JP7617134B2 - Gpr52アゴニスト活性を有する置換3-フェノキシアゼチジン-1-イル-ピラジン - Google Patents

Gpr52アゴニスト活性を有する置換3-フェノキシアゼチジン-1-イル-ピラジン Download PDF

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JP7617134B2
JP7617134B2 JP2022559709A JP2022559709A JP7617134B2 JP 7617134 B2 JP7617134 B2 JP 7617134B2 JP 2022559709 A JP2022559709 A JP 2022559709A JP 2022559709 A JP2022559709 A JP 2022559709A JP 7617134 B2 JP7617134 B2 JP 7617134B2
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JP2023522307A5 (https=
JP2023522307A (ja
Inventor
カイ ゲルラッハ
バルバラ ベルターニ
マルコ フェッラーラ
ジャコモ フォッサティ
スコット ホブソン
ウータ フリーデリーケ レッセル
フランク ルンゲ
グレイム センプレ
ウルズラ ミュラー-ヴィエイラ
ユリアン ウィッピッチ
イフェン ション
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ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
アリーナ ファーマシューティカルズ, インコーポレイテッド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2022559709A 2020-03-30 2021-03-29 Gpr52アゴニスト活性を有する置換3-フェノキシアゼチジン-1-イル-ピラジン Active JP7617134B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063001640P 2020-03-30 2020-03-30
US63/001,640 2020-03-30
PCT/EP2021/058099 WO2021198149A1 (en) 2020-03-30 2021-03-29 Substituted 3-phenoxyazetidin-1-yl-pyrazines having gpr52 agonistic activity

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JP2023522307A JP2023522307A (ja) 2023-05-30
JP2023522307A5 JP2023522307A5 (https=) 2024-05-23
JP7617134B2 true JP7617134B2 (ja) 2025-01-17

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JP2022559709A Active JP7617134B2 (ja) 2020-03-30 2021-03-29 Gpr52アゴニスト活性を有する置換3-フェノキシアゼチジン-1-イル-ピラジン

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US (1) US11780827B2 (https=)
EP (1) EP4126850B1 (https=)
JP (1) JP7617134B2 (https=)
KR (1) KR20220161454A (https=)
CN (1) CN115697997B (https=)
AR (1) AR121675A1 (https=)
AU (1) AU2021250303A1 (https=)
BR (1) BR112022018996A2 (https=)
CA (1) CA3176265A1 (https=)
CO (1) CO2022014886A2 (https=)
CR (1) CR20220554A (https=)
DO (1) DOP2022000203A (https=)
EC (1) ECSP22080683A (https=)
IL (1) IL296823A (https=)
JO (1) JOP20220235A1 (https=)
MX (1) MX2022012067A (https=)
PE (1) PE20221918A1 (https=)
PH (1) PH12022552553A1 (https=)
TW (1) TW202204343A (https=)
WO (1) WO2021198149A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202206413A (zh) 2020-04-22 2022-02-16 美商紐羅克里生物科學有限公司 Gpr52調節劑及其使用方法
US12115157B2 (en) 2021-09-14 2024-10-15 Boehringer Ingelheim International Gmbh 3-phenoxyazetidin-1-yl-heteroaryl pyrrolidine derivatives and the use thereof as medicament
CN119143731B (zh) * 2024-09-13 2025-08-26 中国海洋大学 一种吡嗪酰胺类化合物及其制备方法和应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002533454A (ja) 1998-12-23 2002-10-08 イーライ・リリー・アンド・カンパニー 芳香族アミド類
WO2009107391A1 (ja) 2008-02-27 2009-09-03 武田薬品工業株式会社 6員芳香環含有化合物
WO2011093352A1 (ja) 2010-01-27 2011-08-04 武田薬品工業株式会社 チアゾール誘導体
WO2011145735A1 (ja) 2010-05-21 2011-11-24 武田薬品工業株式会社 チアゾール誘導体
WO2012020738A1 (ja) 2010-08-09 2012-02-16 武田薬品工業株式会社 複素環化合物およびその用途
WO2012076063A1 (en) 2010-12-10 2012-06-14 Rottapharm S.P.A. Pyridine amide derivatives as ep4 receptor antagonists
JP2018519253A (ja) 2015-04-29 2018-07-19 アリーナ ファーマシューティカルズ, インコーポレイテッド Gpr52に関連する障害の治療または予防に有用なgpr52のモジュレーターとしての1−ヘテロアリール−インドリン−4−カルボキサミド

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0808668D0 (en) * 2008-05-13 2008-06-18 Univ Aberdeen Materials and methods relating to a G-protein coupled receptor
JPWO2009157196A1 (ja) 2008-06-25 2011-12-08 武田薬品工業株式会社 アミド化合物
WO2011078360A1 (ja) * 2009-12-24 2011-06-30 武田薬品工業株式会社 アミド化合物
AU2016324317A1 (en) * 2015-09-17 2018-03-08 Coda Biotherapeutics, Inc. Compositions and methods for treating neurological disorders

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002533454A (ja) 1998-12-23 2002-10-08 イーライ・リリー・アンド・カンパニー 芳香族アミド類
WO2009107391A1 (ja) 2008-02-27 2009-09-03 武田薬品工業株式会社 6員芳香環含有化合物
WO2011093352A1 (ja) 2010-01-27 2011-08-04 武田薬品工業株式会社 チアゾール誘導体
WO2011145735A1 (ja) 2010-05-21 2011-11-24 武田薬品工業株式会社 チアゾール誘導体
WO2012020738A1 (ja) 2010-08-09 2012-02-16 武田薬品工業株式会社 複素環化合物およびその用途
WO2012076063A1 (en) 2010-12-10 2012-06-14 Rottapharm S.P.A. Pyridine amide derivatives as ep4 receptor antagonists
JP2018519253A (ja) 2015-04-29 2018-07-19 アリーナ ファーマシューティカルズ, インコーポレイテッド Gpr52に関連する障害の治療または予防に有用なgpr52のモジュレーターとしての1−ヘテロアリール−インドリン−4−カルボキサミド

Also Published As

Publication number Publication date
CA3176265A1 (en) 2021-10-07
EP4126850B1 (en) 2024-04-17
CN115697997A (zh) 2023-02-03
PH12022552553A1 (en) 2024-01-03
MX2022012067A (es) 2022-10-13
DOP2022000203A (es) 2022-11-30
IL296823A (en) 2022-11-01
US20220356172A1 (en) 2022-11-10
CR20220554A (es) 2023-01-09
KR20220161454A (ko) 2022-12-06
WO2021198149A1 (en) 2021-10-07
JOP20220235A1 (ar) 2022-09-28
US11780827B2 (en) 2023-10-10
EP4126850A1 (en) 2023-02-08
AU2021250303A1 (en) 2022-09-22
BR112022018996A2 (pt) 2022-11-01
CO2022014886A2 (es) 2022-10-31
ECSP22080683A (es) 2022-11-30
AR121675A1 (es) 2022-06-29
CN115697997B (zh) 2024-07-30
TW202204343A (zh) 2022-02-01
PE20221918A1 (es) 2022-12-29
JP2023522307A (ja) 2023-05-30

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