JP7568641B2 - 治療的使用のためのキナーゼ阻害剤としての複素環式化合物 - Google Patents

治療的使用のためのキナーゼ阻害剤としての複素環式化合物 Download PDF

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JP7568641B2
JP7568641B2 JP2021560707A JP2021560707A JP7568641B2 JP 7568641 B2 JP7568641 B2 JP 7568641B2 JP 2021560707 A JP2021560707 A JP 2021560707A JP 2021560707 A JP2021560707 A JP 2021560707A JP 7568641 B2 JP7568641 B2 JP 7568641B2
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cancer
compound
inhibitors
disease
amino
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シェ，シン－パン
リー，クン－フン
リン，ウェン－シン
シー，チュアン
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ナショナル ヘルス リサーチ インスティトゥーツ
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2021560707A 2019-04-12 2020-04-09 治療的使用のためのキナーゼ阻害剤としての複素環式化合物 Active JP7568641B2 (ja)

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US201962833364P 2019-04-12 2019-04-12
US62/833,364 2019-04-12
PCT/US2020/027453 WO2020210481A1 (en) 2019-04-12 2020-04-09 Heterocyclic compounds as kinase inhibitors for therapeutic uses

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JP2022528780A5 JP2022528780A5 (https=) 2023-04-17
JP7568641B2 true JP7568641B2 (ja) 2024-10-16

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US (1) US20220213064A1 (https=)
EP (1) EP3952865A4 (https=)
JP (1) JP7568641B2 (https=)
KR (1) KR102913995B1 (https=)
CN (1) CN114025755B (https=)
AU (1) AU2020271855B2 (https=)
CA (1) CA3132855A1 (https=)
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Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12522583B2 (en) 2018-11-07 2026-01-13 Dana-Farber Cancer Institute, Inc. Benzimidazole derivatives and aza-benzimidazole derivatives as Janus kinase 2 inhibitors and uses thereof
EP3877371A4 (en) 2018-11-07 2022-07-27 Dana-Farber Cancer Institute, Inc. IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF
EP3876939A4 (en) 2018-11-07 2022-08-10 Dana-Farber Cancer Institute, Inc. Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof
US11691963B2 (en) 2020-05-06 2023-07-04 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
US12043632B2 (en) 2020-12-23 2024-07-23 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
WO2023086319A1 (en) 2021-11-09 2023-05-19 Ajax Therapeutics, Inc. 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
US12162881B2 (en) 2021-11-09 2024-12-10 Ajax Therapeutics, Inc. Forms and compositions of inhibitors of JAK2
CN114031561B (zh) * 2021-12-10 2022-12-02 江西科技师范大学 含4-苯氧基喹唑啉类化合物及其应用
KR102910577B1 (ko) * 2022-02-17 2026-01-08 내셔날 헬스 리서치 인스티튜트 융합 다환식 화합물의 제조 방법
CN116763787A (zh) * 2022-03-08 2023-09-19 安徽中科拓苒药物科学研究有限公司 喹啉类化合物的新用途
CN121219264A (zh) * 2023-05-12 2025-12-26 正大天晴药业集团股份有限公司 含有芳香双并环的化合物

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007516273A (ja) 2003-12-23 2007-06-21 ファイザー・インク 新規キノリン誘導体
JP2009534410A (ja) 2006-04-19 2009-09-24 ノバルティス アクチエンゲゼルシャフト ６−ｏ−置換ベンゾオキサゾールおよびベンゾチアゾール化合物ならびにｃｓｆ−１ｒシグナル伝達を阻害する方法
JP2010528009A (ja) 2007-05-21 2010-08-19 ノバルティス アーゲー Ｃｓｆ−１ｒ阻害剤、組成物および使用方法
US20100249182A1 (en) 2009-03-25 2010-09-30 Yoo Kyung-Ho Aminoquinoline derivatives, preparation method thereof and pharmaceutical composition comprising the same
JP2012511535A (ja) 2008-12-09 2012-05-24 ノバルティス アーゲー Ｖｅｇｆ−ｒ２のピリジルオキシインドール類阻害剤および疾患の処置のためのその使用
JP2012526054A (ja) 2009-05-05 2012-10-25 江▲蘇▼省▲薬▼物研究所有限公司 複素環置換のジフェニル尿素類誘導体及びその用途
CN104177346A (zh) 2013-05-21 2014-12-03 苏州科捷生物医药有限公司 喹唑啉类化合物及其用途
JP2018513150A (ja) 2015-04-07 2018-05-24 グアンドン・チョンシェン・ファーマスーティカル・カンパニー・リミテッド チロシンキナーゼ阻害剤およびそれを含む医薬組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1140840E (pt) * 1999-01-13 2006-05-31 Bayer Pharmaceuticals Corp Difenilureias substituidas com (.)-carboxiarilo como inibidores de raf-quinase
EP1158985B1 (en) * 1999-01-13 2011-12-28 Bayer HealthCare LLC OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
AU9598601A (en) * 2000-10-20 2002-04-29 Eisai Co Ltd Nitrogenous aromatic ring compounds
EP2210607B1 (en) * 2003-09-26 2011-08-17 Exelixis Inc. N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer
GB0509224D0 (en) * 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Inhibitors of intracellular enzymatic activity
CN101372475B (zh) * 2008-03-19 2012-01-04 南京工业大学 芳杂环取代的二苯脲类衍生物及其用途
US9358235B2 (en) * 2012-03-19 2016-06-07 Plexxikon Inc. Kinase modulation, and indications therefor
ES2913048T3 (es) * 2015-09-21 2022-05-31 Opna Immuno Oncology Sa Compuestos heterocíclicos y usos de estos
ES2904615T3 (es) * 2016-03-16 2022-04-05 Plexxikon Inc Compuestos y métodos para la modulación de quinasas e indicaciones al respecto

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007516273A (ja) 2003-12-23 2007-06-21 ファイザー・インク 新規キノリン誘導体
JP2009534410A (ja) 2006-04-19 2009-09-24 ノバルティス アクチエンゲゼルシャフト ６−ｏ−置換ベンゾオキサゾールおよびベンゾチアゾール化合物ならびにｃｓｆ−１ｒシグナル伝達を阻害する方法
JP2010528009A (ja) 2007-05-21 2010-08-19 ノバルティス アーゲー Ｃｓｆ−１ｒ阻害剤、組成物および使用方法
JP2012511535A (ja) 2008-12-09 2012-05-24 ノバルティス アーゲー Ｖｅｇｆ−ｒ２のピリジルオキシインドール類阻害剤および疾患の処置のためのその使用
US20100249182A1 (en) 2009-03-25 2010-09-30 Yoo Kyung-Ho Aminoquinoline derivatives, preparation method thereof and pharmaceutical composition comprising the same
JP2012526054A (ja) 2009-05-05 2012-10-25 江▲蘇▼省▲薬▼物研究所有限公司 複素環置換のジフェニル尿素類誘導体及びその用途
CN104177346A (zh) 2013-05-21 2014-12-03 苏州科捷生物医药有限公司 喹唑啉类化合物及其用途
JP2018513150A (ja) 2015-04-07 2018-05-24 グアンドン・チョンシェン・ファーマスーティカル・カンパニー・リミテッド チロシンキナーゼ阻害剤およびそれを含む医薬組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J． Med. Chem.，2013年，Vol.56，pp.5757-5772

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CN114025755B (zh) 2024-11-29
WO2020210481A8 (en) 2020-11-19
KR20210151818A (ko) 2021-12-14
CN114025755A (zh) 2022-02-08
CA3132855A1 (en) 2020-10-15
AU2020271855A1 (en) 2021-11-04
AU2020271855B2 (en) 2025-11-27
EP3952865A4 (en) 2023-05-03
KR102913995B1 (ko) 2026-01-16
WO2020210481A1 (en) 2020-10-15
EP3952865A1 (en) 2022-02-16
US20220213064A1 (en) 2022-07-07
TWI757722B (zh) 2022-03-11
JP2022528780A (ja) 2022-06-15
TW202104212A (zh) 2021-02-01

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