JP7548992B2 - タウタンパク質標的化化合物および関連する使用方法 - Google Patents

タウタンパク質標的化化合物および関連する使用方法 Download PDF

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JP7548992B2
JP7548992B2 JP2022502929A JP2022502929A JP7548992B2 JP 7548992 B2 JP7548992 B2 JP 7548992B2 JP 2022502929 A JP2022502929 A JP 2022502929A JP 2022502929 A JP2022502929 A JP 2022502929A JP 7548992 B2 JP7548992 B2 JP 7548992B2
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disease
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tau
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JP2022540935A5 (https=
JP2022540935A (ja
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クルー，アンドリュー・ピィ
バーリン，マイケル
ドン，ハンチン
イーシェンコ，アレクセイ
カカーチェ，アンジェラ・エム
チャンドラー，ジュリアン・ティ
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Arvinas Operations Inc
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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JP2022502929A 2019-07-17 2020-07-17 タウタンパク質標的化化合物および関連する使用方法 Active JP7548992B2 (ja)

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JP2024178191A (ja) * 2019-07-17 2024-12-24 アルビナス・オペレーションズ・インコーポレイテッド タウタンパク質標的化化合物および関連する使用方法

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CN115028679B (zh) * 2022-08-11 2022-11-15 深圳湾实验室 一种具有Cyclophilin A降解活性的PROTAC化合物及其制备方法与应用
WO2024097948A1 (en) 2022-11-04 2024-05-10 Roivant Discovery, Inc. Degraders of mdm2 and uses thereof
WO2024140638A1 (zh) * 2022-12-27 2024-07-04 标新生物医药科技(上海)有限公司 基于硫/氧取代戊二酰亚胺基异吲哚啉酮骨架的化合物及其应用
US12448399B2 (en) 2023-01-26 2025-10-21 Arvinas Operations, Inc. Cereblon-based KRAS degrading PROTACs and uses related thereto
US20240327381A1 (en) * 2023-02-08 2024-10-03 Celgene Corporation Compounds and Compositions for Selective Degradation of Engineered Proteins
CN116283512B (zh) * 2023-02-24 2025-04-25 博诺康源(北京)药业科技有限公司 一种合成维兰特罗及其盐的方法
WO2024182633A2 (en) * 2023-03-01 2024-09-06 The Regents Of The University Of California Targeted dephosphorylation of tau
EP4720071A1 (en) 2023-05-31 2026-04-08 Beone Medicines I GmbH Compounds for the degradation of egfr kinase
WO2025011624A1 (en) * 2023-07-11 2025-01-16 Etern Biopharma (Shanghai) Co., Ltd. Bifunctional compounds for androgen receptor degradation and methods of use
WO2025085387A1 (en) * 2023-10-16 2025-04-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Substituted-alkenyl-indazoles for imaging aggregated tau in tauopathies
CN119285633A (zh) * 2024-10-11 2025-01-10 中国药科大学 一种靶向降解Tau蛋白的疏水标签化合物及其制备和应用

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