JP7622338B2 - ２－（３，５－ジクロロフェニル）－６－ベンズオキサゾールカルボン酸１－デオキシ－１－メチルアミノ－ｄ－グルシトールの製造方法 - Google Patents

２－（３，５－ジクロロフェニル）－６－ベンズオキサゾールカルボン酸１－デオキシ－１－メチルアミノ－ｄ－グルシトールの製造方法 Download PDF

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JP7622338B2
JP7622338B2 JP2021560231A JP2021560231A JP7622338B2 JP 7622338 B2 JP7622338 B2 JP 7622338B2 JP 2021560231 A JP2021560231 A JP 2021560231A JP 2021560231 A JP2021560231 A JP 2021560231A JP 7622338 B2 JP7622338 B2 JP 7622338B2
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formula
compound
dichlorophenyl
benzoxazole
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JP2022526675A (ja
JP2022526675A5 (enExample
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セルジオ、ロドリゲス、ロペロ
フアン、ウゲット、クロテット
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Inke SA
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Inke SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2021560231A 2019-04-11 2020-03-19 ２－（３，５－ジクロロフェニル）－６－ベンズオキサゾールカルボン酸１－デオキシ－１－メチルアミノ－ｄ－グルシトールの製造方法 Active JP7622338B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19382273.1 2019-04-11
EP19382273 2019-04-11
PCT/EP2020/057683 WO2020207753A1 (en) 2019-04-11 2020-03-19 Process for preparing 1-deoxy-1-methylamino-d-glucitol 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylate

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JP2022526675A JP2022526675A (ja) 2022-05-25
JP2022526675A5 JP2022526675A5 (enExample) 2023-03-27
JP7622338B2 true JP7622338B2 (ja) 2025-01-28

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JP2021560231A Active JP7622338B2 (ja) 2019-04-11 2020-03-19 ２－（３，５－ジクロロフェニル）－６－ベンズオキサゾールカルボン酸１－デオキシ－１－メチルアミノ－ｄ－グルシトールの製造方法

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US (1) US12116352B2 (enExample)
EP (1) EP3953339B1 (enExample)
JP (1) JP7622338B2 (enExample)
CN (1) CN113874359B (enExample)
AR (1) AR118647A1 (enExample)
ES (1) ES2991081T3 (enExample)
HR (1) HRP20241374T1 (enExample)
HU (1) HUE068975T2 (enExample)
PL (1) PL3953339T3 (enExample)
WO (1) WO2020207753A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113372290A (zh) * 2021-05-21 2021-09-10 遵义医科大学 一种药物Tafamidis的合成方法
CN113277993B (zh) * 2021-06-06 2023-07-21 湖南第一师范学院 一种Tafamidis及其衍生物的合成方法
CN113735792B (zh) * 2021-09-22 2024-10-18 上海新礼泰药业有限公司 氯苯唑酸葡胺及其中间体的制备方法
KR102657823B1 (ko) * 2022-03-10 2024-04-16 고려대학교 산학협력단 타파미디스의 신규 합성법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006511612A (ja) 2002-12-19 2006-04-06 ザ スクリップス リサーチ インスティテュート トランスチレチンの安定化及びトランスチレチンの誤った折り畳みの阻害のための組成物及び方法
JP2006513250A (ja) 2003-01-28 2006-04-20 中国科学院上海薬物研究所 アラニン系化合物、その製造方法及び用途
JP2014526498A (ja) 2011-09-16 2014-10-06 ファイザー・インク トランスサイレチン解離阻害剤の固体形態

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9499527B2 (en) * 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of familial amyloid polyneuropathy
PT4349406T (pt) * 2014-09-08 2026-02-04 Pfizer Formas sólidas cristalinas de 6-carboxi-2-(3,5-diclorofenil)-benzoxazol para utilização como medicamento
CN107344927A (zh) 2016-05-05 2017-11-14 苏州晶云药物科技有限公司 Tafamidis葡甲胺盐的晶型E及其制备方法和用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006511612A (ja) 2002-12-19 2006-04-06 ザ スクリップス リサーチ インスティテュート トランスチレチンの安定化及びトランスチレチンの誤った折り畳みの阻害のための組成物及び方法
JP2006513250A (ja) 2003-01-28 2006-04-20 中国科学院上海薬物研究所 アラニン系化合物、その製造方法及び用途
JP2014526498A (ja) 2011-09-16 2014-10-06 ファイザー・インク トランスサイレチン解離阻害剤の固体形態

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Christine E. Bulawa et al.，Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade，Proceedings of the National Academy of Sciences，2012年，Vol.99, No.24，9629-9634，DOI: 10.1073/pnas.1121005109

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CN113874359B (zh) 2024-07-16
US20220144787A1 (en) 2022-05-12
US12116352B2 (en) 2024-10-15
CN113874359A (zh) 2021-12-31
EP3953339A1 (en) 2022-02-16
EP3953339C0 (en) 2024-09-04
PL3953339T3 (pl) 2025-05-05
JP2022526675A (ja) 2022-05-25
ES2991081T3 (es) 2024-12-02
AR118647A1 (es) 2021-10-20
EP3953339B1 (en) 2024-09-04
HRP20241374T1 (hr) 2024-12-20
HUE068975T2 (hu) 2025-02-28
WO2020207753A1 (en) 2020-10-15

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