JP7519660B2 - 疾患を処置するための遺伝子改変された細胞、組織、および臓器 - Google Patents

疾患を処置するための遺伝子改変された細胞、組織、および臓器 Download PDF

Info

Publication number
JP7519660B2
JP7519660B2 JP2018565376A JP2018565376A JP7519660B2 JP 7519660 B2 JP7519660 B2 JP 7519660B2 JP 2018565376 A JP2018565376 A JP 2018565376A JP 2018565376 A JP2018565376 A JP 2018565376A JP 7519660 B2 JP7519660 B2 JP 7519660B2
Authority
JP
Japan
Prior art keywords
cells
genetically modified
hla
human
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018565376A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019517803A (ja
JP2019517803A5 (https=
Inventor
バーナード ジェイ． へリング，
クリストファー ブルラク，
Original Assignee
リージェンツ オブ ザ ユニバーシティ オブ ミネソタ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by リージェンツ オブ ザ ユニバーシティ オブ ミネソタ filed Critical リージェンツ オブ ザ ユニバーシティ オブ ミネソタ
Publication of JP2019517803A publication Critical patent/JP2019517803A/ja
Publication of JP2019517803A5 publication Critical patent/JP2019517803A5/ja
Priority to JP2021212142A priority Critical patent/JP2022031487A/ja
Priority to JP2022129299A priority patent/JP2022160703A/ja
Application granted granted Critical
Publication of JP7519660B2 publication Critical patent/JP7519660B2/ja
Priority to JP2024154774A priority patent/JP2024178220A/ja
Priority to JP2025015908A priority patent/JP2025076449A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/106—Primate
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2018565376A 2016-06-14 2017-06-14 疾患を処置するための遺伝子改変された細胞、組織、および臓器 Active JP7519660B2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2021212142A JP2022031487A (ja) 2016-06-14 2021-12-27 疾患を処置するための遺伝子改変された細胞、組織、および臓器
JP2022129299A JP2022160703A (ja) 2016-06-14 2022-08-15 疾患を処置するための遺伝子改変された細胞、組織、および臓器
JP2024154774A JP2024178220A (ja) 2016-06-14 2024-09-09 疾患を処置するための遺伝子改変された細胞、組織、および臓器
JP2025015908A JP2025076449A (ja) 2016-06-14 2025-02-03 疾患を処置するための遺伝子改変された細胞、組織、および臓器

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662350048P 2016-06-14 2016-06-14
US62/350,048 2016-06-14
PCT/US2017/037566 WO2017218714A1 (en) 2016-06-14 2017-06-14 Genetically modified cells, tissues, and organs for treating disease

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2021212142A Division JP2022031487A (ja) 2016-06-14 2021-12-27 疾患を処置するための遺伝子改変された細胞、組織、および臓器
JP2022129299A Division JP2022160703A (ja) 2016-06-14 2022-08-15 疾患を処置するための遺伝子改変された細胞、組織、および臓器

Publications (3)

Publication Number Publication Date
JP2019517803A JP2019517803A (ja) 2019-06-27
JP2019517803A5 JP2019517803A5 (https=) 2020-07-27
JP7519660B2 true JP7519660B2 (ja) 2024-07-22

Family

ID=60663278

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2018565376A Active JP7519660B2 (ja) 2016-06-14 2017-06-14 疾患を処置するための遺伝子改変された細胞、組織、および臓器
JP2021212142A Pending JP2022031487A (ja) 2016-06-14 2021-12-27 疾患を処置するための遺伝子改変された細胞、組織、および臓器
JP2022129299A Pending JP2022160703A (ja) 2016-06-14 2022-08-15 疾患を処置するための遺伝子改変された細胞、組織、および臓器
JP2024154774A Pending JP2024178220A (ja) 2016-06-14 2024-09-09 疾患を処置するための遺伝子改変された細胞、組織、および臓器
JP2025015908A Pending JP2025076449A (ja) 2016-06-14 2025-02-03 疾患を処置するための遺伝子改変された細胞、組織、および臓器

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2021212142A Pending JP2022031487A (ja) 2016-06-14 2021-12-27 疾患を処置するための遺伝子改変された細胞、組織、および臓器
JP2022129299A Pending JP2022160703A (ja) 2016-06-14 2022-08-15 疾患を処置するための遺伝子改変された細胞、組織、および臓器
JP2024154774A Pending JP2024178220A (ja) 2016-06-14 2024-09-09 疾患を処置するための遺伝子改変された細胞、組織、および臓器
JP2025015908A Pending JP2025076449A (ja) 2016-06-14 2025-02-03 疾患を処置するための遺伝子改変された細胞、組織、および臓器

Country Status (8)

Country Link
US (1) US20190335726A1 (https=)
EP (1) EP3468356A4 (https=)
JP (5) JP7519660B2 (https=)
KR (2) KR20230110373A (https=)
CN (2) CN109640645B (https=)
AU (1) AU2017285224B2 (https=)
CA (1) CA3027428A1 (https=)
WO (1) WO2017218714A1 (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US9950282B2 (en) 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
US10967298B2 (en) 2012-03-15 2021-04-06 Flodesign Sonics, Inc. Driver and control for variable impedence load
SG11201602232UA (en) 2013-09-24 2016-04-28 Giner Inc System for gas treatment of a cell implant
WO2015105955A1 (en) 2014-01-08 2015-07-16 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
CN116059378A (zh) 2014-12-10 2023-05-05 明尼苏达大学董事会 用于治疗疾病的遗传修饰的细胞、组织和器官
US11021699B2 (en) 2015-04-29 2021-06-01 FioDesign Sonics, Inc. Separation using angled acoustic waves
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
WO2018075830A1 (en) 2016-10-19 2018-04-26 Flodesign Sonics, Inc. Affinity cell extraction by acoustics
AU2017361260B2 (en) 2016-11-15 2023-06-08 Giner, Inc. Percutaneous gas diffusion device suitable for use with a subcutaneous implant
CN110831656A (zh) 2017-05-04 2020-02-21 吉纳生命科学公司 稳健的可植入气体递送装置和方法、系统以及包括该装置的装置
KR102439221B1 (ko) 2017-12-14 2022-09-01 프로디자인 소닉스, 인크. 음향 트랜스듀서 구동기 및 제어기
EP3866815B1 (en) * 2018-10-19 2024-05-01 Regents Of The University Of Minnesota Transplant tolerance induction with carbodiimide treated tolerizing vaccine
EP3760718A1 (en) * 2019-07-04 2021-01-06 Medizinische Hochschule Hannover Tissue for use as allogeneic or xenogeneic transplant and method for its production
CN111264469B (zh) * 2020-02-27 2022-03-25 西安交通大学医学院第一附属医院 一种基因免疫诱导的甲状腺相关性眼病动物模型的构建方法及雷帕霉素类药物的应用
US20230123863A1 (en) * 2020-06-30 2023-04-20 National Yang-Ming University A glia cell and neuron co-culture system and method
CN111500693B (zh) * 2020-07-02 2020-09-22 中南大学 检测巨噬细胞中rfx1表达水平的试剂在制备巨噬细胞分型检测制剂中的应用
WO2023015307A1 (en) * 2021-08-06 2023-02-09 Rutgers, The State University Of New Jersey Method for producing genetically modified cells
US20240358761A1 (en) * 2021-08-11 2024-10-31 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy
CN114958768B (zh) * 2022-06-02 2023-03-24 健颐生物科技发展(山东)有限公司 Fgf10旁分泌通用型人成纤维细胞制剂的制备方法
WO2026039661A1 (en) * 2024-08-15 2026-02-19 Regeneron Pharmaceuticals, Inc. Non-human animals with humanized fc epsilon receptors that lack functional alpha-1, 3-galactosyltransferase (ggta1)

Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770201A (en) 1994-12-23 1998-06-23 Rijsuniversiteit Te Leiden HA-2 antigenic peptide
JP2000510709A (ja) 1997-02-21 2000-08-22 コミサリア ア レネルジィエ アトミック 少なくとも１種のｈｌａ―ｇイソ型をその表面で発現する真核細胞、およびその使用
US6156306A (en) 1994-08-17 2000-12-05 Albert Einstein College Of Medicine Of Yeshiva University Pancreatic β-cells for allogeneic transplantation without immunosuppression
JP2001518066A (ja) 1996-03-20 2001-10-09 ブリストル―マイヤーズ スクイッブ カンパニー Ｇｐ３９／ｃｄ４０およびｃｔｌａ４／ｃｄ２８／ｂ７経路のブロックによって免疫反応を阻止する方法およびそれに使用する組成物
JP2003509031A (ja) 1999-09-13 2003-03-11 ユニバシティ オブ マサチューセッツ、ア パブリック インスチチユーション オブ ハイアー エデュケイション オブ ザ コモンウエルス オブ マサチューセッツ、アズ リプリゼンテッド バイ イッツ アマースト キャンパス ドナー細胞又は分化細胞からの核を使用する豚のクローニング並びに多能性豚の産生
US20050123525A1 (en) 2003-11-13 2005-06-09 Ulrich Martin Composition and method for inducing immune tolerance towards cell, tissue and/or organ transplants
WO2011019385A1 (en) 2009-08-11 2011-02-17 Sangamo Biosciences, Inc. Organisms homozygous for targeted modification
JP2012502074A (ja) 2008-09-30 2012-01-26 キュアバック ゲーエムベーハー 哺乳動物において免疫を賦活する応答を提供または増強するための複合化された（ｍ）ＲＮＡと裸のｍＲＮＡとを含んでいる組成物、およびその使用
JP2012507995A (ja) 2008-11-07 2012-04-05 エイチエルエイ−ジー・テクノロジーズ Ｈｌａ−ｇポリペプチドおよびその医薬的使用
JP2012507994A (ja) 2008-11-07 2012-04-05 エイチエルエイ−ジー・テクノロジーズ Ｈｌａ−ｇタンパク質及びその薬学的使用
JP2013501528A (ja) 2009-08-14 2013-01-17 レビビコア， インコーポレイテッド 糖尿病の処置のためのマルチ・トランスジェニック・ブタ
CN102911270A (zh) 2011-08-05 2013-02-06 浙江大学 一种抑制移植器官慢性排斥反应的抗体的制备及纯化方法
US20130177577A1 (en) 2010-07-12 2013-07-11 Dana-Farber Cancer Institute, Inc. Nlrc5 as a target to intervene mhc class 1-mediated immune responses
JP2013545469A (ja) 2010-12-03 2013-12-26 ビオエンテッヒ・アクチェンゲゼルシャフト 細胞ｒｎａ発現のための方法
JP2014509195A (ja) 2011-02-25 2014-04-17 リコンビネティクス・インコーポレイテッド 遺伝子改変動物、およびそれを作製する方法
JP2015529457A (ja) 2012-07-31 2015-10-08 バジル・エム・ハンタッシュＢａｓｉｌ Ｍ． ＨＡＮＴＡＳＨ Ｈｌａｇ改変された細胞および方法
JP2016514462A (ja) 2013-03-16 2016-05-23 ノバルティス アーゲー ヒト化抗ｃｄ１９キメラ抗原受容体を使用するがんの処置

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11510698A (ja) * 1995-08-04 1999-09-21 ザ ジェネラル ホスピタル コーポレイション トランスジェニックブタ及びヒトｈｌａ遺伝子を有するブタ細胞
WO2002064748A2 (en) * 2001-02-14 2002-08-22 Furcht Leo T Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
KR100417566B1 (ko) * 1999-11-19 2004-02-05 한국생명공학연구원 체세포 핵치환 복제수정란의 대량생산방법
AU2001297523B2 (en) * 2000-11-17 2007-01-18 Sab, Llc Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates
AU2002357110A1 (en) * 2001-12-07 2003-07-09 The Ohio State University Research Foundation Apoptotic ebv-transformed lymphocytes, a therapeutic agent for post-transplant lymphoproliferative disorder
KR20090068646A (ko) * 2007-12-24 2009-06-29 (주)엠젠 Ｈｌａ-ｇ 유전자 및 ｄａｆ 유전자를 발현하는 형질전환복제 돼지 및 그의 제조 방법
KR20100022684A (ko) * 2008-08-20 2010-03-03 (주)엠젠 세 개의 유전자를 발현하는 복합형질전환 복제 돼지 및 그의 제조 방법
CN102300578A (zh) * 2008-12-01 2011-12-28 延寿有限责任公司 用于改变健康、安康和寿命的方法和组合物
US8734786B2 (en) * 2009-09-16 2014-05-27 Northwestern University Use of ECDI-fixed cell tolerance as a method for preventing allograft rejection
WO2012031008A2 (en) * 2010-08-31 2012-03-08 The General Hospital Corporation Cancer-related biological materials in microvesicles
ES2680636T3 (es) * 2011-02-14 2018-09-10 Revivicor Inc. Cerdos genéticamente modificados para xenotrasplante de xenoinjertos vascularizados y derivados de los mismos
DK2830662T3 (da) * 2012-03-29 2019-01-02 Univ Columbia Fremgangsmåder til behandlng af hårtabsforstyrrelser
WO2013188358A1 (en) * 2012-06-12 2013-12-19 The General Hospital Corporation Miniature swine transgenic for one or more coagulation factors
US20140115728A1 (en) * 2012-10-24 2014-04-24 A. Joseph Tector Double knockout (gt/cmah-ko) pigs, organs and tissues
CN104046593A (zh) * 2013-03-14 2014-09-17 浙江大学 一种低免疫原性的人细胞及其制备方法
JP2016538001A (ja) * 2013-11-28 2016-12-08 ホライズン・ジェノミクス・ゲーエムベーハー 体細胞半数体ヒト細胞株
WO2015184259A1 (en) * 2014-05-30 2015-12-03 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods to treat latent viral infections
SI3161128T1 (sl) * 2014-06-26 2019-02-28 Regeneron Pharmaceuticals, Inc. Postopki in sestavki za ciljano genetsko spremembo in postopki uporabe
CN105586389A (zh) * 2014-10-21 2016-05-18 天津华大基因科技有限公司 试剂盒及其在检测遗传性骨病基因中的用途
CA2965550A1 (en) * 2014-10-22 2016-04-28 Indiana University Research & Technology Corporation Triple transgenic pigs suitable for xenograft
CN116059378A (zh) * 2014-12-10 2023-05-05 明尼苏达大学董事会 用于治疗疾病的遗传修饰的细胞、组织和器官
CN104789592A (zh) * 2015-03-19 2015-07-22 中国食品药品检定研究院 一种制备α-1,3GT基因敲除的非人哺乳动物的方法及应用

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6156306A (en) 1994-08-17 2000-12-05 Albert Einstein College Of Medicine Of Yeshiva University Pancreatic β-cells for allogeneic transplantation without immunosuppression
US5770201A (en) 1994-12-23 1998-06-23 Rijsuniversiteit Te Leiden HA-2 antigenic peptide
JP2001518066A (ja) 1996-03-20 2001-10-09 ブリストル―マイヤーズ スクイッブ カンパニー Ｇｐ３９／ｃｄ４０およびｃｔｌａ４／ｃｄ２８／ｂ７経路のブロックによって免疫反応を阻止する方法およびそれに使用する組成物
JP2000510709A (ja) 1997-02-21 2000-08-22 コミサリア ア レネルジィエ アトミック 少なくとも１種のｈｌａ―ｇイソ型をその表面で発現する真核細胞、およびその使用
JP2003509031A (ja) 1999-09-13 2003-03-11 ユニバシティ オブ マサチューセッツ、ア パブリック インスチチユーション オブ ハイアー エデュケイション オブ ザ コモンウエルス オブ マサチューセッツ、アズ リプリゼンテッド バイ イッツ アマースト キャンパス ドナー細胞又は分化細胞からの核を使用する豚のクローニング並びに多能性豚の産生
US20050123525A1 (en) 2003-11-13 2005-06-09 Ulrich Martin Composition and method for inducing immune tolerance towards cell, tissue and/or organ transplants
JP2012502074A (ja) 2008-09-30 2012-01-26 キュアバック ゲーエムベーハー 哺乳動物において免疫を賦活する応答を提供または増強するための複合化された（ｍ）ＲＮＡと裸のｍＲＮＡとを含んでいる組成物、およびその使用
JP2012507995A (ja) 2008-11-07 2012-04-05 エイチエルエイ−ジー・テクノロジーズ Ｈｌａ−ｇポリペプチドおよびその医薬的使用
JP2012507994A (ja) 2008-11-07 2012-04-05 エイチエルエイ−ジー・テクノロジーズ Ｈｌａ−ｇタンパク質及びその薬学的使用
WO2011019385A1 (en) 2009-08-11 2011-02-17 Sangamo Biosciences, Inc. Organisms homozygous for targeted modification
JP2013501528A (ja) 2009-08-14 2013-01-17 レビビコア， インコーポレイテッド 糖尿病の処置のためのマルチ・トランスジェニック・ブタ
US20130177577A1 (en) 2010-07-12 2013-07-11 Dana-Farber Cancer Institute, Inc. Nlrc5 as a target to intervene mhc class 1-mediated immune responses
JP2013545469A (ja) 2010-12-03 2013-12-26 ビオエンテッヒ・アクチェンゲゼルシャフト 細胞ｒｎａ発現のための方法
JP2014509195A (ja) 2011-02-25 2014-04-17 リコンビネティクス・インコーポレイテッド 遺伝子改変動物、およびそれを作製する方法
CN102911270A (zh) 2011-08-05 2013-02-06 浙江大学 一种抑制移植器官慢性排斥反应的抗体的制备及纯化方法
JP2015529457A (ja) 2012-07-31 2015-10-08 バジル・エム・ハンタッシュＢａｓｉｌ Ｍ． ＨＡＮＴＡＳＨ Ｈｌａｇ改変された細胞および方法
JP2016514462A (ja) 2013-03-16 2016-05-23 ノバルティス アーゲー ヒト化抗ｃｄ１９キメラ抗原受容体を使用するがんの処置

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
Ａｍ．Ｊ．Ｔｒａｎｓｐｌａｎｔ．，２０１４，Ｖｏｌ．１４，ｐｐ．２７１３－２７２２
Ｊ．Ｅｘｐ．Ｍｅｄ．，２００１，Ｖｏｌ．１９３，Ｎｏ．８，ｐｐ．９７５－９８０
Ｊ．Ｉｍｍｕｎｏｌ．，２００１，Ｖｏｌ．１６７，ｐｐ．６００２－６００８
Ｎａｔ．Ｂｉｏｔｅｃｈｎｏｌ．，２０１３，Ｖｏｌ．３１，Ｎｏ．３，ｐｐ．２２７－２２９
Ｒｅｇｅｎ．Ｍｅｄ．，２０１４，Ｖｏｌ．９，Ｎｏ．６，ｐｐ．７７５－７８４
Ｓｔｅｍ Ｃｅｌｌ Ｒｅｓ．，２０１４，Ｖｏｌ．１３，ｐｐ．３４２－３５４
Ｔｒａｎｓｐｌａｎｔ Ｉｍｍｕｎｏｌ．，２００３，Ｖｏｌ．１１，ｐｐ．１４７－１５３
Ｔｒａｎｓｐｌａｎｔ Ｉｍｍｕｎｏｌ．，２０１５，Ｖｏｌ．３２，ｐｐ．１０９－１１５
Ｘｅｎｏｔｒａｎｓｐｌａｎｔａｔｉｏｎ，１９９９，Ｖｏｌ．６，ｐｐ．５２－６５
Ｘｅｎｏｔｒａｎｓｐｌａｎｔａｔｉｏｎ，２０１３，Ｖｏｌ．２０，ｐ．６４

Also Published As

Publication number Publication date
CN109640645B (zh) 2021-10-15
JP2019517803A (ja) 2019-06-27
AU2017285224B2 (en) 2023-05-18
CN114176043B (zh) 2024-04-23
KR20230110373A (ko) 2023-07-21
JP2022031487A (ja) 2022-02-18
JP2022160703A (ja) 2022-10-19
EP3468356A4 (en) 2020-02-26
JP2024178220A (ja) 2024-12-24
KR20190017985A (ko) 2019-02-20
EP3468356A1 (en) 2019-04-17
AU2017285224A1 (en) 2019-01-17
CN114176043A (zh) 2022-03-15
CA3027428A1 (en) 2017-12-21
WO2017218714A1 (en) 2017-12-21
US20190335726A1 (en) 2019-11-07
CN109640645A (zh) 2019-04-16
JP2025076449A (ja) 2025-05-15

Similar Documents

Publication Publication Date Title
JP7519660B2 (ja) 疾患を処置するための遺伝子改変された細胞、組織、および臓器
US12465029B2 (en) Genetically modified cells, tissues, and organs for treating disease
Cooper et al. Generation of gene edited birds in one generation using sperm transfection assisted gene editing (STAGE)
EP1437404A1 (en) Tailor-made multifunctional stem cells and utilization thereof
KR20180091821A (ko) 유전적 상보성에 의한 인간화 car t-세포 및 혈소판의 조작방법
JP2019502400A (ja) キメラ胚補助臓器作製用の組成物及び方法
JP2022043344A (ja) 多能性細胞に関連する方法
US20220061279A1 (en) Genetically modified cells, tissues, and organs for treating disease
JP2018522553A (ja) ヒト化骨格筋

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200615

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20200615

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210726

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20211026

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20211227

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20220413

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220815

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20220815

C11 Written invitation by the commissioner to file amendments

Free format text: JAPANESE INTERMEDIATE CODE: C11

Effective date: 20220823

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20220912

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20220913

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20221104

C211 Notice of termination of reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C211

Effective date: 20221108

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240315

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20240702

R150 Certificate of patent or registration of utility model

Ref document number: 7519660

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150