BR112019005542A2 - composições para compostos de agente terapêutico de pequenas moléculas - Google Patents
composições para compostos de agente terapêutico de pequenas moléculasInfo
- Publication number
- BR112019005542A2 BR112019005542A2 BR112019005542A BR112019005542A BR112019005542A2 BR 112019005542 A2 BR112019005542 A2 BR 112019005542A2 BR 112019005542 A BR112019005542 A BR 112019005542A BR 112019005542 A BR112019005542 A BR 112019005542A BR 112019005542 A2 BR112019005542 A2 BR 112019005542A2
- Authority
- BR
- Brazil
- Prior art keywords
- therapeutic agent
- small molecule
- molecule therapeutic
- organic acid
- compositions
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 5
- 150000003384 small molecules Chemical class 0.000 title abstract 5
- 229940124597 therapeutic agent Drugs 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title 1
- 150000007524 organic acids Chemical class 0.000 abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
a presente invenção refere-se a uma composição que compreende uma suspensão aquosa compreendendo um agente terapêutico de pequenas moléculas e um ácido orgânico. o agente terapêutico de pequenas moléculas é uma base e possui uma solubilidade em água na temperatura ambiente menor do que cerca de 1,0 g/l. o ácido orgânico possui uma solubilidade em água na temperatura ambiente entre 0,1 e 10, possui uma massa molar menor do que 500 gramas por mol e/ou mantém um ph da suspensão em seu ambiente de uso entre 3,0 a 6,5. o ácido orgânico aumenta a solubilidade do agente terapêutico de pequenas moléculas e quando presente com excesso estequiométrico, o ácido orgânico aciona a liberação do agente terapêutico de pequenas moléculas em um ambiente de uso tamponado durante períodos prolongados, por exemplo, de seis meses a um ano. os dispositivos que compreendem as composições e métodos de tratamento também são descritos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662399083P | 2016-09-23 | 2016-09-23 | |
PCT/US2017/053074 WO2018057968A1 (en) | 2016-09-23 | 2017-09-22 | Compositions for small molecule therapeutic agent compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112019005542A2 true BR112019005542A2 (pt) | 2019-06-18 |
Family
ID=60083440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019005542A BR112019005542A2 (pt) | 2016-09-23 | 2017-09-22 | composições para compostos de agente terapêutico de pequenas moléculas |
Country Status (10)
Country | Link |
---|---|
US (1) | US20190224322A1 (pt) |
EP (1) | EP3515407A1 (pt) |
JP (2) | JP2019529564A (pt) |
KR (2) | KR20230093349A (pt) |
CN (1) | CN109890365A (pt) |
AU (1) | AU2017331340B2 (pt) |
BR (1) | BR112019005542A2 (pt) |
CA (1) | CA3037531A1 (pt) |
MX (2) | MX2019003052A (pt) |
WO (1) | WO2018057968A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2019228497A1 (en) * | 2018-02-27 | 2020-09-17 | Delpor, Inc. | Compositions for small molecule therapeutic agent compounds |
CA3149545A1 (en) * | 2019-08-28 | 2021-03-04 | Delpor, Inc. | Compositions for small molecule therapeutic agent compounds |
WO2022176017A1 (ja) * | 2021-02-16 | 2022-08-25 | 大塚製薬株式会社 | 非晶質体及び当該非晶質体を含む組成物 |
TWI820673B (zh) * | 2021-04-13 | 2023-11-01 | 大陸商上海雲晟研新生物科技有限公司 | 布瑞哌唑口溶膜組合物、其製備方法及用途 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5453425A (en) * | 1994-07-11 | 1995-09-26 | Janssen Pharmaceutica N.V. | Risperidone oral formulation |
US7592300B2 (en) * | 2003-11-24 | 2009-09-22 | The Dial Corporation | Antimicrobial compositions containing an aromatic carboxylic acid and a hydric solvent |
AR048272A1 (es) * | 2004-03-18 | 2006-04-12 | Lek Pharmaceuticals | Sintesis de 2 metil - 4- (4- metil -1- piperazinil) - 10 h- tieno ( 2,3-b) (1,5) benzodiazepina y sus sales, metodos para su preparacion, composiciones farmaceuticas que la contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mentales. |
PL377084A1 (pl) * | 2005-09-15 | 2007-03-19 | Koźluk Tomasz Nobilus Ent | Nowe związki olanzapiny i sposób ich wytwarzania |
NZ584370A (en) * | 2007-10-09 | 2011-04-29 | Cipla Ltd | Processes for the preparation of paliperidone and pharmaceutically acceptable salts thereof and intermediates for use in the processes |
WO2009135091A1 (en) * | 2008-04-30 | 2009-11-05 | Medivation Technologies, Inc. | Use of asenapine and related compounds for the treatment of neuronal or non-neuronal diseases or conditions |
EP3006024B1 (en) * | 2009-01-20 | 2019-03-20 | Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center | Benzoic acid or salts thereof to enhance the activity of a neuropharmaceutical |
US9561352B2 (en) | 2009-03-12 | 2017-02-07 | Delpor, Inc. | Implantable device for long-term delivery of drugs |
JP5664871B2 (ja) * | 2009-06-19 | 2015-02-04 | 株式会社 メドレックス | アリピプラゾールと有機酸を有効成分とする外用剤組成物 |
HRP20211853T1 (hr) * | 2010-05-31 | 2022-03-04 | Laboratorios Farmaceuticos Rovi, S.A. | Sastavi in situ injekcijskih biorazgradivih implantata |
KR101408370B1 (ko) * | 2012-06-26 | 2014-06-18 | 주식회사지씨비 | 아리피프라졸-유기산 공결정을 함유하는 제제 및 이의 제조 방법 |
CA2885941A1 (en) * | 2012-09-28 | 2014-04-03 | Delpor, Inc. | Device and method for sustained release of antipsychotic medications |
CN106474058B (zh) * | 2015-08-31 | 2020-01-07 | 南京诺瑞特医药科技有限公司 | 具有延长的保质期的阿立哌唑可注射悬浮液制剂 |
-
2017
- 2017-09-22 BR BR112019005542A patent/BR112019005542A2/pt active Search and Examination
- 2017-09-22 AU AU2017331340A patent/AU2017331340B2/en active Active
- 2017-09-22 EP EP17784087.3A patent/EP3515407A1/en active Pending
- 2017-09-22 KR KR1020237019611A patent/KR20230093349A/ko not_active Application Discontinuation
- 2017-09-22 CA CA3037531A patent/CA3037531A1/en active Pending
- 2017-09-22 MX MX2019003052A patent/MX2019003052A/es unknown
- 2017-09-22 KR KR1020197011224A patent/KR20190066608A/ko not_active IP Right Cessation
- 2017-09-22 WO PCT/US2017/053074 patent/WO2018057968A1/en unknown
- 2017-09-22 CN CN201780065098.0A patent/CN109890365A/zh active Pending
- 2017-09-22 US US16/336,088 patent/US20190224322A1/en active Pending
- 2017-09-22 JP JP2019537753A patent/JP2019529564A/ja active Pending
-
2019
- 2019-03-15 MX MX2023003010A patent/MX2023003010A/es unknown
-
2022
- 2022-09-09 JP JP2022144103A patent/JP2022188046A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20230093349A (ko) | 2023-06-27 |
MX2019003052A (es) | 2019-11-25 |
MX2023003010A (es) | 2023-04-10 |
CN109890365A (zh) | 2019-06-14 |
CA3037531A1 (en) | 2018-03-29 |
US20190224322A1 (en) | 2019-07-25 |
KR20190066608A (ko) | 2019-06-13 |
JP2022188046A (ja) | 2022-12-20 |
AU2017331340A1 (en) | 2019-04-11 |
AU2017331340B2 (en) | 2023-09-28 |
EP3515407A1 (en) | 2019-07-31 |
WO2018057968A1 (en) | 2018-03-29 |
JP2019529564A (ja) | 2019-10-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112019005542A2 (pt) | composições para compostos de agente terapêutico de pequenas moléculas | |
BR112015025766A2 (pt) | derivado de nucleosídeo altamente ativo para o tratamento de hcv | |
BR112019024785A2 (pt) | composto de bifenila ou sal do mesmo, composição farmacêutica, agente antineoplásico e uso | |
BR112014025564A2 (pt) | composto heterocíclico contendo nitrogênio ou sal do mesmo | |
BR112014009131A2 (pt) | formulações de etanercept estabilizadas com meglumina | |
BR112018014272A2 (pt) | processo de preparação de etilenoaminas | |
CL2019002677A1 (es) | Composición adhesiva y método de preparación de la misma. | |
BR112013010918B8 (pt) | composição compreendendo sal de cloridrato de alumínio, método de fabricação do referido sal e usos do mesmo | |
BR112022010112A2 (pt) | Aminoquinolonas substituídas como inibidores de dgkalfa para ativação imunológica | |
PH12015502802A1 (en) | Formulation comprising a hypolipidemic agent | |
BR112015023829A2 (pt) | composto de amidina e seu uso | |
BR112018013033A2 (pt) | compostos de indolinonas e seu uso no tratamentod de doenças fibróticas | |
BR112016025126A2 (pt) | formulação líquida compreendendo composto neutralizante de gm-csf | |
BR112012026659A2 (pt) | composto para desinfecção de superfícies. | |
BR112015026967A8 (pt) | fenoxietil di-hidro-1h-isoquinolina, seus usos, e composição farmacêutica | |
NI202000031A (es) | Novedosos derivados de pirazolo-pirrolo-pirimidina como inhibidores de p2x3 | |
BR112017005218A2 (pt) | mistura de compostos, processo para fabricar uma mistura, formulação aquosa, e, uso de misturas de compostos. | |
UY35536A (es) | ?derivados de sulfonamida?. | |
BR112015031998A2 (pt) | formulação detergente, produto detergente, e processos para preparar uma formulação detergente | |
AR077371A1 (es) | DERIVADOS DE PIRAZOL, SU PREPARACIoN Y SU APLICACIoN EN LA TERAPIA DEL CÁNCER | |
BR112015002041A2 (pt) | formulação transdérmica contendo inibidores de cox | |
CL2017002449A1 (es) | Compuestos heterocíclicos y su uso en la prevención o tratamiento de las infecciones bacterianas | |
BR112015014737A2 (pt) | compostos spiroisoxazolina tendo uma atividade potencializando a atividade de um antibiótico | |
BR112018013429A2 (pt) | ?composto, composição, método para o controle de um nematoide, utilização de uma composição e semente? | |
GT200500214A (es) | Amidas del acido 5 y 6-aminoalquil indol-2-carboxilico 3-sustituidas y análogos relacionados como inhibidores de la caseína cinasa epsilon |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021 |
|
B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |