TW202110446A - 用於治療ｎａｓｈ／ｎａｆｌｄ及相關疾病之組合 - Google Patents

用於治療ｎａｓｈ／ｎａｆｌｄ及相關疾病之組合 Download PDF

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TW202110446A
TW202110446A TW109116550A TW109116550A TW202110446A TW 202110446 A TW202110446 A TW 202110446A TW 109116550 A TW109116550 A TW 109116550A TW 109116550 A TW109116550 A TW 109116550A TW 202110446 A TW202110446 A TW 202110446A
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Taiwan
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methyl
carboxylic acid
benzimidazole
ylmethyl
benzodioxol
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TW109116550A
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Chinese (zh)
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蓋瑞 艾斯柏尼斯
史考特 貝格里
約翰 客托
馬修 道林
大衛 艾德蒙
迪林尼 法蘭度
馬克 佛蘭根
二木建太郎
大衛 格利菲斯
金 華德
加金德拉 英格
文化 焦
尚恩 拉柯賽
連亞靜
克里斯 林柏克斯
艾力 龍卓根
艾倫 馬西威茲
大衛 帕歐卓斯基
羅傑 羅格利
克里斯汀 威格勒
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美商輝瑞股份有限公司
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Publication of TW202110446A publication Critical patent/TW202110446A/zh

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K38/22—Hormones
    • A61K38/26—Glucagons
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    • A61K38/22—Hormones
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  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
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  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW109116550A 2019-05-20 2020-05-19 用於治療ｎａｓｈ／ｎａｆｌｄ及相關疾病之組合 TW202110446A (zh)

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US201962850133P 2019-05-20 2019-05-20
US62/850,133 2019-05-20

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US (1) US12611401B2 (https=)
EP (2) EP4578460A3 (https=)
JP (1) JP7672201B2 (https=)
CN (1) CN113874019A (https=)
AR (1) AR118965A1 (https=)
CA (1) CA3140972C (https=)
ES (1) ES3039586T3 (https=)
TW (1) TW202110446A (https=)
WO (1) WO2020234726A1 (https=)

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