HRP20241374T1 - Postupak priprave 1-deoksi-1-metilamino-d-glucitol-2-(3,5-diklorfenil)-6-benzoksazolkarboksilata - Google Patents
Postupak priprave 1-deoksi-1-metilamino-d-glucitol-2-(3,5-diklorfenil)-6-benzoksazolkarboksilata Download PDFInfo
- Publication number
- HRP20241374T1 HRP20241374T1 HRP20241374TT HRP20241374T HRP20241374T1 HR P20241374 T1 HRP20241374 T1 HR P20241374T1 HR P20241374T T HRP20241374T T HR P20241374TT HR P20241374 T HRP20241374 T HR P20241374T HR P20241374 T1 HRP20241374 T1 HR P20241374T1
- Authority
- HR
- Croatia
- Prior art keywords
- formula
- vol
- compound
- dichlorophenyl
- image
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 19
- LYMYCWASYRWFBQ-QXCFHYIPSA-N ClC=1C=C(C=C(C=1)Cl)C=1OC2=C(N=1)C=CC(=C2)C(=O)O[C@@H](CNC)[C@@H](O)[C@H](O)[C@H](O)CO Chemical compound ClC=1C=C(C=C(C=1)Cl)C=1OC2=C(N=1)C=CC(=C2)C(=O)O[C@@H](CNC)[C@@H](O)[C@H](O)[C@H](O)CO LYMYCWASYRWFBQ-QXCFHYIPSA-N 0.000 title claims 7
- 238000002360 preparation method Methods 0.000 title claims 4
- 150000001875 compounds Chemical class 0.000 claims 9
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 229910052708 sodium Inorganic materials 0.000 claims 6
- 239000011734 sodium Substances 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 5
- 239000002904 solvent Substances 0.000 claims 5
- 239000011877 solvent mixture Substances 0.000 claims 5
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 150000007529 inorganic bases Chemical class 0.000 claims 3
- 229910052700 potassium Inorganic materials 0.000 claims 3
- 239000011591 potassium Substances 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 2
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 claims 1
- 150000008041 alkali metal carbonates Chemical class 0.000 claims 1
- 239000008346 aqueous phase Substances 0.000 claims 1
- 238000005266 casting Methods 0.000 claims 1
- 150000001805 chlorine compounds Chemical group 0.000 claims 1
- 238000004821 distillation Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
- 229940071870 hydroiodic acid Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000011736 potassium bicarbonate Substances 0.000 claims 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims 1
- 235000015497 potassium bicarbonate Nutrition 0.000 claims 1
- 229910000027 potassium carbonate Inorganic materials 0.000 claims 1
- 235000011181 potassium carbonates Nutrition 0.000 claims 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 1
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 1
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 1
- 235000017550 sodium carbonate Nutrition 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19382273 | 2019-04-11 | ||
| PCT/EP2020/057683 WO2020207753A1 (en) | 2019-04-11 | 2020-03-19 | Process for preparing 1-deoxy-1-methylamino-d-glucitol 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylate |
| EP20710987.7A EP3953339B1 (en) | 2019-04-11 | 2020-03-19 | Process for preparing 1-deoxy-1-methylamino-d-glucitol 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20241374T1 true HRP20241374T1 (hr) | 2024-12-20 |
Family
ID=66240025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20241374TT HRP20241374T1 (hr) | 2019-04-11 | 2020-03-19 | Postupak priprave 1-deoksi-1-metilamino-d-glucitol-2-(3,5-diklorfenil)-6-benzoksazolkarboksilata |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12116352B2 (enExample) |
| EP (1) | EP3953339B1 (enExample) |
| JP (1) | JP7622338B2 (enExample) |
| CN (1) | CN113874359B (enExample) |
| AR (1) | AR118647A1 (enExample) |
| ES (1) | ES2991081T3 (enExample) |
| HR (1) | HRP20241374T1 (enExample) |
| HU (1) | HUE068975T2 (enExample) |
| PL (1) | PL3953339T3 (enExample) |
| WO (1) | WO2020207753A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113372290A (zh) * | 2021-05-21 | 2021-09-10 | 遵义医科大学 | 一种药物Tafamidis的合成方法 |
| CN113277993B (zh) * | 2021-06-06 | 2023-07-21 | 湖南第一师范学院 | 一种Tafamidis及其衍生物的合成方法 |
| CN113735792B (zh) * | 2021-09-22 | 2024-10-18 | 上海新礼泰药业有限公司 | 氯苯唑酸葡胺及其中间体的制备方法 |
| KR102657823B1 (ko) * | 2022-03-10 | 2024-04-16 | 고려대학교 산학협력단 | 타파미디스의 신규 합성법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2800237C (en) * | 2002-12-19 | 2016-05-17 | The Scripps Research Institute | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding |
| JP2006513250A (ja) | 2003-01-28 | 2006-04-20 | 中国科学院上海薬物研究所 | アラニン系化合物、その製造方法及び用途 |
| RU2586330C2 (ru) | 2011-09-16 | 2016-06-10 | Пфайзер Инк. | Твердые формы ингибитора диссоциации транстиретина |
| US9499527B2 (en) * | 2012-05-10 | 2016-11-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of familial amyloid polyneuropathy |
| PT4349406T (pt) * | 2014-09-08 | 2026-02-04 | Pfizer | Formas sólidas cristalinas de 6-carboxi-2-(3,5-diclorofenil)-benzoxazol para utilização como medicamento |
| CN107344927A (zh) | 2016-05-05 | 2017-11-14 | 苏州晶云药物科技有限公司 | Tafamidis葡甲胺盐的晶型E及其制备方法和用途 |
-
2020
- 2020-03-19 US US17/601,946 patent/US12116352B2/en active Active
- 2020-03-19 ES ES20710987T patent/ES2991081T3/es active Active
- 2020-03-19 HU HUE20710987A patent/HUE068975T2/hu unknown
- 2020-03-19 JP JP2021560231A patent/JP7622338B2/ja active Active
- 2020-03-19 WO PCT/EP2020/057683 patent/WO2020207753A1/en not_active Ceased
- 2020-03-19 HR HRP20241374TT patent/HRP20241374T1/hr unknown
- 2020-03-19 CN CN202080035225.4A patent/CN113874359B/zh active Active
- 2020-03-19 PL PL20710987.7T patent/PL3953339T3/pl unknown
- 2020-03-19 EP EP20710987.7A patent/EP3953339B1/en active Active
- 2020-04-09 AR ARP200101020A patent/AR118647A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN113874359B (zh) | 2024-07-16 |
| US20220144787A1 (en) | 2022-05-12 |
| US12116352B2 (en) | 2024-10-15 |
| CN113874359A (zh) | 2021-12-31 |
| EP3953339A1 (en) | 2022-02-16 |
| EP3953339C0 (en) | 2024-09-04 |
| PL3953339T3 (pl) | 2025-05-05 |
| JP2022526675A (ja) | 2022-05-25 |
| ES2991081T3 (es) | 2024-12-02 |
| AR118647A1 (es) | 2021-10-20 |
| EP3953339B1 (en) | 2024-09-04 |
| JP7622338B2 (ja) | 2025-01-28 |
| HUE068975T2 (hu) | 2025-02-28 |
| WO2020207753A1 (en) | 2020-10-15 |
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