JP7730336B2 - 同位体標識トラピジル誘導体 - Google Patents

同位体標識トラピジル誘導体

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Publication number
JP7730336B2
JP7730336B2 JP2022558003A JP2022558003A JP7730336B2 JP 7730336 B2 JP7730336 B2 JP 7730336B2 JP 2022558003 A JP2022558003 A JP 2022558003A JP 2022558003 A JP2022558003 A JP 2022558003A JP 7730336 B2 JP7730336 B2 JP 7730336B2
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JP
Japan
Prior art keywords
pharmaceutically acceptable
compound
solvate
acceptable salt
crystal
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2022558003A
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English (en)
Japanese (ja)
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JP2023519289A (ja
JP2023519289A5 (enExample
Inventor
ボードバー，アーラッシュ
マサムネ，ヒロコ
エス． ウェイド，ウォーレン
Original Assignee
シノピア バイオサイエンシーズ，インク．
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Application filed by シノピア バイオサイエンシーズ，インク． filed Critical シノピア バイオサイエンシーズ，インク．
Publication of JP2023519289A publication Critical patent/JP2023519289A/ja
Publication of JP2023519289A5 publication Critical patent/JP2023519289A5/ja
Priority to JP2025135217A priority Critical patent/JP2025183224A/ja
Application granted granted Critical
Publication of JP7730336B2 publication Critical patent/JP7730336B2/ja
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2022558003A 2020-03-26 2021-03-25 同位体標識トラピジル誘導体 Active JP7730336B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025135217A JP2025183224A (ja) 2020-03-26 2025-08-14 同位体標識トラピジル誘導体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063000347P 2020-03-26 2020-03-26
US63/000,347 2020-03-26
US202063063846P 2020-08-10 2020-08-10
US63/063,846 2020-08-10
PCT/US2021/024226 WO2021195425A1 (en) 2020-03-26 2021-03-25 Isotopically-labelled trapidil derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025135217A Division JP2025183224A (ja) 2020-03-26 2025-08-14 同位体標識トラピジル誘導体

Publications (3)

Publication Number Publication Date
JP2023519289A JP2023519289A (ja) 2023-05-10
JP2023519289A5 JP2023519289A5 (enExample) 2024-04-01
JP7730336B2 true JP7730336B2 (ja) 2025-08-27

Family

ID=77892379

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022558003A Active JP7730336B2 (ja) 2020-03-26 2021-03-25 同位体標識トラピジル誘導体
JP2025135217A Pending JP2025183224A (ja) 2020-03-26 2025-08-14 同位体標識トラピジル誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025135217A Pending JP2025183224A (ja) 2020-03-26 2025-08-14 同位体標識トラピジル誘導体

Country Status (10)

Country Link
US (1) US12508267B2 (enExample)
EP (1) EP4125853A4 (enExample)
JP (2) JP7730336B2 (enExample)
KR (1) KR20230013023A (enExample)
CN (3) CN115916180A (enExample)
AU (1) AU2021244241A1 (enExample)
CA (1) CA3177066A1 (enExample)
IL (1) IL296788A (enExample)
MX (1) MX2022011879A (enExample)
WO (1) WO2021195425A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017176652A2 (en) 2016-04-04 2017-10-12 Sinopia Biosciences, Inc. Treating extrapyramidal syndrome using trapidil
CN115916180A (zh) 2020-03-26 2023-04-04 希诺皮亚生物科学公司 同位素标记的曲匹地尔衍生物

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Also Published As

Publication number Publication date
CN115916180A (zh) 2023-04-04
CN116496279B (zh) 2025-12-12
IL296788A (en) 2022-11-01
US12508267B2 (en) 2025-12-30
JP2023519289A (ja) 2023-05-10
CN121550230A (zh) 2026-02-24
MX2022011879A (es) 2023-01-11
JP2025183224A (ja) 2025-12-16
AU2021244241A1 (en) 2022-11-24
CA3177066A1 (en) 2021-09-30
KR20230013023A (ko) 2023-01-26
US20230102580A1 (en) 2023-03-30
TW202202502A (zh) 2022-01-16
EP4125853A4 (en) 2024-07-03
EP4125853A1 (en) 2023-02-08
TW202547838A (zh) 2025-12-16
CN116496279A (zh) 2023-07-28
WO2021195425A1 (en) 2021-09-30

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