JP7536424B2 - 多重特異性分子 - Google Patents
多重特異性分子 Download PDFInfo
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- JP7536424B2 JP7536424B2 JP2018563747A JP2018563747A JP7536424B2 JP 7536424 B2 JP7536424 B2 JP 7536424B2 JP 2018563747 A JP2018563747 A JP 2018563747A JP 2018563747 A JP2018563747 A JP 2018563747A JP 7536424 B2 JP7536424 B2 JP 7536424B2
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Classifications
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| JP2022078237A JP2022105574A (ja) | 2016-02-26 | 2022-05-11 | 多重特異性分子 |
| JP2023219531A JP2024026531A (ja) | 2016-02-26 | 2023-12-26 | 多重特異性分子 |
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| AU2016900708A AU2016900708A0 (en) | 2016-02-26 | Multi-specific molecules 1 | |
| AU2016900709 | 2016-02-26 | ||
| AU2016900708 | 2016-02-26 | ||
| AU2016900709A AU2016900709A0 (en) | 2016-02-26 | Multi-specific molecules 2 | |
| PCT/AU2017/050168 WO2017143406A1 (en) | 2016-02-26 | 2017-02-27 | Multi-specific molecules |
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| JP2022078237A Division JP2022105574A (ja) | 2016-02-26 | 2022-05-11 | 多重特異性分子 |
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| JP2019510812A5 JP2019510812A5 (enExample) | 2020-04-09 |
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| JP2023219531A Pending JP2024026531A (ja) | 2016-02-26 | 2023-12-26 | 多重特異性分子 |
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| JP2023219531A Pending JP2024026531A (ja) | 2016-02-26 | 2023-12-26 | 多重特異性分子 |
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| EP (1) | EP3419667A4 (enExample) |
| JP (3) | JP7536424B2 (enExample) |
| CN (1) | CN109310766A (enExample) |
| AU (2) | AU2017222700B2 (enExample) |
| TW (1) | TW201734037A (enExample) |
| WO (1) | WO2017143406A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017143406A1 (en) * | 2016-02-26 | 2017-08-31 | Imunexus Pty Ltd | Multi-specific molecules |
| WO2018014260A1 (en) | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
| WO2018068201A1 (en) | 2016-10-11 | 2018-04-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against ctla-4 |
| CN110944651A (zh) | 2017-02-08 | 2020-03-31 | 蜻蜓疗法股份有限公司 | 用于自然杀伤细胞激活的多特异性结合蛋白及其治疗癌症的治疗性用途 |
| ES2955074T3 (es) | 2017-02-20 | 2023-11-28 | Dragonfly Therapeutics Inc | Proteínas que se unen a HER2, NKG2D Y CD16 |
| MX2019013648A (es) | 2017-05-19 | 2021-01-08 | Wuxi Biologics Shanghai Co Ltd | Anticuerpos monoclonales novedosos para proteina 4 asociada con el linfocito t citotoxico (ctla-4). |
| EP3668893A4 (en) * | 2017-08-16 | 2021-08-04 | Dragonfly Therapeutics, Inc. | PROTEINS BINDING TO NKG2D, CD16 AND EGFR, HLA-E, CCR4, OR PD-L1 |
| CN117050184A (zh) | 2017-12-28 | 2023-11-14 | 南京传奇生物科技有限公司 | 针对tigit的单域抗体和其变体 |
| TW201930349A (zh) * | 2018-01-08 | 2019-08-01 | 大陸商南京傳奇生物科技有限公司 | 多重特異性抗原結合蛋白及其使用方法 |
| JP7366908B2 (ja) | 2018-01-15 | 2023-10-23 | ナンジン レジェンド バイオテック カンパニー,リミテッド | Pd-1に対する単一ドメイン抗体及びその変異体 |
| CA3090236A1 (en) | 2018-02-08 | 2019-08-15 | Dragonfly Therapeutics, Inc. | Combination therapy of cancer involving multi-specific binding proteins that activate natural killer cells |
| SG11202007482WA (en) | 2018-02-08 | 2020-09-29 | Dragonfly Therapeutics Inc | Antibody variable domains targeting the nkg2d receptor |
| KR102832460B1 (ko) | 2018-02-20 | 2025-07-11 | 드래곤플라이 쎄라퓨틱스, 인크. | Cd33, nkg2d, 및 cd16에 결합하는 다중-특이적 결합 단백질, 및 이의 사용 방법 |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| MA53293A (fr) | 2018-08-08 | 2021-11-17 | Dragonfly Therapeutics Inc | Protéines de liaison multi-spécifiques se liant à bcma, nkg2d et cd16, et méthodes d'utilisation |
| MX2021001527A (es) | 2018-08-08 | 2021-06-15 | Dragonfly Therapeutics Inc | Proteínas de unión a nkg2d, cd16 y a un antígeno asociado a tumor. |
| BR112021012631A2 (pt) | 2018-12-26 | 2021-12-14 | Xilio Dev Inc | Anticorpos anti-ctla4 e métodos de uso dos mesmos |
| KR20210131373A (ko) * | 2019-02-18 | 2021-11-02 | 커리어 테라퓨틱스, 인코포레이티드. | 오르토폭스바이러스 주요 조직적합성 복합체(mhc) 클래스 i-유사 단백질(omcp) 및 종양-특이 결합 파트너를 사용한 이중특이적 융합 단백질 |
| JP2022527761A (ja) * | 2019-03-26 | 2022-06-06 | フォーティ セブン, インコーポレイテッド | がん治療のための多重特異性作用物質 |
| EP3816185A1 (en) * | 2019-11-04 | 2021-05-05 | Numab Therapeutics AG | Multispecific antibody directed against pd-l1 and a tumor-associated antigen |
| EP4093745A4 (en) * | 2020-01-20 | 2024-03-06 | Wuxi Biologics Ireland Limited | NEW WASH BUFFER SOLUTION FOR AFFINITY CHROMATOGRAPHY |
| MX2022013944A (es) | 2020-05-06 | 2022-11-30 | Dragonfly Therapeutics Inc | Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a). |
| JP2023545135A (ja) * | 2020-10-12 | 2023-10-26 | グレフェックス, インコーポレイテッド | SARS-CoVタンパク質発現細胞に対するT細胞応答を標的にする抗体コンストラクト、それらの設計および使用 |
| WO2022187539A1 (en) | 2021-03-03 | 2022-09-09 | Dragonfly Therapeutics, Inc. | Methods of treating cancer using multi-specific binding proteins that bind nkg2d, cd16 and a tumor-associated antigen |
| US20250345423A1 (en) * | 2021-11-26 | 2025-11-13 | Imunexus Therapeutics Limited | Binding domain molecules on cell surfaces |
| CN115078718B (zh) * | 2022-07-22 | 2024-11-12 | 福建师范大学 | 一种基于表面增强拉曼技术检测透明质酸酶的方法 |
| EP4615859A2 (en) * | 2022-11-09 | 2025-09-17 | Repligen Corporation | Affinity agents |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002505103A (ja) | 1998-03-06 | 2002-02-19 | ダイアテック・ピーティワイ・リミテッド | V様ドメイン結合分子 |
| JP2010518062A (ja) | 2007-02-08 | 2010-05-27 | ドマンティス リミテッド | 血清アルブミンに対する抗体単一可変ドメイン |
| JP2011504742A (ja) | 2007-11-30 | 2011-02-17 | グラクソ グループ リミテッド | 抗原結合性構築物 |
| JP2012528112A (ja) | 2009-05-28 | 2012-11-12 | グラクソ グループ リミテッド | 抗原結合タンパク質 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1163339A1 (en) * | 1999-04-01 | 2001-12-19 | Innogenetics N.V. | A polypeptide structure for use as a scaffold |
| US20100081792A1 (en) * | 2001-06-28 | 2010-04-01 | Smithkline Beecham Corporation | Ligand |
| HRP20180045T1 (hr) * | 2008-10-02 | 2018-03-23 | Aptevo Research And Development Llc | Proteini antagonisti cd86 koji se vežu na više meta |
| CA2763493A1 (en) * | 2009-05-28 | 2010-12-02 | Glaxo Group Ltd. | Antigen-binding proteins |
| WO2017143406A1 (en) * | 2016-02-26 | 2017-08-31 | Imunexus Pty Ltd | Multi-specific molecules |
-
2017
- 2017-02-27 WO PCT/AU2017/050168 patent/WO2017143406A1/en not_active Ceased
- 2017-02-27 US US16/079,949 patent/US20190338013A1/en not_active Abandoned
- 2017-02-27 AU AU2017222700A patent/AU2017222700B2/en active Active
- 2017-02-27 EP EP17755659.4A patent/EP3419667A4/en active Pending
- 2017-02-27 CN CN201780024999.5A patent/CN109310766A/zh active Pending
- 2017-02-27 JP JP2018563747A patent/JP7536424B2/ja active Active
- 2017-03-01 TW TW106106646A patent/TW201734037A/zh unknown
-
2019
- 2019-01-02 AU AU2019200005A patent/AU2019200005A1/en not_active Abandoned
-
2020
- 2020-06-22 US US16/946,451 patent/US20210040177A1/en not_active Abandoned
-
2021
- 2021-04-06 US US17/223,935 patent/US11345736B2/en active Active
-
2022
- 2022-05-11 JP JP2022078237A patent/JP2022105574A/ja active Pending
-
2023
- 2023-08-28 US US18/239,052 patent/US20240182542A1/en active Pending
- 2023-12-26 JP JP2023219531A patent/JP2024026531A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002505103A (ja) | 1998-03-06 | 2002-02-19 | ダイアテック・ピーティワイ・リミテッド | V様ドメイン結合分子 |
| JP2010518062A (ja) | 2007-02-08 | 2010-05-27 | ドマンティス リミテッド | 血清アルブミンに対する抗体単一可変ドメイン |
| JP2011504742A (ja) | 2007-11-30 | 2011-02-17 | グラクソ グループ リミテッド | 抗原結合性構築物 |
| JP2012528112A (ja) | 2009-05-28 | 2012-11-12 | グラクソ グループ リミテッド | 抗原結合タンパク質 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022105574A (ja) | 2022-07-14 |
| CN109310766A (zh) | 2019-02-05 |
| US20240182542A1 (en) | 2024-06-06 |
| TW201734037A (zh) | 2017-10-01 |
| US20210230249A1 (en) | 2021-07-29 |
| US20210040177A1 (en) | 2021-02-11 |
| US20190338013A1 (en) | 2019-11-07 |
| AU2017222700B2 (en) | 2018-09-27 |
| EP3419667A1 (en) | 2019-01-02 |
| EP3419667A4 (en) | 2019-10-23 |
| AU2017222700A1 (en) | 2018-03-22 |
| WO2017143406A1 (en) | 2017-08-31 |
| AU2019200005A1 (en) | 2019-01-24 |
| JP2019510812A (ja) | 2019-04-18 |
| JP2024026531A (ja) | 2024-02-28 |
| US11345736B2 (en) | 2022-05-31 |
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