAQKATOSA-N Glu-Glu-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CCC(O)=O MUSGDMDGNGXULI-DCAQKATOSA-N 0.000 claims description 6
- QJCKNLPMTPXXEM-AUTRQRHGSA-N Glu-Glu-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CCC(O)=O QJCKNLPMTPXXEM-AUTRQRHGSA-N 0.000 claims description 6
- IVGJYOOGJLFKQE-AVGNSLFASA-N Glu-Leu-Lys Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCC(=O)O)N IVGJYOOGJLFKQE-AVGNSLFASA-N 0.000 claims description 6
- CAQXJMUDOLSBPF-SUSMZKCASA-N Glu-Thr-Thr Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O CAQXJMUDOLSBPF-SUSMZKCASA-N 0.000 claims description 6
- SKYULSWNBYAQMG-IHRRRGAJSA-N His-Leu-Arg Chemical compound [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O SKYULSWNBYAQMG-IHRRRGAJSA-N 0.000 claims description 6
- UROVZOUMHNXPLZ-AVGNSLFASA-N His-Leu-Gln Chemical compound NC(=O)CC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC1=CN=CN1 UROVZOUMHNXPLZ-AVGNSLFASA-N 0.000 claims description 6
- RQJUKVXWAKJDBW-SVSWQMSJSA-N Ile-Ser-Thr Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)O)N RQJUKVXWAKJDBW-SVSWQMSJSA-N 0.000 claims description 6
- YWCJXQKATPNPOE-UKJIMTQDSA-N Ile-Val-Glu Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)O)N YWCJXQKATPNPOE-UKJIMTQDSA-N 0.000 claims description 6
- IBMVEYRWAWIOTN-UHFFFAOYSA-N L-Leucyl-L-Arginyl-L-Proline Natural products CC(C)CC(N)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(O)=O IBMVEYRWAWIOTN-UHFFFAOYSA-N 0.000 claims description 6
- JKGHDYGZRDWHGA-SRVKXCTJSA-N Leu-Asn-Leu Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(O)=O JKGHDYGZRDWHGA-SRVKXCTJSA-N 0.000 claims description 6
- QVFGXCVIXXBFHO-AVGNSLFASA-N Leu-Glu-Leu Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(O)=O QVFGXCVIXXBFHO-AVGNSLFASA-N 0.000 claims description 6
- HRTRLSRYZZKPCO-BJDJZHNGSA-N Leu-Ile-Ser Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(O)=O HRTRLSRYZZKPCO-BJDJZHNGSA-N 0.000 claims description 6
- KNKHAVVBVXKOGX-JXUBOQSCSA-N Lys-Ala-Thr Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O KNKHAVVBVXKOGX-JXUBOQSCSA-N 0.000 claims description 6
- YVSHZSUKQHNDHD-KKUMJFAQSA-N Lys-Asn-Phe Chemical compound C1=CC=C(C=C1)C[C@@H](C(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCCCN)N YVSHZSUKQHNDHD-KKUMJFAQSA-N 0.000 claims description 6
- FHIAJWBDZVHLAH-YUMQZZPRSA-N Lys-Gly-Ser Chemical compound NCCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CO)C(O)=O FHIAJWBDZVHLAH-YUMQZZPRSA-N 0.000 claims description 6
- HYSVGEAWTGPMOA-IHRRRGAJSA-N Lys-Pro-Leu Chemical compound [H]N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(O)=O HYSVGEAWTGPMOA-IHRRRGAJSA-N 0.000 claims description 6
- WXXNVZMWHOLNRJ-AVGNSLFASA-N Met-Pro-Lys Chemical compound CSCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(O)=O WXXNVZMWHOLNRJ-AVGNSLFASA-N 0.000 claims description 6
- XMBSYZWANAQXEV-UHFFFAOYSA-N N-alpha-L-glutamyl-L-phenylalanine Natural products OC(=O)CCC(N)C(=O)NC(C(O)=O)CC1=CC=CC=C1 XMBSYZWANAQXEV-UHFFFAOYSA-N 0.000 claims description 6
- KBVJZCVLQWCJQN-KKUMJFAQSA-N Phe-Leu-Asn Chemical compound [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O KBVJZCVLQWCJQN-KKUMJFAQSA-N 0.000 claims description 6
- VHDNDCPMHQMXIR-IHRRRGAJSA-N Phe-Met-Cys Chemical compound SC[C@@H](C(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC1=CC=CC=C1 VHDNDCPMHQMXIR-IHRRRGAJSA-N 0.000 claims description 6
- SSSFPISOZOLQNP-GUBZILKMSA-N Pro-Arg-Asp Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(O)=O SSSFPISOZOLQNP-GUBZILKMSA-N 0.000 claims description 6
- CAJFZCICSVBOJK-SHGPDSBTSA-N Thr-Ala-Thr Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O CAJFZCICSVBOJK-SHGPDSBTSA-N 0.000 claims description 6
- UGFSAPWZBROURT-IXOXFDKPSA-N Thr-Phe-Cys Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CS)C(=O)O)N)O UGFSAPWZBROURT-IXOXFDKPSA-N 0.000 claims description 6
- VGYVVSQFSSKZRJ-OEAJRASXSA-N Thr-Phe-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)[C@H](O)C)CC1=CC=CC=C1 VGYVVSQFSSKZRJ-OEAJRASXSA-N 0.000 claims description 6
- DJQIUOKSNRBTSV-CYDGBPFRSA-N Val-Ile-Val Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](C(C)C)C(=O)O)NC(=O)[C@H](C(C)C)N DJQIUOKSNRBTSV-CYDGBPFRSA-N 0.000 claims description 6
- KOSRFJWDECSPRO-UHFFFAOYSA-N alpha-L-glutamyl-L-glutamic acid Natural products OC(=O)CCC(N)C(=O)NC(CCC(O)=O)C(O)=O KOSRFJWDECSPRO-UHFFFAOYSA-N 0.000 claims description 6
- 108010055341 glutamyl-glutamic acid Proteins 0.000 claims description 6
- 108010092114 histidylphenylalanine Proteins 0.000 claims description 6
- 108010034529 leucyl-lysine Proteins 0.000 claims description 6
- 108010090333 leucyl-lysyl-proline Proteins 0.000 claims description 6
- 108010054155 lysyllysine Proteins 0.000 claims description 6
- 108010038320 lysylphenylalanine Proteins 0.000 claims description 6
- AWXDRZJQCVHCIT-DCAQKATOSA-N Asn-Pro-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CC(N)=O AWXDRZJQCVHCIT-DCAQKATOSA-N 0.000 claims description 4
- QNNBHTFDFFFHGC-KKUMJFAQSA-N Asn-Tyr-Lys Chemical compound C1=CC(=CC=C1C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CC(=O)N)N)O QNNBHTFDFFFHGC-KKUMJFAQSA-N 0.000 claims description 4
- LGIKBBLQVSWUGK-DCAQKATOSA-N Gln-Leu-Gln Chemical compound [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O LGIKBBLQVSWUGK-DCAQKATOSA-N 0.000 claims description 4
- DGKBSGNCMCLDSL-BYULHYEWSA-N Gly-Ile-Asn Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)CN DGKBSGNCMCLDSL-BYULHYEWSA-N 0.000 claims description 4
- TWYOYAKMLHWMOJ-ZPFDUUQYSA-N Ile-Leu-Asn Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O TWYOYAKMLHWMOJ-ZPFDUUQYSA-N 0.000 claims description 4
- AXZGZMGRBDQTEY-SRVKXCTJSA-N Leu-Gln-Met Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(O)=O AXZGZMGRBDQTEY-SRVKXCTJSA-N 0.000 claims description 4
- IWTBYNQNAPECCS-AVGNSLFASA-N Leu-Glu-His Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(O)=O)CC1=CN=CN1 IWTBYNQNAPECCS-AVGNSLFASA-N 0.000 claims description 4
- PDQDCFBVYXEFSD-SRVKXCTJSA-N Leu-Leu-Asp Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O PDQDCFBVYXEFSD-SRVKXCTJSA-N 0.000 claims description 4
- PLDJDCJLRCYPJB-VOAKCMCISA-N Lys-Lys-Thr Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O PLDJDCJLRCYPJB-VOAKCMCISA-N 0.000 claims description 4
- RMJZWERKFFNNNS-XGEHTFHBSA-N Pro-Thr-Ser Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(O)=O RMJZWERKFFNNNS-XGEHTFHBSA-N 0.000 claims description 4
- PYTKULIABVRXSC-BWBBJGPYSA-N Ser-Ser-Thr Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(O)=O PYTKULIABVRXSC-BWBBJGPYSA-N 0.000 claims description 4
- 108010025306 histidylleucine Proteins 0.000 claims description 4
- 102000055277 human IL2 Human genes 0.000 claims description 3
- FFZJHQODAYHGPO-KZVJFYERSA-N Ala-Pro-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N FFZJHQODAYHGPO-KZVJFYERSA-N 0.000 claims description 2
- QKCZZAZNMMVICF-DCAQKATOSA-N Gln-Leu-Glu Chemical compound NC(=O)CC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(O)=O QKCZZAZNMMVICF-DCAQKATOSA-N 0.000 claims description 2
- DOMHVQBSRJNNKD-ZPFDUUQYSA-N Gln-Met-Ile Chemical compound [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O DOMHVQBSRJNNKD-ZPFDUUQYSA-N 0.000 claims description 2
- YAALVYQFVJNXIV-KKUMJFAQSA-N His-Leu-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC1=CN=CN1 YAALVYQFVJNXIV-KKUMJFAQSA-N 0.000 claims description 2
- QYZYJFXHXYUZMZ-UGYAYLCHSA-N Ile-Asn-Asn Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)O)N QYZYJFXHXYUZMZ-UGYAYLCHSA-N 0.000 claims description 2
- OIARJGNVARWKFP-YUMQZZPRSA-N Leu-Asn-Gly Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(O)=O OIARJGNVARWKFP-YUMQZZPRSA-N 0.000 claims description 2
- DLCOFDAHNMMQPP-SRVKXCTJSA-N Leu-Asp-Leu Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(O)=O DLCOFDAHNMMQPP-SRVKXCTJSA-N 0.000 claims description 2
- RMODQFBNDDENCP-IHRRRGAJSA-N Pro-Lys-Leu Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O RMODQFBNDDENCP-IHRRRGAJSA-N 0.000 claims description 2
- XQJCEKXQUJQNNK-ZLUOBGJFSA-N Ser-Ser-Ser Chemical compound OC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(O)=O XQJCEKXQUJQNNK-ZLUOBGJFSA-N 0.000 claims description 2
- RKDFEMGVMMYYNG-WDCWCFNPSA-N Thr-Gln-Leu Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(O)=O RKDFEMGVMMYYNG-WDCWCFNPSA-N 0.000 claims description 2
- MGJLBZFUXUGMML-VOAKCMCISA-N Thr-Lys-Lys Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)N)O MGJLBZFUXUGMML-VOAKCMCISA-N 0.000 claims description 2
- GITNQBVCEQBDQC-KKUMJFAQSA-N Tyr-Lys-Asn Chemical compound [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(O)=O GITNQBVCEQBDQC-KKUMJFAQSA-N 0.000 claims description 2
- 108010077245 asparaginyl-proline Proteins 0.000 claims description 2
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- 108010002350 Interleukin-2 Proteins 0.000 description 163
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- 102000004594 DNA Polymerase I Human genes 0.000 description 7
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- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 7
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- 229930006000 Sucrose Natural products 0.000 description 6
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Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP83101035A EP0091539B2 (fr) | 1982-03-31 | 1983-02-03 | Gène codant pour interleukin-2 polypeptide, ADN recombinant portant ledit gène, lignées cellulaires possédant le recombinant ADN et procédé pour la préparation d'interleukin-2 utilisant lesdites cellules |
GB83101035.0 | 1983-02-03 |
Related Child Applications (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP24051583A Division JPS6034999A (ja) | 1983-12-20 | 1983-12-20 | ポリペプチド |
JP59120492A Division JPS6034915A (ja) | 1983-02-03 | 1984-06-12 | ポリペプチド |
JP1109060A Division JPH0659219B2 (ja) | 1983-02-03 | 1989-05-01 | ヒトインターロイキン2活性をもつポリペプチドをコートする遺伝子 |
JP1109059A Division JPH0698000B2 (ja) | 1983-02-03 | 1989-05-01 | ヒトインターロイキン2活性をもつポリペプチドをコードする遺伝子 |
JP1109062A Division JPH0832239B2 (ja) | 1983-02-03 | 1989-05-01 | ヒトインターロイキン2活性を有するポリペプチドをコードする遺伝子を含有する組換えdna体および該組換えdna体により形質転換された原核生物細胞 |
JP1109061A Division JPH0659220B2 (ja) | 1983-02-03 | 1989-05-01 | ヒトインターロイキン2活性をもつポリペプチドをコードする遺伝子 |
JP1109058A Division JPH0832238B2 (ja) | 1983-02-03 | 1989-05-01 | ヒトインターロイキン2活性をもつポリペプチドの製造法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS59144719A JPS59144719A (ja) | 1984-08-18 |
JPH0142279B2 true JPH0142279B2 (fr) | 1989-09-11 |
Family
ID=8190276
Family Applications (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP58041358A Granted JPS59144719A (ja) | 1983-02-03 | 1983-03-12 | ヒトインタ―ロイキン2活性を有するポリペプチド |
JP59120492A Pending JPS6034915A (ja) | 1983-02-03 | 1984-06-12 | ポリペプチド |
JP1109061A Expired - Lifetime JPH0659220B2 (ja) | 1983-02-03 | 1989-05-01 | ヒトインターロイキン2活性をもつポリペプチドをコードする遺伝子 |
JP1109058A Expired - Lifetime JPH0832238B2 (ja) | 1983-02-03 | 1989-05-01 | ヒトインターロイキン2活性をもつポリペプチドの製造法 |
JP1109059A Expired - Lifetime JPH0698000B2 (ja) | 1983-02-03 | 1989-05-01 | ヒトインターロイキン2活性をもつポリペプチドをコードする遺伝子 |
JP1109062A Expired - Lifetime JPH0832239B2 (ja) | 1983-02-03 | 1989-05-01 | ヒトインターロイキン2活性を有するポリペプチドをコードする遺伝子を含有する組換えdna体および該組換えdna体により形質転換された原核生物細胞 |
JP1109060A Expired - Lifetime JPH0659219B2 (ja) | 1983-02-03 | 1989-05-01 | ヒトインターロイキン2活性をもつポリペプチドをコートする遺伝子 |
Family Applications After (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP59120492A Pending JPS6034915A (ja) | 1983-02-03 | 1984-06-12 | ポリペプチド |
JP1109061A Expired - Lifetime JPH0659220B2 (ja) | 1983-02-03 | 1989-05-01 | ヒトインターロイキン2活性をもつポリペプチドをコードする遺伝子 |
JP1109058A Expired - Lifetime JPH0832238B2 (ja) | 1983-02-03 | 1989-05-01 | ヒトインターロイキン2活性をもつポリペプチドの製造法 |
JP1109059A Expired - Lifetime JPH0698000B2 (ja) | 1983-02-03 | 1989-05-01 | ヒトインターロイキン2活性をもつポリペプチドをコードする遺伝子 |
JP1109062A Expired - Lifetime JPH0832239B2 (ja) | 1983-02-03 | 1989-05-01 | ヒトインターロイキン2活性を有するポリペプチドをコードする遺伝子を含有する組換えdna体および該組換えdna体により形質転換された原核生物細胞 |
JP1109060A Expired - Lifetime JPH0659219B2 (ja) | 1983-02-03 | 1989-05-01 | ヒトインターロイキン2活性をもつポリペプチドをコートする遺伝子 |
Country Status (2)
Country | Link |
---|---|
JP (7) | JPS59144719A (fr) |
SU (1) | SU1479005A3 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8303383D0 (en) * | 1983-02-08 | 1983-03-16 | Biogen Nv | Sequences recombinant dna molecules |
AU579089B2 (en) * | 1983-02-08 | 1988-11-17 | Biogen, Inc. | Human interleukin-2-like polypeptides |
CA1340853C (fr) * | 1983-12-23 | 1999-12-21 | Hsiang-Fu Kung | Purification d'une interleukine-2 recombinante |
WO1986006405A1 (fr) * | 1985-05-02 | 1986-11-06 | Takeda Chemical Industries, Ltd. | Nouveau transformateur et son utilisation |
WO1986006410A1 (fr) * | 1985-04-30 | 1986-11-06 | Takeda Chemical Industries, Ltd. | Procede d'augmentation de la production d'interleucine-2 |
JPS62185098A (ja) * | 1986-02-10 | 1987-08-13 | Otsuka Pharmaceut Co Ltd | インタ−ロイキン−2活性を有するポリペプチド |
KR101041986B1 (ko) * | 2008-03-06 | 2011-06-16 | (주)한국비엠아이 | 인간 인터루킨-2의 대량 생산을 위한 신규한 균주 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6419879A (en) * | 1987-07-15 | 1989-01-23 | Asahi Optical Co Ltd | Tv viewer |
-
1983
- 1983-03-12 JP JP58041358A patent/JPS59144719A/ja active Granted
- 1983-12-14 SU SU833679351A patent/SU1479005A3/ru active
-
1984
- 1984-06-12 JP JP59120492A patent/JPS6034915A/ja active Pending
-
1989
- 1989-05-01 JP JP1109061A patent/JPH0659220B2/ja not_active Expired - Lifetime
- 1989-05-01 JP JP1109058A patent/JPH0832238B2/ja not_active Expired - Lifetime
- 1989-05-01 JP JP1109059A patent/JPH0698000B2/ja not_active Expired - Lifetime
- 1989-05-01 JP JP1109062A patent/JPH0832239B2/ja not_active Expired - Lifetime
- 1989-05-01 JP JP1109060A patent/JPH0659219B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH0335795A (ja) | 1991-02-15 |
JPH02195887A (ja) | 1990-08-02 |
JPH0698000B2 (ja) | 1994-12-07 |
JPH02200189A (ja) | 1990-08-08 |
JPH0832239B2 (ja) | 1996-03-29 |
JPH02195888A (ja) | 1990-08-02 |
JPS59144719A (ja) | 1984-08-18 |
JPS6034915A (ja) | 1985-02-22 |
JPH0659219B2 (ja) | 1994-08-10 |
JPH0659220B2 (ja) | 1994-08-10 |
SU1479005A3 (ru) | 1989-05-07 |
JPH0832238B2 (ja) | 1996-03-29 |
JPH02195886A (ja) | 1990-08-02 |
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