JP7645801B2 - Ｃｄ３８に特異的な二環式ペプチドリガンド - Google Patents

Ｃｄ３８に特異的な二環式ペプチドリガンド Download PDF

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Publication number
JP7645801B2
JP7645801B2 JP2021540842A JP2021540842A JP7645801B2 JP 7645801 B2 JP7645801 B2 JP 7645801B2 JP 2021540842 A JP2021540842 A JP 2021540842A JP 2021540842 A JP2021540842 A JP 2021540842A JP 7645801 B2 JP7645801 B2 JP 7645801B2
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seq
referred
acid
peptide
peptide ligand
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JP2022517040A (ja
JP2022517040A5 (OSRAM
Inventor
バルダッサーレ レオナルド
ラニ ラシッド
パヴァン シルヴィア
ステイス キャサリン
トイフェル ダニエル
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BicycleTx Ltd
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BicycleTx Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2021540842A 2019-01-15 2020-01-15 Ｃｄ３８に特異的な二環式ペプチドリガンド Active JP7645801B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024185776A JP2025023938A (ja) 2019-01-15 2024-10-22 Ｃｄ３８に特異的な二環式ペプチドリガンド

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1900529.7A GB201900529D0 (en) 2019-01-15 2019-01-15 Bicyclic peptide ligands specific for CD38
GB1900529.7 2019-01-15
PCT/GB2020/050073 WO2020148529A1 (en) 2019-01-15 2020-01-15 Bicyclic peptide ligands specific for cd38

Related Child Applications (1)

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JP2024185776A Division JP2025023938A (ja) 2019-01-15 2024-10-22 Ｃｄ３８に特異的な二環式ペプチドリガンド

Publications (3)

Publication Number Publication Date
JP2022517040A JP2022517040A (ja) 2022-03-03
JP2022517040A5 JP2022517040A5 (OSRAM) 2023-01-25
JP7645801B2 true JP7645801B2 (ja) 2025-03-14

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JP2024185776A Pending JP2025023938A (ja) 2019-01-15 2024-10-22 Ｃｄ３８に特異的な二環式ペプチドリガンド

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Country Status (6)

Country Link
US (1) US12516084B2 (OSRAM)
EP (1) EP3911365A1 (OSRAM)
JP (2) JP7645801B2 (OSRAM)
CN (1) CN113543813B (OSRAM)
GB (1) GB201900529D0 (OSRAM)
WO (1) WO2020148529A1 (OSRAM)

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