JP7847578B2 - Ｆｌｔ３リガンド融合タンパク質及び使用方法 - Google Patents

Ｆｌｔ３リガンド融合タンパク質及び使用方法

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Publication number
JP7847578B2
JP7847578B2 JP2023507882A JP2023507882A JP7847578B2 JP 7847578 B2 JP7847578 B2 JP 7847578B2 JP 2023507882 A JP2023507882 A JP 2023507882A JP 2023507882 A JP2023507882 A JP 2023507882A JP 7847578 B2 JP7847578 B2 JP 7847578B2
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Japan
Prior art keywords
flt3l
seq
fusion protein
protein
amino acid
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JP2023507882A
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English (en)
Japanese (ja)
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JP2023536655A5 (enExample
JP2023536655A (ja
Inventor
イーチン リウ，
クリスティーン カリーヌ ムシオン，
トラヴィス ウィリアム ベインブリッジ，
イーラジ ホッセイニ，
グレゴリー アラン ラザー，
シヴァン コーエン，
クリストファー チャールズ ケンバル，
ジル エム． シャルトナー，
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Genentech Inc
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Genentech Inc
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Publication of JP2023536655A publication Critical patent/JP2023536655A/ja
Publication of JP2023536655A5 publication Critical patent/JP2023536655A5/ja
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Publication of JP7847578B2 publication Critical patent/JP7847578B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2023507882A 2020-08-07 2021-08-05 Ｆｌｔ３リガンド融合タンパク質及び使用方法 Active JP7847578B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063062713P 2020-08-07 2020-08-07
US63/062,713 2020-08-07
PCT/US2021/044586 WO2022031876A1 (en) 2020-08-07 2021-08-05 Flt3 ligand fusion proteins and methods of use

Publications (3)

Publication Number Publication Date
JP2023536655A JP2023536655A (ja) 2023-08-28
JP2023536655A5 JP2023536655A5 (enExample) 2024-08-13
JP7847578B2 true JP7847578B2 (ja) 2026-04-17

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US (2) US11542308B2 (enExample)
EP (1) EP4192854A1 (enExample)
JP (1) JP7847578B2 (enExample)
KR (1) KR20230042596A (enExample)
CN (1) CN116234830A (enExample)
AR (1) AR123158A1 (enExample)
AU (1) AU2021322239A1 (enExample)
BR (1) BR112023002123A2 (enExample)
CA (1) CA3188426A1 (enExample)
CL (1) CL2023000381A1 (enExample)
CO (1) CO2023001488A2 (enExample)
CR (1) CR20230119A (enExample)
IL (1) IL300260A (enExample)
MX (2) MX2023001440A (enExample)
PE (1) PE20230983A1 (enExample)
TW (1) TW202221016A (enExample)
WO (1) WO2022031876A1 (enExample)
ZA (1) ZA202300862B (enExample)

Families Citing this family (5)

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PE20230983A1 (es) * 2020-08-07 2023-06-21 Genentech Inc Proteinas de fusion del ligando para flt3 y metodos de uso
TW202313094A (zh) 2021-05-18 2023-04-01 美商基利科學股份有限公司 使用ＦＬＴ３Ｌ—Ｆｃ融合蛋白之方法
JP7673255B2 (ja) 2021-06-11 2025-05-08 ギリアード サイエンシーズ， インコーポレイテッド Ｍｃｌ－１阻害剤と抗体薬物コンジュゲートとの組み合わせ
TWI910028B (zh) 2021-06-11 2025-12-21 美商基利科學股份有限公司 Mcl-1抑制劑與抗癌劑之組合
EP4532728A2 (en) * 2022-06-03 2025-04-09 The University of Chicago Antigen tolerance induction through use of flt3l variants

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MX2023001440A (es) 2023-03-06
EP4192854A1 (en) 2023-06-14
PE20230983A1 (es) 2023-06-21
US20220289803A1 (en) 2022-09-15
MX2023001441A (es) 2023-03-06
KR20230042596A (ko) 2023-03-28
CL2023000381A1 (es) 2023-07-28
IL300260A (en) 2023-03-01
CA3188426A1 (en) 2022-02-10
CN116234830A (zh) 2023-06-06
WO2022031876A1 (en) 2022-02-10
CR20230119A (es) 2023-05-16
AU2021322239A1 (en) 2023-02-23
US20230279067A1 (en) 2023-09-07
BR112023002123A2 (pt) 2023-03-07
ZA202300862B (en) 2025-05-28
US11542308B2 (en) 2023-01-03
TW202221016A (zh) 2022-06-01
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CO2023001488A2 (es) 2023-02-16
AR123158A1 (es) 2022-11-02

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