CN113874359B - 用于制备1-脱氧-1-甲基氨基-d-葡萄糖醇2-(3,5-二氯苯基)-6-苯并𫫇唑羧酸盐的方法 - Google Patents
用于制备1-脱氧-1-甲基氨基-d-葡萄糖醇2-(3,5-二氯苯基)-6-苯并𫫇唑羧酸盐的方法 Download PDFInfo
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- CN113874359B CN113874359B CN202080035225.4A CN202080035225A CN113874359B CN 113874359 B CN113874359 B CN 113874359B CN 202080035225 A CN202080035225 A CN 202080035225A CN 113874359 B CN113874359 B CN 113874359B
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- compound
- formula
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- dichlorophenyl
- benzo
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19382273.1 | 2019-04-11 | ||
| EP19382273 | 2019-04-11 | ||
| PCT/EP2020/057683 WO2020207753A1 (en) | 2019-04-11 | 2020-03-19 | Process for preparing 1-deoxy-1-methylamino-d-glucitol 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113874359A CN113874359A (zh) | 2021-12-31 |
| CN113874359B true CN113874359B (zh) | 2024-07-16 |
Family
ID=66240025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080035225.4A Active CN113874359B (zh) | 2019-04-11 | 2020-03-19 | 用于制备1-脱氧-1-甲基氨基-d-葡萄糖醇2-(3,5-二氯苯基)-6-苯并𫫇唑羧酸盐的方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12116352B2 (enExample) |
| EP (1) | EP3953339B1 (enExample) |
| JP (1) | JP7622338B2 (enExample) |
| CN (1) | CN113874359B (enExample) |
| AR (1) | AR118647A1 (enExample) |
| ES (1) | ES2991081T3 (enExample) |
| HR (1) | HRP20241374T1 (enExample) |
| HU (1) | HUE068975T2 (enExample) |
| PL (1) | PL3953339T3 (enExample) |
| WO (1) | WO2020207753A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113372290A (zh) * | 2021-05-21 | 2021-09-10 | 遵义医科大学 | 一种药物Tafamidis的合成方法 |
| CN113277993B (zh) * | 2021-06-06 | 2023-07-21 | 湖南第一师范学院 | 一种Tafamidis及其衍生物的合成方法 |
| CN113735792B (zh) * | 2021-09-22 | 2024-10-18 | 上海新礼泰药业有限公司 | 氯苯唑酸葡胺及其中间体的制备方法 |
| KR102657823B1 (ko) * | 2022-03-10 | 2024-04-16 | 고려대학교 산학협력단 | 타파미디스의 신규 합성법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2800237C (en) * | 2002-12-19 | 2016-05-17 | The Scripps Research Institute | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding |
| JP2006513250A (ja) | 2003-01-28 | 2006-04-20 | 中国科学院上海薬物研究所 | アラニン系化合物、その製造方法及び用途 |
| RU2586330C2 (ru) | 2011-09-16 | 2016-06-10 | Пфайзер Инк. | Твердые формы ингибитора диссоциации транстиретина |
| US9499527B2 (en) * | 2012-05-10 | 2016-11-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of familial amyloid polyneuropathy |
| PT4349406T (pt) * | 2014-09-08 | 2026-02-04 | Pfizer | Formas sólidas cristalinas de 6-carboxi-2-(3,5-diclorofenil)-benzoxazol para utilização como medicamento |
| CN107344927A (zh) | 2016-05-05 | 2017-11-14 | 苏州晶云药物科技有限公司 | Tafamidis葡甲胺盐的晶型E及其制备方法和用途 |
-
2020
- 2020-03-19 US US17/601,946 patent/US12116352B2/en active Active
- 2020-03-19 ES ES20710987T patent/ES2991081T3/es active Active
- 2020-03-19 HU HUE20710987A patent/HUE068975T2/hu unknown
- 2020-03-19 JP JP2021560231A patent/JP7622338B2/ja active Active
- 2020-03-19 WO PCT/EP2020/057683 patent/WO2020207753A1/en not_active Ceased
- 2020-03-19 HR HRP20241374TT patent/HRP20241374T1/hr unknown
- 2020-03-19 CN CN202080035225.4A patent/CN113874359B/zh active Active
- 2020-03-19 PL PL20710987.7T patent/PL3953339T3/pl unknown
- 2020-03-19 EP EP20710987.7A patent/EP3953339B1/en active Active
- 2020-04-09 AR ARP200101020A patent/AR118647A1/es unknown
Non-Patent Citations (1)
| Title |
|---|
| Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade;Christine E. Bulawa et al.;《PNAS》;第109卷(第24期);9629-9634 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20220144787A1 (en) | 2022-05-12 |
| US12116352B2 (en) | 2024-10-15 |
| CN113874359A (zh) | 2021-12-31 |
| EP3953339A1 (en) | 2022-02-16 |
| EP3953339C0 (en) | 2024-09-04 |
| PL3953339T3 (pl) | 2025-05-05 |
| JP2022526675A (ja) | 2022-05-25 |
| ES2991081T3 (es) | 2024-12-02 |
| AR118647A1 (es) | 2021-10-20 |
| EP3953339B1 (en) | 2024-09-04 |
| HRP20241374T1 (hr) | 2024-12-20 |
| JP7622338B2 (ja) | 2025-01-28 |
| HUE068975T2 (hu) | 2025-02-28 |
| WO2020207753A1 (en) | 2020-10-15 |
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