JP7593939B2 - 抗ｍｅｒｔｋ抗体及びその使用方法 - Google Patents

抗ｍｅｒｔｋ抗体及びその使用方法 Download PDF

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Publication number
JP7593939B2
JP7593939B2 JP2021560968A JP2021560968A JP7593939B2 JP 7593939 B2 JP7593939 B2 JP 7593939B2 JP 2021560968 A JP2021560968 A JP 2021560968A JP 2021560968 A JP2021560968 A JP 2021560968A JP 7593939 B2 JP7593939 B2 JP 7593939B2
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seq
amino acid
mertk
acid sequence
antibody
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JP2022529154A (ja
JP2022529154A5 (enExample
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ウェイ－チン リャン，
ウェイユー リン，
ヤン ウー，
ミンホン ヤン，
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Genentech Inc
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2021560968A 2019-04-19 2020-04-17 抗ｍｅｒｔｋ抗体及びその使用方法 Active JP7593939B2 (ja)

Priority Applications (1)

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JP2024203545A JP2025037921A (ja) 2019-04-19 2024-11-21 抗ｍｅｒｔｋ抗体及びその使用方法

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US201962836580P 2019-04-19 2019-04-19
US62/836,580 2019-04-19
US201962890858P 2019-08-23 2019-08-23
US62/890,858 2019-08-23
PCT/US2020/028828 WO2020214995A1 (en) 2019-04-19 2020-04-17 Anti-mertk antibodies and their methods of use

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JP2022529154A JP2022529154A (ja) 2022-06-17
JP2022529154A5 JP2022529154A5 (enExample) 2023-04-24
JP7593939B2 true JP7593939B2 (ja) 2024-12-03

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JP2024203545A Pending JP2025037921A (ja) 2019-04-19 2024-11-21 抗ｍｅｒｔｋ抗体及びその使用方法

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US (2) US20220135701A1 (enExample)
EP (1) EP3956364A1 (enExample)
JP (2) JP7593939B2 (enExample)
KR (1) KR20220002967A (enExample)
CN (1) CN114364703A (enExample)
AU (1) AU2020258480B2 (enExample)
BR (1) BR112021020867A2 (enExample)
CA (1) CA3134522A1 (enExample)
IL (1) IL287282A (enExample)
MX (1) MX2021012692A (enExample)
TW (1) TW202043291A (enExample)
WO (1) WO2020214995A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2022007231A (es) 2019-12-13 2022-07-12 Alector Llc Anticuerpos anti-mertk y metodos de uso de los mismos.
CN116075525A (zh) * 2020-03-31 2023-05-05 艾莱克特有限责任公司 抗mertk抗体及其使用方法
AR123855A1 (es) * 2020-10-20 2023-01-18 Genentech Inc Anticuerpos anti-mertk conjugados con peg y métodos de uso
EP4355786A1 (en) 2021-06-16 2024-04-24 Alector LLC Bispecific anti-mertk and anti-pdl1 antibodies and methods of use thereof
WO2022266221A1 (en) 2021-06-16 2022-12-22 Alector Llc Monovalent anti-mertk antibodies and methods of use thereof
IL311952A (en) * 2021-10-15 2024-06-01 Chiome Bioscience Inc Antibody or fragment thereof binding specifically to mertk, and anti-tumor agent
WO2024020063A2 (en) * 2022-07-19 2024-01-25 La Jolla Institute For Immunology Anti-hrf antibodies
CN119654342B (zh) * 2022-07-28 2025-07-18 乐普创一生物科技（上海）有限公司 抗MerTK抗体及其用途
CN121673366A (zh) * 2026-02-10 2026-03-17 吉林农业大学 小分子肽及应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018504105A (ja) 2014-12-22 2018-02-15 ザ ロックフェラー ユニバーシティー 抗ｍｅｒｔｋアゴニスト抗体及びその使用
WO2019005756A1 (en) 2017-06-28 2019-01-03 The Rockefeller University CONJUGATES AGONIST ANTIBODY ANTI-MERTK-MEDICINE
JP2022512642A (ja) 2018-10-09 2022-02-07 ブリストル－マイヤーズ スクイブ カンパニー がんを治療するための抗ＭｅｒＴＫ抗体

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