JP7605735B2 - 同種異系細胞組成物およびその使用方法 - Google Patents

同種異系細胞組成物およびその使用方法 Download PDF

Info

Publication number
JP7605735B2
JP7605735B2 JP2021512393A JP2021512393A JP7605735B2 JP 7605735 B2 JP7605735 B2 JP 7605735B2 JP 2021512393 A JP2021512393 A JP 2021512393A JP 2021512393 A JP2021512393 A JP 2021512393A JP 7605735 B2 JP7605735 B2 JP 7605735B2
Authority
JP
Japan
Prior art keywords
cells
modified
cell
csr
present disclosure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021512393A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021536249A5 (https=
JPWO2020051374A5 (https=
JP2021536249A (ja
Inventor
エム.オスタータグ エリック
シェドロック デボン
Original Assignee
ポセイダ セラピューティクス,インコーポレイティド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ポセイダ セラピューティクス,インコーポレイティド filed Critical ポセイダ セラピューティクス,インコーポレイティド
Publication of JP2021536249A publication Critical patent/JP2021536249A/ja
Publication of JP2021536249A5 publication Critical patent/JP2021536249A5/ja
Publication of JPWO2020051374A5 publication Critical patent/JPWO2020051374A5/ja
Priority to JP2024217381A priority Critical patent/JP2025028160A/ja
Application granted granted Critical
Publication of JP7605735B2 publication Critical patent/JP7605735B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31Chimeric antigen receptors [CAR]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32T-cell receptors [TCR]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70507CD2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70539MHC-molecules, e.g. HLA-molecules
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/33Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50Cell markers; Cell surface determinants
    • C12N2501/599Cell markers; Cell surface determinants with CD designations not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/90Vectors containing a transposable element

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
JP2021512393A 2018-09-05 2019-09-05 同種異系細胞組成物およびその使用方法 Active JP7605735B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024217381A JP2025028160A (ja) 2018-09-05 2024-12-12 同種異系細胞組成物およびその使用方法

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201862727498P 2018-09-05 2018-09-05
US62/727,498 2018-09-05
US201862744073P 2018-10-10 2018-10-10
US62/744,073 2018-10-10
US201962815334P 2019-03-07 2019-03-07
US62/815,334 2019-03-07
US201962815880P 2019-03-08 2019-03-08
US62/815,880 2019-03-08
PCT/US2019/049816 WO2020051374A1 (en) 2018-09-05 2019-09-05 Allogeneic cell compositions and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024217381A Division JP2025028160A (ja) 2018-09-05 2024-12-12 同種異系細胞組成物およびその使用方法

Publications (4)

Publication Number Publication Date
JP2021536249A JP2021536249A (ja) 2021-12-27
JP2021536249A5 JP2021536249A5 (https=) 2022-09-12
JPWO2020051374A5 JPWO2020051374A5 (https=) 2022-09-12
JP7605735B2 true JP7605735B2 (ja) 2024-12-24

Family

ID=68136519

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021512393A Active JP7605735B2 (ja) 2018-09-05 2019-09-05 同種異系細胞組成物およびその使用方法
JP2024217381A Pending JP2025028160A (ja) 2018-09-05 2024-12-12 同種異系細胞組成物およびその使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024217381A Pending JP2025028160A (ja) 2018-09-05 2024-12-12 同種異系細胞組成物およびその使用方法

Country Status (8)

Country Link
US (1) US20220389077A1 (https=)
EP (1) EP3847197A1 (https=)
JP (2) JP7605735B2 (https=)
KR (1) KR20210073520A (https=)
CN (2) CN119119296A (https=)
AU (1) AU2019335014A1 (https=)
CA (1) CA3111384A1 (https=)
WO (1) WO2020051374A1 (https=)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018329741B2 (en) * 2017-09-08 2025-02-20 Poseida Therapeutics, Inc. Compositions and methods for chimeric ligand receptor (CLR)-mediated conditional gene expression
KR20200138325A (ko) 2018-03-28 2020-12-09 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 이펙터 t 세포를 재프로그래밍하기 위한 히스톤 개질제의 용도
SG10201802979VA (en) * 2018-04-10 2019-11-28 Kah Meng Lim Immunological extract and method of production
WO2020117715A1 (en) 2018-12-03 2020-06-11 Board Of Regents, The University Of Texas System Oligo-benzamide analogs and their use in cancer treatment
KR20220004028A (ko) * 2019-04-26 2022-01-11 알로젠 테라퓨틱스 인코포레이티드 동종 car t 세포를 제조하는 방법
CN114761424B (zh) * 2019-09-05 2025-09-19 波赛达治疗公司 同种异体细胞组合物和使用方法
CA3166420A1 (en) * 2020-01-14 2021-07-22 Synthekine, Inc. Il2 orthologs and methods of use
US20230079539A1 (en) * 2020-02-10 2023-03-16 Board Of Regents, The University Of Texas System Methods for rapid cloning and expression of hla class i cells
US12540335B2 (en) 2020-03-04 2026-02-03 Poseida Therapeutics, Inc. Compositions and methods for the treatment of metabolic liver disorders
WO2021183795A1 (en) * 2020-03-11 2021-09-16 Poseida Therapeutics, Inc. Chimeric stimulatory receptors and methods of use in t cell activation and differentiation
KR20210121585A (ko) * 2020-03-30 2021-10-08 한국세라믹기술원 반응성 및 안정성 그리고 항체회수가 향상된 z-도메인 및 칼시퀘스트린 융합단백질 및 이를 이용한 항체의 분리 및 정제 방법
CN116761815A (zh) * 2020-07-29 2023-09-15 优瑞科生物技术公司 T细胞和嵌合刺激受体及其应用
CN112375138B (zh) * 2020-11-13 2022-12-13 中元汇吉生物技术股份有限公司 一种重组载脂蛋白e和应用
CN112402592B (zh) * 2020-12-04 2023-06-02 中国人民解放军陆军军医大学 Spink7蛋白在制备促进过度炎症创面愈合的药物中的应用
CN112480242B (zh) * 2020-12-04 2023-06-06 中国人民解放军陆军军医大学 Spink7蛋白在制备预防和/或治疗溃疡性结肠炎的药物中的应用
IL303712A (en) * 2020-12-18 2023-08-01 Cullinan Amber Corp Bi-functional linear fusion collagen-localized immunomodulatory molecules and methods thereofלטו
CN112941039A (zh) * 2021-02-01 2021-06-11 南京大学 一种新型类囊泡溶瘤病毒及其在制备抗肿瘤药物上的应用
WO2022192895A1 (en) * 2021-03-10 2022-09-15 H. Lee Moffitt Cancer Center And Research Institute Inc. Compositions and methods to reduce therapeutic t cell toxicity
CN113249361A (zh) * 2021-03-29 2021-08-13 南京欧凯生物科技有限公司 基质金属蛋白酶及其制备方法
KR20230171994A (ko) 2021-04-16 2023-12-21 셀진 코포레이션 선행 줄기 세포 이식을 받은 환자에서의 t 세포 요법
TWI828126B (zh) * 2021-04-27 2024-01-01 中央研究院 用以治療高三酸甘油脂血症或其相關疾病的方法
CN113481185B (zh) * 2021-08-05 2022-12-02 云南师范大学 一种耐盐β-半乳糖苷酶GalNC2-13及其制备方法和应用
CN113846070B (zh) * 2021-10-18 2023-05-16 翌圣生物科技(上海)股份有限公司 高活性的mTET2酶突变体、其编码DNA及其应用
WO2023081735A1 (en) 2021-11-03 2023-05-11 Celgene Corporation Chimeric antigen receptors specific for b-cell maturation antigen for use in treating myeloma
CN113957075B (zh) * 2021-11-22 2023-04-07 百世诺(北京)医学检验实验室有限公司 突变的遗传性心律失常基因及其应用
CN116178562A (zh) * 2021-11-29 2023-05-30 四川大学华西医院 基于efna1构建的嵌合抗原受体免疫细胞制备及其应用
CN115873902A (zh) * 2021-11-30 2023-03-31 百奥赛图(北京)医药科技股份有限公司 一种cd200和/或cd200r基因人源化的非人动物及其构建方法和应用
CN114539376B (zh) * 2022-01-17 2023-06-13 中国水产科学研究院南海水产研究所 拟穴青蟹生物标记物cyp2基因及其在制备病理检测试剂中的应用
CN114487448B (zh) * 2022-01-21 2022-10-18 天津天海新域生物科技有限公司 用于检测重症肌无力相关抗体的组合物、试剂盒及应用
JP2025504002A (ja) 2022-01-28 2025-02-06 ジュノー セラピューティクス インコーポレイテッド 細胞組成物を製造する方法
CN114113639B (zh) * 2022-01-29 2022-04-19 北京大有天弘科技有限公司 一种血型抗体检测方法及其应用
CN114137231B (zh) * 2022-01-29 2022-04-29 北京大有天弘科技有限公司 一种血型不规则抗体的检测试剂盒及其应用
WO2023151620A1 (zh) * 2022-02-09 2023-08-17 恺兴生命科技(上海)有限公司 用于细胞免疫学的组合物和方法
CN114646764B (zh) * 2022-04-08 2024-11-29 华南农业大学 一种arhgap35蛋白在猪x和y精子鉴定或分离中的应用
WO2023220655A1 (en) 2022-05-11 2023-11-16 Celgene Corporation Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy
US20250295771A1 (en) 2022-05-11 2025-09-25 Celgene Corporation Methods and uses related to t cell therapy and production of same
CN114958862B (zh) * 2022-05-23 2023-12-08 郑州伊美诺生物技术有限公司 检测慢性间质性肾炎的重组抗原的制备方法
WO2023230548A1 (en) 2022-05-25 2023-11-30 Celgene Corporation Method for predicting response to a t cell therapy
EP4532695A1 (en) 2022-05-25 2025-04-09 Celgene Corporation Methods of manufacturing t cell therapies
CN114920816B (zh) * 2022-06-06 2024-04-05 孙英贤 Baf155突变基因及其制药用途
CN114989287B (zh) * 2022-06-06 2024-04-09 孙英贤 脱乙酰化修饰的baf155蛋白及其制药用途
WO2024023245A1 (en) * 2022-07-27 2024-02-01 Biocell Innovations Pte. Ltd. Production of cells and viral vectors
CN115747170B (zh) * 2022-08-29 2023-08-04 四川大学 一种豇豆褪绿斑驳病毒-多肽复合物及其在骨质疏松治疗中的应用
CN115820580A (zh) * 2022-08-31 2023-03-21 武汉爱博泰克生物科技有限公司 活性重组hTET2蛋白的表达及纯化方法
CN115558712B (zh) * 2022-09-22 2026-03-24 华中科技大学同济医学院附属协和医院 Fam177a1的新用途
CN115850512B (zh) * 2022-10-14 2025-11-07 江苏大学 一种用于靶向治疗肿瘤的重组融合蛋白及其制备方法
WO2024097905A1 (en) 2022-11-02 2024-05-10 Celgene Corporation Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy
CN115976004B (zh) * 2022-12-27 2024-07-09 天津科技大学 一种黄体酮17α-羟化酶突变体及其应用
JP2026503550A (ja) 2023-01-20 2026-01-29 ポセイダ セラピューティクス,インコーポレイティド リピドイド化合物ならびに関連する組成物および使用
GB2626983A (en) * 2023-02-10 2024-08-14 Quell Therapeutics Ltd Protein
WO2024168192A1 (en) 2023-02-10 2024-08-15 Celgene Corporation Assessment of bcma in biological samples
CN116253778B (zh) * 2023-03-03 2025-09-23 中山大学 一种缓解长春新碱致神经病理性疼痛的多肽及其应用
CN118109416B (zh) * 2023-03-30 2024-11-22 广州百吉生物制药有限公司 功能增强型工程化免疫细胞及其制备和应用
KR20250173518A (ko) 2023-04-05 2025-12-10 포세이다 테라퓨틱스, 인크. 트랜스포사제 폴리뉴클레오티드 및 그의 용도
CN121219409A (zh) 2023-04-05 2025-12-26 波西达治疗公司 转座酶及其用途
KR20250167671A (ko) 2023-04-05 2025-12-01 포세이다 테라퓨틱스, 인크. 키메라 트랜스포사제 및 그의 용도
CN116478271B (zh) * 2023-06-19 2023-08-29 青岛大学 半滑舌鳎抗病基因PPARα及其编码蛋白的应用
CN119320771A (zh) * 2023-07-17 2025-01-17 北京艺妙神州医药科技有限公司 用于敲除t细胞中的trac和b2m的试剂和方法
CN116948015B (zh) * 2023-07-18 2024-07-05 山西锦波生物医药股份有限公司 生物合成人体结构性材料xxii型胶原蛋白的方法
WO2025029930A1 (en) * 2023-07-31 2025-02-06 Legend Biotech Ireland Limited Cells overexpressing cd31 and methods of use thereof
CN116854801A (zh) * 2023-08-21 2023-10-10 广东省人民医院 Hand1重组蛋白及其制备方法和在治疗扩张性心肌病药物中的应用
WO2025049925A2 (en) 2023-09-01 2025-03-06 Poseida Therapeutics, Inc. Lipidoid compounds and related compositions and uses
WO2025055927A1 (en) * 2023-09-13 2025-03-20 Qihan Hong Kong Limited Immunotherapies using hypoimmunogenic engineered cells
WO2025064507A1 (en) 2023-09-19 2025-03-27 Poseida Therapeutics, Inc. Compositions and methods for integration of viral vectors
CN117586418B (zh) * 2023-11-08 2025-07-15 东南大学 一种丝氨酸蛋白酶抑制剂及其应用
WO2025106376A1 (en) * 2023-11-17 2025-05-22 Dna Twopointo Inc. Mammalian cell lines for transient protein production
CN117551621B (zh) * 2023-11-20 2024-04-30 梅州市人民医院(梅州市医学科学院) 一种杂交瘤细胞株l008、单克隆抗体及其应用
CN117883382B (zh) * 2023-11-27 2025-02-14 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) 高效递送疫苗的脂质体载体及脂质体疫苗的制备与用途
CN117820434B (zh) * 2023-12-31 2024-11-19 武汉优恩生物科技有限公司 牛羊妊娠相关糖蛋白的多肽抗原及应用
WO2025156492A1 (zh) * 2024-01-23 2025-07-31 星尘股份有限公司 转座酶及其用途
WO2025160432A1 (en) 2024-01-26 2025-07-31 Poseida Therapeutics, Inc. Methods and compositions for enhancing in vivo persistence and potency of cell therapy
CN118146342A (zh) * 2024-02-06 2024-06-07 同济大学 一种Smad5突变体及在防治糖尿病中的应用
CN117919389B (zh) * 2024-03-22 2024-07-23 上海南方模式生物科技股份有限公司 肿瘤新抗原dna疫苗
CN118584109B (zh) * 2024-03-26 2025-08-15 首都医科大学附属北京胸科医院 一种筛选耐药性肺癌的生物标志物
WO2025221789A1 (en) 2024-04-16 2025-10-23 Poseida Therapeutics, Inc. Compositions and methods for use in car/tcr cell therapies
CN118308420B (zh) * 2024-04-19 2025-06-03 东北农业大学 一种大豆基因Glyma.18G041900的应用
CN118360271B (zh) * 2024-05-07 2025-12-05 中国海洋大学 一种脂肪酶突变体及其在提升白酒酯类风味物质中的应用
CN118240829B (zh) * 2024-05-21 2024-07-23 华南农业大学 NompC基因在防治桔小实蝇中的应用
WO2026080393A1 (en) 2024-10-07 2026-04-16 Poseida Therapeutics, Inc. Compositions and methods for use in car cell therapies
CN119736407A (zh) * 2024-12-27 2025-04-01 西北农林科技大学 一种提高动物生长速度和大小的stc2基因编码序列突变体的应用
CN119899820B (zh) * 2025-01-23 2026-04-03 深圳开悦生命科技有限公司 Dhx8融合蛋白及其制备方法
CN120209114B (zh) * 2025-03-07 2026-04-07 首都医科大学 一种含有penk蛋白的组合物及其应用
CN119874865B (zh) * 2025-03-11 2025-11-25 东北林业大学 一种溪荪ost48蛋白在植物促分蘖中的应用
CN120192430B (zh) * 2025-03-24 2025-08-22 安康市中心医院 一种基于硒修饰的心肌保护多肽及其制备方法与应用
CN119978086B (zh) * 2025-03-31 2025-10-17 中国农业大学 一种调控植物生长发育的蛋白质dap1及其编码基因和应用
CN120607598B (zh) * 2025-05-16 2026-02-27 安徽大学 人源先锋转录因子sox15 hmg结构域重组蛋白及其制备方法
CN120624647B (zh) * 2025-05-30 2026-04-03 山西省肿瘤医院 鼻咽癌诊断或预测的甲基化标志物组合及应用、试剂盒和计算机可读存储介质
CN120591344B (zh) * 2025-06-13 2026-04-03 广州景旸生物科技有限公司 Col3a1蛋白的制备方法及其应用
CN121203036A (zh) * 2025-09-24 2025-12-26 北京多美康医药科技有限公司 一种重组型胶原蛋白iii+x及其制备方法和应用
CN121186348B (zh) * 2025-11-25 2026-02-24 北京大学人民医院 瓜氨酸化内凝集素-1多肽在制备类风湿关节炎诊断产品中的应用
CN121471381A (zh) * 2026-01-12 2026-02-06 南京医科大学 Tat-po1及其在治疗神经退行性疾病肌萎缩侧索硬化症中的应用
CN121538143B (zh) * 2026-01-20 2026-04-10 北京绿色康成生物技术有限公司 生产麦角硫因的重组微生物、重组表达载体及制备麦角硫因的方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4656134A (en) 1982-01-11 1987-04-07 Board Of Trustees Of Leland Stanford Jr. University Gene amplification in eukaryotic cells
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4766067A (en) 1985-05-31 1988-08-23 President And Fellows Of Harvard College Gene amplification
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US4889818A (en) 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US4921794A (en) 1987-01-14 1990-05-01 President And Fellows Of Harvard College T7 DNA polymerase
US4795699A (en) 1987-01-14 1989-01-03 President And Fellows Of Harvard College T7 DNA polymerase
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US5142033A (en) 1988-09-23 1992-08-25 Hoffmann-La Roche Inc. Structure-independent DNA amplification by the polymerase chain reaction
US5091310A (en) 1988-09-23 1992-02-25 Cetus Corporation Structure-independent dna amplification by the polymerase chain reaction
US5066584A (en) 1988-09-23 1991-11-19 Cetus Corporation Methods for generating single stranded dna by the polymerase chain reaction
US4994370A (en) 1989-01-03 1991-02-19 The United States Of America As Represented By The Department Of Health And Human Services DNA amplification technique
US5266491A (en) 1989-03-14 1993-11-30 Mochida Pharmaceutical Co., Ltd. DNA fragment and expression plasmid containing the DNA fragment
US5580734A (en) 1990-07-13 1996-12-03 Transkaryotic Therapies, Inc. Method of producing a physical map contigous DNA sequences
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
US5733761A (en) 1991-11-05 1998-03-31 Transkaryotic Therapies, Inc. Protein production and protein delivery
US5712149A (en) * 1995-02-03 1998-01-27 Cell Genesys, Inc. Chimeric receptor molecules for delivery of co-stimulatory signals
EP3783098A1 (en) * 2013-05-14 2021-02-24 Board Of Regents, The University Of Texas System Human application of engineered chimeric antigen receptor (car) t-cells
TWI750110B (zh) * 2014-07-21 2021-12-21 瑞士商諾華公司 使用人類化抗-bcma嵌合抗原受體治療癌症
GB201415347D0 (en) * 2014-08-29 2014-10-15 Ucl Business Plc Signalling system
US10888608B2 (en) * 2014-09-02 2021-01-12 Bellicum Pharmaceuticals, Inc. Costimulation of chimeric antigen receptors by MyD88 and CD40 polypeptides
EP4706777A2 (en) * 2016-04-15 2026-03-11 Alpine Immune Sciences, Inc. Cd80 variant immunomodulatory proteins and uses thereof
JP7114490B2 (ja) * 2016-06-24 2022-08-08 アイセル・ジーン・セラピューティクス・エルエルシー キメラ抗体受容体(CARs)の構成およびその使用方法
AU2018236461B2 (en) * 2017-03-17 2025-03-27 Fred Hutchinson Cancer Center Immunomodulatory fusion proteins and uses thereof
CA3071683A1 (en) * 2017-08-08 2019-02-14 Sangamo Therapeutics, Inc. Chimeric antigen receptor mediated cell targeting
KR102849343B1 (ko) * 2018-03-07 2025-08-25 포세이다 테라퓨틱스, 인크. Cartyrin 조성물 및 사용 방법

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Journal for ImmunoTherapy of Cancer,2013年,Vol. 1, Suppl 1,P14,doi:10.1186/2051-1426-1-S1-P14
臨床化学,1996年,Vol. 25,p. 60-66

Also Published As

Publication number Publication date
KR20210073520A (ko) 2021-06-21
AU2019335014A1 (en) 2021-03-25
EP3847197A1 (en) 2021-07-14
CN113383018A (zh) 2021-09-10
CN113383018B (zh) 2024-09-10
CN119119296A (zh) 2024-12-13
CA3111384A1 (en) 2020-03-12
JP2021536249A (ja) 2021-12-27
JP2025028160A (ja) 2025-02-28
WO2020051374A9 (en) 2021-07-15
US20220389077A1 (en) 2022-12-08
WO2020051374A1 (en) 2020-03-12

Similar Documents

Publication Publication Date Title
JP7605735B2 (ja) 同種異系細胞組成物およびその使用方法
JP7576639B2 (ja) 造血幹細胞の選択的除去と置換のための組成物と方法
JP7749624B2 (ja) Vcar組成物とその利用法
KR102849343B1 (ko) Cartyrin 조성물 및 사용 방법
JP2024109657A (ja) キメラリガンド受容体(clr)介在性の条件遺伝子発現のための組成物および方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220902

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220902

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230808

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20231107

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240208

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240521

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240820

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20241112

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20241212

R150 Certificate of patent or registration of utility model

Ref document number: 7605735

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150