MX2019003052A - Composiciones para compuestos de agente terapeutico de molecula pequeña. - Google Patents
Composiciones para compuestos de agente terapeutico de molecula pequeña.Info
- Publication number
- MX2019003052A MX2019003052A MX2019003052A MX2019003052A MX2019003052A MX 2019003052 A MX2019003052 A MX 2019003052A MX 2019003052 A MX2019003052 A MX 2019003052A MX 2019003052 A MX2019003052 A MX 2019003052A MX 2019003052 A MX2019003052 A MX 2019003052A
- Authority
- MX
- Mexico
- Prior art keywords
- therapeutic agent
- small molecule
- molecule therapeutic
- organic acid
- compositions
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 5
- 150000003384 small molecules Chemical class 0.000 title abstract 5
- 229940124597 therapeutic agent Drugs 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title 1
- 150000007524 organic acids Chemical class 0.000 abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a una composición que comprende una suspensión acuosa que comprende un agente terapéutico de molécula pequeña y un ácido orgánico. El agente terapéutico de molécula pequeña es una base y que tiene una solubilidad en agua a temperatura ambiente de menos de aproximadamente 1.0 g/L. El ácido orgánico tiene una solubilidad en agua a temperatura ambiente de entre 0.1 y 10, tiene una masa molar de menos de 500 gramos por mol, y/o mantiene un pH de la suspensión en su ambiente de uso de entre 3.0-6.5. El ácido orgánico mejora la solubilidad del agente terapéutico de molécula pequeña y cuando se presenta en exceso estequiométrico, el ácido orgánico conduce la liberación del agente terapéutico de molécula pequeña en un ambiente amortiguado de uso por periodos prolongados de, por ejemplo, seis meses hasta un año. También se describen dispositivos que comprenden las composiciones y métodos de tratamiento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662399083P | 2016-09-23 | 2016-09-23 | |
PCT/US2017/053074 WO2018057968A1 (en) | 2016-09-23 | 2017-09-22 | Compositions for small molecule therapeutic agent compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019003052A true MX2019003052A (es) | 2019-11-25 |
Family
ID=60083440
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019003052A MX2019003052A (es) | 2016-09-23 | 2017-09-22 | Composiciones para compuestos de agente terapeutico de molecula pequeña. |
MX2023003010A MX2023003010A (es) | 2016-09-23 | 2019-03-15 | Composiciones para compuestos de agente terapeutico de molecula peque?a. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023003010A MX2023003010A (es) | 2016-09-23 | 2019-03-15 | Composiciones para compuestos de agente terapeutico de molecula peque?a. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20190224322A1 (es) |
EP (1) | EP3515407A1 (es) |
JP (2) | JP2019529564A (es) |
KR (2) | KR20230093349A (es) |
CN (1) | CN109890365A (es) |
AU (1) | AU2017331340B2 (es) |
BR (1) | BR112019005542A2 (es) |
CA (1) | CA3037531A1 (es) |
MX (2) | MX2019003052A (es) |
WO (1) | WO2018057968A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2019228497A1 (en) * | 2018-02-27 | 2020-09-17 | Delpor, Inc. | Compositions for small molecule therapeutic agent compounds |
CA3149545A1 (en) * | 2019-08-28 | 2021-03-04 | Delpor, Inc. | Compositions for small molecule therapeutic agent compounds |
WO2022176017A1 (ja) * | 2021-02-16 | 2022-08-25 | 大塚製薬株式会社 | 非晶質体及び当該非晶質体を含む組成物 |
TWI820673B (zh) * | 2021-04-13 | 2023-11-01 | 大陸商上海雲晟研新生物科技有限公司 | 布瑞哌唑口溶膜組合物、其製備方法及用途 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5453425A (en) * | 1994-07-11 | 1995-09-26 | Janssen Pharmaceutica N.V. | Risperidone oral formulation |
US7592300B2 (en) * | 2003-11-24 | 2009-09-22 | The Dial Corporation | Antimicrobial compositions containing an aromatic carboxylic acid and a hydric solvent |
AR048272A1 (es) * | 2004-03-18 | 2006-04-12 | Lek Pharmaceuticals | Sintesis de 2 metil - 4- (4- metil -1- piperazinil) - 10 h- tieno ( 2,3-b) (1,5) benzodiazepina y sus sales, metodos para su preparacion, composiciones farmaceuticas que la contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mentales. |
PL377084A1 (pl) * | 2005-09-15 | 2007-03-19 | Koźluk Tomasz Nobilus Ent | Nowe związki olanzapiny i sposób ich wytwarzania |
NZ584370A (en) * | 2007-10-09 | 2011-04-29 | Cipla Ltd | Processes for the preparation of paliperidone and pharmaceutically acceptable salts thereof and intermediates for use in the processes |
WO2009135091A1 (en) * | 2008-04-30 | 2009-11-05 | Medivation Technologies, Inc. | Use of asenapine and related compounds for the treatment of neuronal or non-neuronal diseases or conditions |
EP3006024B1 (en) * | 2009-01-20 | 2019-03-20 | Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center | Benzoic acid or salts thereof to enhance the activity of a neuropharmaceutical |
US9561352B2 (en) | 2009-03-12 | 2017-02-07 | Delpor, Inc. | Implantable device for long-term delivery of drugs |
JP5664871B2 (ja) * | 2009-06-19 | 2015-02-04 | 株式会社 メドレックス | アリピプラゾールと有機酸を有効成分とする外用剤組成物 |
HRP20211853T1 (hr) * | 2010-05-31 | 2022-03-04 | Laboratorios Farmaceuticos Rovi, S.A. | Sastavi in situ injekcijskih biorazgradivih implantata |
KR101408370B1 (ko) * | 2012-06-26 | 2014-06-18 | 주식회사지씨비 | 아리피프라졸-유기산 공결정을 함유하는 제제 및 이의 제조 방법 |
CA2885941A1 (en) * | 2012-09-28 | 2014-04-03 | Delpor, Inc. | Device and method for sustained release of antipsychotic medications |
CN106474058B (zh) * | 2015-08-31 | 2020-01-07 | 南京诺瑞特医药科技有限公司 | 具有延长的保质期的阿立哌唑可注射悬浮液制剂 |
-
2017
- 2017-09-22 BR BR112019005542A patent/BR112019005542A2/pt active Search and Examination
- 2017-09-22 AU AU2017331340A patent/AU2017331340B2/en active Active
- 2017-09-22 EP EP17784087.3A patent/EP3515407A1/en active Pending
- 2017-09-22 KR KR1020237019611A patent/KR20230093349A/ko not_active Application Discontinuation
- 2017-09-22 CA CA3037531A patent/CA3037531A1/en active Pending
- 2017-09-22 MX MX2019003052A patent/MX2019003052A/es unknown
- 2017-09-22 KR KR1020197011224A patent/KR20190066608A/ko not_active IP Right Cessation
- 2017-09-22 WO PCT/US2017/053074 patent/WO2018057968A1/en unknown
- 2017-09-22 CN CN201780065098.0A patent/CN109890365A/zh active Pending
- 2017-09-22 US US16/336,088 patent/US20190224322A1/en active Pending
- 2017-09-22 JP JP2019537753A patent/JP2019529564A/ja active Pending
-
2019
- 2019-03-15 MX MX2023003010A patent/MX2023003010A/es unknown
-
2022
- 2022-09-09 JP JP2022144103A patent/JP2022188046A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112019005542A2 (pt) | 2019-06-18 |
KR20230093349A (ko) | 2023-06-27 |
MX2023003010A (es) | 2023-04-10 |
CN109890365A (zh) | 2019-06-14 |
CA3037531A1 (en) | 2018-03-29 |
US20190224322A1 (en) | 2019-07-25 |
KR20190066608A (ko) | 2019-06-13 |
JP2022188046A (ja) | 2022-12-20 |
AU2017331340A1 (en) | 2019-04-11 |
AU2017331340B2 (en) | 2023-09-28 |
EP3515407A1 (en) | 2019-07-31 |
WO2018057968A1 (en) | 2018-03-29 |
JP2019529564A (ja) | 2019-10-17 |
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