AU2020258480B2 - Anti-mertk antibodies and their methods of use - Google Patents

Anti-mertk antibodies and their methods of use

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Publication number
AU2020258480B2
AU2020258480B2 AU2020258480A AU2020258480A AU2020258480B2 AU 2020258480 B2 AU2020258480 B2 AU 2020258480B2 AU 2020258480 A AU2020258480 A AU 2020258480A AU 2020258480 A AU2020258480 A AU 2020258480A AU 2020258480 B2 AU2020258480 B2 AU 2020258480B2
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AU
Australia
Prior art keywords
seq
amino acid
acid sequence
mertk
antibody
Prior art date
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Active
Application number
AU2020258480A
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English (en)
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AU2020258480A1 (en
Inventor
Wei-Ching Liang
Weiyu Lin
Yan Wu
Minhong Yan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
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Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of AU2020258480A1 publication Critical patent/AU2020258480A1/en
Application granted granted Critical
Publication of AU2020258480B2 publication Critical patent/AU2020258480B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2020258480A 2019-04-19 2020-04-17 Anti-mertk antibodies and their methods of use Active AU2020258480B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962836580P 2019-04-19 2019-04-19
US62/836,580 2019-04-19
US201962890858P 2019-08-23 2019-08-23
US62/890,858 2019-08-23
PCT/US2020/028828 WO2020214995A1 (en) 2019-04-19 2020-04-17 Anti-mertk antibodies and their methods of use

Publications (2)

Publication Number Publication Date
AU2020258480A1 AU2020258480A1 (en) 2021-10-21
AU2020258480B2 true AU2020258480B2 (en) 2026-04-02

Family

ID=70680594

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020258480A Active AU2020258480B2 (en) 2019-04-19 2020-04-17 Anti-mertk antibodies and their methods of use

Country Status (12)

Country Link
US (2) US20220135701A1 (enExample)
EP (1) EP3956364A1 (enExample)
JP (2) JP7593939B2 (enExample)
KR (1) KR20220002967A (enExample)
CN (1) CN114364703A (enExample)
AU (1) AU2020258480B2 (enExample)
BR (1) BR112021020867A2 (enExample)
CA (1) CA3134522A1 (enExample)
IL (1) IL287282A (enExample)
MX (1) MX2021012692A (enExample)
TW (1) TW202043291A (enExample)
WO (1) WO2020214995A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20221326A1 (es) 2019-12-13 2022-09-09 Alector Llc Anticuerpos anti-mertk y metodos de uso de los mismos
WO2021202590A1 (en) * 2020-03-31 2021-10-07 Alector Llc Anti-mertk antibodies and methods of use thereof
WO2022086957A1 (en) * 2020-10-20 2022-04-28 Genentech, Inc. Peg-conjugated anti-mertk antibodies and methods of use
WO2022266221A1 (en) 2021-06-16 2022-12-22 Alector Llc Monovalent anti-mertk antibodies and methods of use thereof
CN117642426A (zh) 2021-06-16 2024-03-01 艾莱克特有限责任公司 双特异性抗MerTK和抗PDL1抗体及其使用方法
KR20240082341A (ko) * 2021-10-15 2024-06-10 치오메 바이오사이언스 가부시키가이샤 MerTK에 특이적으로 결합하는 항체 또는 이의 단편, 및 항종양제
WO2024020063A2 (en) * 2022-07-19 2024-01-25 La Jolla Institute For Immunology Anti-hrf antibodies
CN120484126B (zh) * 2022-07-28 2025-11-18 乐普创一生物科技（上海）有限公司 抗MerTK抗体及其用途
CN121673366B (zh) * 2026-02-10 2026-05-12 吉林农业大学 小分子肽及应用

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