JP7573528B2 - Ａｐｏｌ１の阻害剤及びその使用方法 - Google Patents

Ａｐｏｌ１の阻害剤及びその使用方法 Download PDF

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Publication number
JP7573528B2
JP7573528B2 JP2021534284A JP2021534284A JP7573528B2 JP 7573528 B2 JP7573528 B2 JP 7573528B2 JP 2021534284 A JP2021534284 A JP 2021534284A JP 2021534284 A JP2021534284 A JP 2021534284A JP 7573528 B2 JP7573528 B2 JP 7573528B2
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JP2022515369A5 (https=
JP2022515369A (ja
JPWO2020131807A5 (https=
Inventor
マイケル ブロドニー，
ケビン ガニオン，
カン－ニアン フー，
アレス メデク，
ピーター ローズ，
イー シー，
ムナ シュレスタ，
フェイス ウィトコス，
ジンロン ツァオ，
ジョン エイチ． カム，
レスリー エー． デーキン，
フランソワ デニス，
ウォーレン エー． ドルシュ，
アン フォティア，
マーティン ハメル，
エレイン ビー． クルーガー，
ブライアン レッドフォード，
スガンティニ エス． ナンタクマール，
オリバー ニコラス，
カミール セイエグ，
ティモシー ジェイ． センター，
ティアンシェン ワン，
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Publication of JPWO2020131807A5 publication Critical patent/JPWO2020131807A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP2021534284A 2018-12-17 2019-12-17 Ａｐｏｌ１の阻害剤及びその使用方法 Active JP7573528B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862780667P 2018-12-17 2018-12-17
US62/780,667 2018-12-17
PCT/US2019/066746 WO2020131807A1 (en) 2018-12-17 2019-12-17 Inhibitors of apol1 and methods of using same

Publications (4)

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JP2022515369A JP2022515369A (ja) 2022-02-18
JP2022515369A5 JP2022515369A5 (https=) 2022-12-23
JPWO2020131807A5 JPWO2020131807A5 (https=) 2022-12-23
JP7573528B2 true JP7573528B2 (ja) 2024-10-25

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EP (1) EP3897833B1 (https=)
JP (1) JP7573528B2 (https=)
KR (2) KR102912203B1 (https=)
CN (1) CN113453760B (https=)
AR (1) AR116913A1 (https=)
AU (1) AU2019405477B2 (https=)
CA (1) CA3121910A1 (https=)
CL (1) CL2021001561A1 (https=)
CO (1) CO2021009053A2 (https=)
CR (1) CR20210383A (https=)
DK (1) DK3897833T3 (https=)
DO (1) DOP2021000116A (https=)
EC (1) ECSP21052184A (https=)
FI (1) FI3897833T3 (https=)
IL (2) IL283592B2 (https=)
JO (3) JOP20210131A1 (https=)
MA (1) MA54538A (https=)
MX (1) MX2021007152A (https=)
PE (1) PE20212302A1 (https=)
SA (1) SA521422270B1 (https=)
SG (1) SG11202105769XA (https=)
TW (1) TWI848031B (https=)
UA (1) UA128375C2 (https=)
UY (1) UY38514A (https=)
WO (1) WO2020131807A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023529216A (ja) * 2020-06-12 2023-07-07 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｐｏｌ１の阻害剤及びその使用
JP2023530271A (ja) * 2020-06-12 2023-07-14 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｐｏｌ１の阻害剤及びこれを使用する方法

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TWI848031B (zh) 2018-12-17 2024-07-11 美商維泰克斯製藥公司 Apol1抑制劑及其使用方法
WO2021154997A1 (en) * 2020-01-29 2021-08-05 Vertex Pharmaceuticals Incorporated Inhibitors of apol1 and methods of using same
US20210246121A1 (en) * 2020-02-04 2021-08-12 Vertex Pharmaceuticals Incorporated Solid forms of apol1 inhibitor and methods of using same
CA3173808A1 (en) 2020-03-06 2021-09-10 Vertex Pharmaceuticals Incorporated Methods of treating apol-1 dependent focal segmental glomerulosclerosis
WO2021252863A1 (en) * 2020-06-12 2021-12-16 Vertex Pharmaceuticals Incorporated Solid forms of apol1 inhibitor and using the same
IL300298B2 (en) * 2020-08-26 2025-06-01 Vertex Pharma Inhibitors of apol1 and methods of using same
CN116997546A (zh) * 2021-02-19 2023-11-03 梅兹治疗公司 Apol1抑制剂及使用方法
MX2024002229A (es) * 2021-08-26 2024-05-15 Vertex Pharma Formas solidas de inhibidores de apolipoproteina l1 (apol1) espirotriciclicos y metodos de uso de las mismas.
CA3240523A1 (en) * 2021-11-30 2023-06-08 Vertex Pharmaceuticals Incorporated Spirocyclic inhibitors of apol1 and methods of using same
IL314330A (en) 2022-01-18 2024-09-01 Maze Therapeutics Inc Apol1 inhibitors and methods of use
CN119343353A (zh) * 2022-02-08 2025-01-21 弗特克斯药品有限公司 作为APOL1抑制剂的2-甲基-4',5'-二氢螺[哌啶-4,7'-噻吩并[2,3-c]吡喃]衍生物和其使用方法
WO2023194895A1 (en) 2022-04-06 2023-10-12 Glaxosmithkline Intellectual Property Development Limited Pyrrol derivatives as inhibitors of apolipoprotein l-1
US20260055083A1 (en) * 2022-08-19 2026-02-26 Maze Therapeutics, Inc. Apol1 inhibitors and methods of use
WO2025006262A1 (en) * 2023-06-29 2025-01-02 Omniab, Inc. Tetracyclic compounds containing a fused indole for treating apol1-mediated chronic kidney disease
GB202401326D0 (en) * 2024-02-01 2024-03-20 Podium Bio Ltd Novel compounds
KR20250122547A (ko) 2024-02-05 2025-08-14 서주사이언티픽 주식회사 AIoT 기반 방사성 동위원소 관리 시스템
WO2026012338A1 (zh) * 2024-07-09 2026-01-15 上海旭成医药科技有限公司 一种APOLs抑制剂

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
JP2023529216A (ja) * 2020-06-12 2023-07-07 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｐｏｌ１の阻害剤及びその使用
JP2023530271A (ja) * 2020-06-12 2023-07-14 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｐｏｌ１の阻害剤及びこれを使用する方法

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IL283592A (en) 2021-07-29
US20230271945A1 (en) 2023-08-31
US12060346B2 (en) 2024-08-13
JOP20210129A1 (ar) 2023-01-30
US20250042878A1 (en) 2025-02-06
ECSP21052184A (es) 2021-08-31
AU2019405477A1 (en) 2021-06-24
KR20260020195A (ko) 2026-02-10
AR116913A1 (es) 2021-06-23
US11618746B2 (en) 2023-04-04
SG11202105769XA (en) 2021-07-29
AU2019405477B2 (en) 2025-04-03
UA128375C2 (uk) 2024-06-26
JP2022515369A (ja) 2022-02-18
MA54538A (fr) 2021-10-27
JOP20210130A1 (ar) 2023-01-30
CO2021009053A2 (es) 2021-08-09
CR20210383A (es) 2021-09-22
CN113453760A (zh) 2021-09-28
SA521422270B1 (ar) 2024-02-18
DK3897833T3 (da) 2026-03-30
BR112021011564A2 (pt) 2021-08-31
EP3897833B1 (en) 2026-02-04
TW202039471A (zh) 2020-11-01
CL2021001561A1 (es) 2021-11-26
IL283592B1 (en) 2025-04-01
CA3121910A1 (en) 2020-06-25
IL319575A (en) 2025-05-01
KR20210116483A (ko) 2021-09-27
IL283592B2 (en) 2025-08-01
US20200377479A1 (en) 2020-12-03
EP3897833A1 (en) 2021-10-27
WO2020131807A1 (en) 2020-06-25
JOP20210131A1 (ar) 2023-01-30
FI3897833T3 (fi) 2026-04-07
KR102912203B1 (ko) 2026-01-16
MX2021007152A (es) 2021-11-03
TWI848031B (zh) 2024-07-11
DOP2021000116A (es) 2021-09-30
UY38514A (es) 2020-07-31
PE20212302A1 (es) 2021-12-10
CN113453760B (zh) 2024-05-24

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