JP7672201B2 - Ｎａｓｈ／ｎａｆｌｄおよび関連疾患治療のための組合せ - Google Patents

Ｎａｓｈ／ｎａｆｌｄおよび関連疾患治療のための組合せ Download PDF

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JP7672201B2
JP7672201B2 JP2020087116A JP2020087116A JP7672201B2 JP 7672201 B2 JP7672201 B2 JP 7672201B2 JP 2020087116 A JP2020087116 A JP 2020087116A JP 2020087116 A JP2020087116 A JP 2020087116A JP 7672201 B2 JP7672201 B2 JP 7672201B2
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methyl
piperidin
carboxylic acid
benzimidazole
benzodioxol
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JP2020200308A5 (https=
JP2020200308A (ja
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ガリー・イー・アプネス
スコット・ダブリュー・バグリー
ジョン・エム・カート
マシュー・ダウリング
デビッド・ジェームズ・エドモンズ
ディリニー・フェルナンド
マーク・イー・フラナガン
建太郎 二木
デビッド・アンドリュー・グリフィス
キム・ウアード
ガジェンドラ・イングル
ウェンフア・ジャオ
ショーン・エム・ラカッセ
ヤジン・リアン
クリス・リンベラキス
アリン・ティー・ロンドレガン
アラン・エム・マシオウェツ
デビッド・ウォルター・ピオトロウスキー
ロジャー・ビー・ラッゲリ
クリスティン・ウィグレスワース
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ファイザー・インク
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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JP2020087116A 2019-05-20 2020-05-19 Ｎａｓｈ／ｎａｆｌｄおよび関連疾患治療のための組合せ Active JP7672201B2 (ja)

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US201962850133P 2019-05-20 2019-05-20
US62/850,133 2019-05-20

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JP2020200308A JP2020200308A (ja) 2020-12-17
JP2020200308A5 JP2020200308A5 (https=) 2023-03-23
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EP (2) EP4578460A3 (https=)
JP (1) JP7672201B2 (https=)
CN (1) CN113874019A (https=)
AR (1) AR118965A1 (https=)
CA (1) CA3140972C (https=)
ES (1) ES3039586T3 (https=)
TW (1) TW202110446A (https=)
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JP2022058085A (ja) * 2020-02-24 2022-04-11 ファイザー・インク ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ
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US20250066338A1 (en) 2021-12-16 2025-02-27 Astrazeneca Ab Certain 3-azabicyclo[3.1.0]hexanes as glp-1 receptor modulators
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CN119137124A (zh) 2022-03-09 2024-12-13 加舒布鲁姆生物公司 杂环glp-1激动剂
WO2023198140A1 (en) 2022-04-14 2023-10-19 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
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WO2024212742A1 (zh) * 2023-04-10 2024-10-17 上海研健新药研发有限公司 一种glp-1r激动剂，其制备方法和应用
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