PE20221918A1 - 3-fenoxiazetidin-1-il-pirazinas sustituidas que tienen actividad agonista de gpr52 - Google Patents

3-fenoxiazetidin-1-il-pirazinas sustituidas que tienen actividad agonista de gpr52

Info

Publication number
PE20221918A1
PE20221918A1 PE2022002146A PE2022002146A PE20221918A1 PE 20221918 A1 PE20221918 A1 PE 20221918A1 PE 2022002146 A PE2022002146 A PE 2022002146A PE 2022002146 A PE2022002146 A PE 2022002146A PE 20221918 A1 PE20221918 A1 PE 20221918A1
Authority
PE
Peru
Prior art keywords
group
pyrazines
gpr52
phenoxiazetidin
substituted
Prior art date
Application number
PE2022002146A
Other languages
English (en)
Inventor
Kai Gerlach
Barbara Bertani
Marco Ferrara
Giacomo Fossati
Scott Hobson
Uta Friederike Lessel
Frank Runge
Graeme Semple
Ursula Mueller-Vieira
Julian Wippich
Yifeng Xiong
Original Assignee
Boehringer Ingelheim Int
Arena Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int, Arena Pharm Inc filed Critical Boehringer Ingelheim Int
Publication of PE20221918A1 publication Critical patent/PE20221918A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invencion se refiere a compuestos derivados de 3-fenoxiazetidin-1-il-pirazinas de la formula general (I) que son agonistas de GPR52, utiles en el tratamiento de enfermedades del sistema nervioso central y otras enfermedades, donde: A es a) o b); R1 es R1a que consiste en H o F; R2 se selecciona del grupo R2a que consiste en H y F; R3 se selecciona del grupo R3a que consiste en lo siguiente halogeno, F2HCO, F3CO, F2HC y F3C; R4 se selecciona del grupo R4a que consiste en lo siguiente H y alquilo C1-3; el grupo alquilo C1-3 mencionado anteriormente puede estar opcionalmente sustituido con 1 a 5 sustituyentes seleccionados independientemente del grupo que consiste en fluor; o una sal de este.
PE2022002146A 2020-03-30 2021-03-29 3-fenoxiazetidin-1-il-pirazinas sustituidas que tienen actividad agonista de gpr52 PE20221918A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063001640P 2020-03-30 2020-03-30
PCT/EP2021/058099 WO2021198149A1 (en) 2020-03-30 2021-03-29 Substituted 3-phenoxyazetidin-1-yl-pyrazines having gpr52 agonistic activity

Publications (1)

Publication Number Publication Date
PE20221918A1 true PE20221918A1 (es) 2022-12-29

Family

ID=75362607

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2022002146A PE20221918A1 (es) 2020-03-30 2021-03-29 3-fenoxiazetidin-1-il-pirazinas sustituidas que tienen actividad agonista de gpr52

Country Status (18)

Country Link
US (1) US11780827B2 (es)
EP (1) EP4126850B1 (es)
JP (1) JP2023522307A (es)
KR (1) KR20220161454A (es)
CN (1) CN115697997A (es)
AR (1) AR121675A1 (es)
AU (1) AU2021250303A1 (es)
BR (1) BR112022018996A2 (es)
CA (1) CA3176265A1 (es)
CO (1) CO2022014886A2 (es)
CR (1) CR20220554A (es)
DO (1) DOP2022000203A (es)
EC (1) ECSP22080683A (es)
IL (1) IL296823A (es)
MX (1) MX2022012067A (es)
PE (1) PE20221918A1 (es)
TW (1) TW202204343A (es)
WO (1) WO2021198149A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230131465A1 (en) 2021-09-14 2023-04-27 Boehringer Ingelheim International Gmbh 3-phenoxyazetidin-1-yl-heteroaryl pyrrolidine derivatives and the use thereof as medicament

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2009107391A1 (ja) 2008-02-27 2011-06-30 武田薬品工業株式会社 ６員芳香環含有化合物
GB0808668D0 (en) * 2008-05-13 2008-06-18 Univ Aberdeen Materials and methods relating to a G-protein coupled receptor
EP2298731A4 (en) 2008-06-25 2011-09-21 Takeda Pharmaceutical AMIDE COMPOUND
WO2011078360A1 (ja) * 2009-12-24 2011-06-30 武田薬品工業株式会社 アミド化合物
WO2011093352A1 (ja) 2010-01-27 2011-08-04 武田薬品工業株式会社 チアゾール誘導体
WO2011145735A1 (ja) 2010-05-21 2011-11-24 武田薬品工業株式会社 チアゾール誘導体
WO2012020738A1 (ja) 2010-08-09 2012-02-16 武田薬品工業株式会社 複素環化合物およびその用途
EA034244B1 (ru) 2015-04-29 2020-01-21 Арена Фармасьютикалз, Инк. 1-гетероарил-индолин-4-карбоксамиды в качестве модуляторов gpr52, применяемые для лечения или предотвращения расстройств, связанных с gpr52
CN108348528A (zh) * 2015-09-17 2018-07-31 科达生物治疗公司 治疗神经障碍的组合物和方法

Also Published As

Publication number Publication date
EP4126850A1 (en) 2023-02-08
ECSP22080683A (es) 2022-11-30
US20220356172A1 (en) 2022-11-10
CN115697997A (zh) 2023-02-03
CR20220554A (es) 2023-01-09
WO2021198149A1 (en) 2021-10-07
CO2022014886A2 (es) 2022-10-31
CA3176265A1 (en) 2021-10-07
MX2022012067A (es) 2022-10-13
IL296823A (en) 2022-11-01
EP4126850B1 (en) 2024-04-17
BR112022018996A2 (pt) 2022-11-01
AU2021250303A1 (en) 2022-09-22
US11780827B2 (en) 2023-10-10
AR121675A1 (es) 2022-06-29
KR20220161454A (ko) 2022-12-06
TW202204343A (zh) 2022-02-01
JP2023522307A (ja) 2023-05-30
DOP2022000203A (es) 2022-11-30

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