JP7624404B2 - Ｐｒｃ２阻害剤としてのナフチリジン誘導体 - Google Patents

Ｐｒｃ２阻害剤としてのナフチリジン誘導体 Download PDF

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JP7624404B2
JP7624404B2 JP2021562339A JP2021562339A JP7624404B2 JP 7624404 B2 JP7624404 B2 JP 7624404B2 JP 2021562339 A JP2021562339 A JP 2021562339A JP 2021562339 A JP2021562339 A JP 2021562339A JP 7624404 B2 JP7624404 B2 JP 7624404B2
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mmol
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mixture
methyl
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ケチャム，ジョン，マイケル
バーンズ，アーロン，クレイグ
マルクス，マシュー，アーノルド
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ミラティ セラピューティクス，インク．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2021562339A 2019-04-22 2020-04-21 Ｐｒｃ２阻害剤としてのナフチリジン誘導体 Active JP7624404B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962836840P 2019-04-22 2019-04-22
US62/836,840 2019-04-22
PCT/US2020/029118 WO2020219448A1 (en) 2019-04-22 2020-04-21 Naphthyridine derivatives as prc2 inhibitors

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JP2022530866A JP2022530866A (ja) 2022-07-04
JP2022530866A5 JP2022530866A5 (https=) 2023-04-19
JP7624404B2 true JP7624404B2 (ja) 2025-01-30

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US (1) US12421228B2 (https=)
EP (1) EP3959214A1 (https=)
JP (1) JP7624404B2 (https=)
WO (1) WO2020219448A1 (https=)

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US12421228B2 (en) 2019-04-22 2025-09-23 Mirati Therapeutics, Inc. Naphthyridine derivatives as PRC2 inhibitors
EP3980422A1 (en) 2019-06-05 2022-04-13 Mirati Therapeutics, Inc. Imidazo[1,2-c]pyrimidine derivatives as prc2 inhibitors for treating cancer
WO2022184116A1 (zh) * 2021-03-05 2022-09-09 江苏先声药业有限公司 新型sos1抑制剂及其制备方法和应用
CN113861172B (zh) * 2021-09-23 2024-04-16 北京大学深圳研究生院 基于苯并五元杂环的双极性荧光材料及其制备方法与有机电致发光器件
EP4539840A4 (en) * 2022-06-17 2026-04-15 Sundance Biosciences Inc Kinase Modulators and Their Methods of Use
WO2025117697A1 (en) * 2023-11-29 2025-06-05 Riboscience Llc 7-aza bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors

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JP2022530866A (ja) 2022-07-04
US12421228B2 (en) 2025-09-23
US20220213097A1 (en) 2022-07-07
EP3959214A1 (en) 2022-03-02
WO2020219448A1 (en) 2020-10-29

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